Critical Information from High Fidelity Arterial and Venous Pressure Waveforms During Anesthesia and Hemorrhage

Critical Information from High Fidelity Arterial and Venous Pressure Waveforms During Anesthesia and Hemorrhage

Purpose Peripheral venous pressure (PVP) waveform analysis is a novel, minimally invasive, and inexpensive method of measuring intravascular volume changes. A porcine cohort was studied to determine how venous and arterial pressure waveforms change due to inhaled and infused anesthetics and acute he...

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Published in:Cardiovascular engineering and technology Vol. 13; no. 6; pp. 886 - 898
Main Authors: Crimmins-Pierce, Lauren D., Bonvillain, Gabriel P., Henry, Kaylee R., Hayat, Md Abul, Villafranca, Adria Abella, Stephens, Sam E., Jensen, Hanna K., Sanford, Joseph A., Wu, Jingxian, Sexton, Kevin W., Jensen, Morten O.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-12-2022
Springer Nature B.V
Subjects:
Anesthesia
Anesthetics
Animals
Arterial Pressure
Arteries
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedical Engineering/Biotechnology
Biomedicine
Blood Pressure
Cardiology
Coefficient of variation
Correlation coefficients
Decision making
Heart rate
Hemorrhage
Hemorrhage - chemically induced
Measurement methods
Original Article
Swine
Variance analysis
Venous Pressure
Waveforms
Cross-talk between venous and arterial circulations
Peripheral venous pressure
Hemorrhage
Inhaled anesthetic
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Summary:Purpose Peripheral venous pressure (PVP) waveform analysis is a novel, minimally invasive, and inexpensive method of measuring intravascular volume changes. A porcine cohort was studied to determine how venous and arterial pressure waveforms change due to inhaled and infused anesthetics and acute hemorrhage. Methods Venous and arterial pressure waveforms were continuously collected, while each pig was under general anesthesia, by inserting Millar catheters into a neighboring peripheral artery and vein. The anesthetic was varied from inhaled to infused, then the pig underwent a controlled hemorrhage. Pearson correlation coefficients between the power of the venous and arterial pressure waveforms at each pig’s heart rate frequency were calculated for each variation in the anesthetic, as well as before and after hemorrhage. An analysis of variance (ANOVA) test was computed to determine the significance in changes of the venous pressure waveform means caused by each variation. Results The Pearson correlation coefficients between venous and arterial waveforms decreased as anesthetic dosage increased. In an opposing fashion, the correlation coefficients increased as hemorrhage occurred. Conclusion Anesthetics and hemorrhage alter venous pressure waveforms in distinctly different ways, making it critical for researchers and clinicians to consider these confounding variables when utilizing pressure waveforms. Further work needs to be done to determine how best to integrate PVP waveforms into clinical decision-making.
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ISSN:1869-408X
1869-4098
DOI:10.1007/s13239-022-00624-4