Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections

Levels of the soluble form of the triggering receptor expressed on myeloid cells (sTREM)-1 are elevated in severe sepsis. However, it is not known whether sTREM-1 measurements can distinguish milder bacterial infections from noninfectious inflammation. The present authors studied whether serum sTREM...

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Bibliographic Details
Published in:	The European respiratory journal Vol. 28; no. 4; pp. 695 - 702
Main Authors:	Phua, J, Koay, E. S. C, Zhang, D, Tai, L. K, Boo, X. L, Lim, K. C, Lim, T. K
Format:	Journal Article
Language:	English
Published:	Leeds Eur Respiratory Soc 01-10-2006 Maney
Subjects:	Adult Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Asthma - blood Biological and medical sciences Biomarkers - blood Chronic obstructive pulmonary disease, asthma Female Humans Male Medical sciences Membrane Glycoproteins - blood Middle Aged Pneumology Pneumonia, Bacterial - blood Pneumonia, Bacterial - drug therapy Pulmonary Disease, Chronic Obstructive - blood Receptors, Immunologic - blood Triggering Receptor Expressed on Myeloid Cells-1 Lung disease Pneumonia Respiratory disease Chronic disease Acute Myeloid cell respiratory infections Asthma Infection Respiratory tract Antibiotic Antibiotics soluble form of the triggering receptor expressed on myeloid cells-1 Bronchus disease Obstructive pulmonary disease Triggering Biological receptor chronic obstructive pulmonary disease
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Summary:	Levels of the soluble form of the triggering receptor expressed on myeloid cells (sTREM)-1 are elevated in severe sepsis. However, it is not known whether sTREM-1 measurements can distinguish milder bacterial infections from noninfectious inflammation. The present authors studied whether serum sTREM-1 levels differ in community-acquired pneumonia, exacerbations of chronic obstructive pulmonary disease (COPD), asthma and controls, and whether sTREM-1 may be used as a surrogate marker for the need for antibiotics. Serum sTREM-1 levels in 150 patients with pneumonia, COPD and asthma exacerbations and 62 healthy controls were measured. Serum sTREM-1 levels were significantly elevated in pneumonia (median 295.2 ng x mL(-1)), COPD (280.3 ng x mL(-1)) and asthma exacerbations (184.0 ng x mL(-1)) compared with controls (83.1 ng x mL(-1)). Levels were higher in pneumonia and Anthonisen type 1 COPD exacerbations than in type 2 and 3 COPD and asthma exacerbations. The area under the receiver operating characteristics curve for sTREM-1 as a surrogate marker for the need for antibiotics was 0.77. Serum levels of the soluble form of the triggering receptor expressed on myeloid cells-1 were elevated predominantly in pneumonia and Anthonisen type 1 COPD exacerbations versus type 2 and 3 chronic obstructive pulmonary disease exacerbations, asthma and controls. Serum levels of the soluble form of the triggering receptor expressed on myeloid cells-1 has moderate but insufficient accuracy as a surrogate marker for the need for antibiotics in lower respiratory tract infections.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0903-1936 1399-3003
DOI:	10.1183/09031936.06.00005606