Search Results - "Bonyhadi, Mark"

Potency assay development for cellular therapy products: an ISCT review of the requirements and experiences in the industry by Bravery, Christopher A, Carmen, Jessica, Fong, Timothy, Oprea, Wanda, Hoogendoorn, Karin H, Woda, Juliana, Burger, Scott R, Rowley, Jon A, Bonyhadi, Mark L, Van't Hof, Wouter

“…Abstract The evaluation of potency plays a key role in defining the quality of cellular therapy products (CTPs). Potency can be defined as a quantitative…”
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Suppression of Disease in New Zealand Black/New Zealand White Lupus-Prone Mice by Adoptive Transfer of Ex Vivo Expanded Regulatory T Cells by Scalapino, Kenneth J, Tang, Qizhi, Bluestone, Jeffrey A, Bonyhadi, Mark L, Daikh, David I

“…An increasing number of studies indicate that a subset of CD4(+) T cells with regulatory capacity (regulatory T cells; T(regs)) can function to control…”
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Current perspectives on the use of ancillary materials for the manufacture of cellular therapies by Solomon, Jennifer, Csontos, Lynn, Clarke, Dominic, Bonyhadi, Mark, Zylberberg, Claudia, McNiece, Ian, Kurtzberg, Joanne, Bell, Rosemarie, Deans, Robert

“…Abstract Continued growth in the cell therapy industry and commercialization of cell therapies that successfully advance through clinical trials has led to…”
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HIV induces thymus depletion in vivo by Bonyhadi, Mark L, Rabin, Linda, Salimi, Suzan, Brown, Daniel A, Kosek, Jon, McCune, Joseph M, Kaneshima, Hideto

“…Human immunodeficiency virus (HIV) disease is typified by declining CD4+ T lymphocyte counts in the peripheral circulation, a loss which may be secondary to…”
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Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID β2mnull mice by Nervi, Bruno, Rettig, Michael P, Ritchey, Julie K, Wang, Hanlin L, Bauer, Gerhard, Walker, Jon, Bonyhadi, Mark L, Berenson, Ronald J, Prior, Julie L, Piwnica-Worms, David, Nolta, Jan A, DiPersio, John F

“…Objective Graft-vs-host disease (GVHD) is the major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Models of…”
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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes by Tang, Qizhi, Henriksen, Kammi J, Bi, Mingying, Finger, Erik B, Szot, Greg, Ye, Jianqin, Masteller, Emma L, McDevitt, Hugh, Bonyhadi, Mark, Bluestone, Jeffrey A

“…The low number of CD4+ CD25+ regulatory T cells (Tregs), their anergic phenotype, and diverse antigen specificity present major challenges to harnessing this…”
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Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors by NOONAN, Kimberly, MATSUI, William, SERAFINI, Paolo, CARBLEY, Rebecca, TAN, Gladys, KHALILI, Jahan, BONYHADI, Mark, LEVITSKY, Hyam, WHARTENBY, Katie, BORRELLO, Ivan

“…A major limitation of adoptive immunotherapy is the availability of T cells specific for both terminally differentiated tumor cells and their clonogenic…”
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Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes by Bondanza, Attilio, Valtolina, Veronica, Magnani, Zulma, Ponzoni, Maurilio, Fleischhauer, Katharina, Bonyhadi, Mark, Traversari, Catia, Sanvito, Francesca, Toma, Salvatore, Radrizzani, Marina, La Seta-Catamancio, Simona, Ciceri, Fabio, Bordignon, Claudio, Bonini, Chiara

“…In allogeneic hematopoietic cell transplantation (allo-HCT), the immune recognition of host antigens by donor T lymphocytes leads to a beneficial…”
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Cell isolation and expansion using Dynabeads by Neurauter, Axl A, Bonyhadi, Mark, Lien, Eli, Nøkleby, Lars, Ruud, Erik, Camacho, Stephanie, Aarvak, Tanja

“…This chapter describes the use of Dynabeads for cell isolation and expansion. Dynabeads are uniform polystyrene spherical beads that have been made…”
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Optimization of human T-cell expansion ex vivo using magnetic beads conjugated with anti-CD3 and anti-CD28 antibodies by KALAMASZ, Dale, LONG, S. A, TANIGUCHI, Ruth, BUCKNER, Jane H, BERENSON, Ronald J, BONYHADI, Mark

“…T-cell receptor engagement and accompanying costimulatory signals control the level of activation and functional potential of individual T cells. The authors…”
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Standardized analysis for the quantification of Vβ CDR3 T-cell receptor diversity by Long, S. Alice, Khalili, Jahan, Ashe, Jimiane, Berenson, Ron, Ferrand, Christophe, Bonyhadi, Mark

“…Assessment of the diversity of the T-cell receptor (TCR) repertoire is often determined by measuring the frequency and distribution of individually rearranged…”
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Highly efficient expansion of human CD4+CD25+ regulatory T cells for cellular immunotherapy in patients with graft-versus-host disease by KARAKHANOVA, Svetlana, MUNDER, Markus, SCHNEIDER, Markus, BONYHADI, Mark, HO, Anthony D, GOERNER, Martin

“…CD4+CD25+ regulatory T cells (T(REG)) are engaged in the regulation of murine and human immune responses as well as graft-versus-host disease (GvHD) after…”
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Combined Cytoreduction and Infusion of Anti-CD3/Anti-CD28 Bead-Activated T Cells Prevent Diabetes in NOD Mice by Berenson, Ronald J., Long, Sarah A., Bonyhadi, Mark L.

“…Autoreactive T cells are found in many autoimmune diseases (AID). Most current therapies rely on chronic immunosuppression, which increases the risks of…”
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CD4+CD25+ Marrow Infiltrating Lymphocytes in Myeloma Patients Display an Activated Phenotype and Lack Suppressive Function by Noonan, Kimberly A., Mgebroff, Stephanie, Serafini, Paolo, Meckel, Kristen, Bonyhadi, Mark, Borrello, Ivan

“…We have previously shown that marrow infiltrating lymphocytes (MILs) from myeloma patients proliferate upon stimulation with anti-CD3/CD28 beads more…”
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In Vitro Engagement of CD3 and CD28 Corrects T Cell Defects in Chronic Lymphocytic Leukemia by Bonyhadi, Mark, Frohlich, Mark, Rasmussen, Angela, Ferrand, Christophe, Grosmaire, Laura, Robinet, Eric, Leis, Jose, Maziarz, Richard T, Tiberghien, Pierre, Berenson, Ronald J

“…Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of leukemic B cells concomitant with immunological abnormalities and depressed immune…”
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Regulatory T-cell expansion and function do not account for the impaired alloreactivity of ex vivo-expanded T cells by Montcuquet, Nicolas, Mercier-Letondal, Patricia, Perruche, Sylvain, Duperrier, Anne, Couturier, Mélanie, Bouchekioua, Abdelghani, Bonyhadi, Mark, Ferrand, Christophe, Tiberghien, Pierre, Robinet, Eric

“…CD3- and CD28-activated T cells expanded for 12 days ex vivo to produce suicide gene-modified T cells are hyporesponsive to alloantigens. To investigate…”
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Xcellerated T Cells™: Phase I/II Studies of Xcellerated T Cells for Treating Hematological Malignancies by Bonyhadi, Mark, Berenson, Ronald, Frohlich, Mark

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Standardized analysis for the quantification of Vbeta CDR3 T-cell receptor diversity by Long, S Alice, Khalili, Jahan, Ashe, Jimiane, Berenson, Ron, Ferrand, Christophe, Bonyhadi, Mark

“…Assessment of the diversity of the T-cell receptor (TCR) repertoire is often determined by measuring the frequency and distribution of individually rearranged…”
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Anti-CD3/Anti-CD28 Bead-Activated T Cells Facilitate Engraftment of Murine Histoincompatible Allogeneic Transplants after Low-Dose Radiation by Berenson, Ronald J., Ritchey, Julie K., Bonyhadi, Mark L., DiPersio, John F.

“…Donor T cells are known to facilitate hematolymphoid engraftment following allogeneic stem cell transplantation. The recent development of the Xcellerate…”
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Comparison of the Proliferative Kinetics, GVHD Potential and GCV Sensitivity of Naive and Transduced and Selected Murine T Cells after Allogeneic BMT by Rettig, Michael, Ritchey, Julie, Prior, Julie, Piwnica-Worms, David, Bonyhadi, Mark, DiPersio, John

“…We and others have previously demonstrated that early administration of the prodrug ganciclovir (GCV) protects mice from lethal GVHD after BMT with allogeneic…”
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