Photonic Crystal Fiber Surface Plasmon Resonance Biosensor Based on Protein G Immobilization

A gold-coated photonic crystal optical fiber (PCF) sensor has been proposed as a surface plasmon resonance biosensor. The sensor was fabricated by collapsing the holes of PCF at both ends, causing the light from the multimode fiber to reach the cladding/gold interface for surface plasmon excitation....

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Bibliographic Details
Published in:	IEEE journal of selected topics in quantum electronics Vol. 19; no. 3; p. 4602107
Main Authors:	Wong, Wei Chang, Chan, Chi Chiu, Boo, Jia Liang, Teo, Zi Yong, Tou, Zhi Qiang, Yang, Hong Bin, Li, Chang Ming, Leong, Kam Chew
Format:	Journal Article
Language:	English
Published:	New York IEEE 01-05-2013 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Biosensor Biosensors Crystal fibers Gold Monitors optical fiber sensor Optical fiber sensors Optical fibers photonic crystal fiber (PCF) Photonic crystals Plasmons protein G Proteins Refractive index Sensitivity Sensors surface plasmon resonance (SPR) Surface treatment
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Summary:	A gold-coated photonic crystal optical fiber (PCF) sensor has been proposed as a surface plasmon resonance biosensor. The sensor was fabricated by collapsing the holes of PCF at both ends, causing the light from the multimode fiber to reach the cladding/gold interface for surface plasmon excitation. Mixed thiol and protein G coating were employed on the gold surface, which improved the orientation of the IgG leading to enhanced performance. The sensor was able to monitor the binding kinetics of the IgG (anti-IgG) complexes and a minimum detection limit at a concentration of 0.267 mg/L of anti-IgG was found.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1077-260X 1558-4542
DOI:	10.1109/JSTQE.2013.2244560