Search Results - "Bonsi, P."

Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia by Eskow Jaunarajs, K L, Bonsi, P, Chesselet, M F, Standaert, D G, Pisani, A

“…Dystonia is a movement disorder of both genetic and non-genetic causes, which typically results in twisted posturing due to abnormal muscle contraction…”
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Rescue of striatal long-term depression by chronic mGlu5 receptor negative allosteric modulation in distinct dystonia models by Martella, G., Bonsi, P., Imbriani, P., Sciamanna, G., Nguyen, H., Yu-Taeger, L., Schneider, M., Poli, S.M., Lütjens, R., Pisani, A.

“…An impairment of long-term synaptic plasticity is considered as a peculiar endophenotype of distinct forms of dystonia, a common, disabling movement disorder…”
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Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition by Maltese, M., Martella, G., Imbriani, P., Schuermans, Jeroen, Billion, Karolien, Sciamanna, G., Farook, Febin, Ponterio, G., Tassone, A., Santoro, M., Bonsi, P., Pisani, A., Goodchild, Rose E.

“…Striatal dysfunction is implicated in many movement disorders. However, the precise nature of defects often remains uncharacterized, which hinders therapy…”
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Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia by Martella, G, Maltese, M, Nisticò, R, Schirinzi, T, Madeo, G, Sciamanna, G, Ponterio, G, Tassone, A, Mandolesi, G, Vanni, V, Pignatelli, M, Bonsi, P, Pisani, A

“…Abstract DYT1 dystonia is a movement disorder caused by a deletion in the C-terminal of the protein torsinA. It is unclear how torsinA mutation might disrupt…”
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Models of dystonia: an update by Imbriani, P., Ponterio, G., Tassone, A., Sciamanna, G., El Atiallah, I., Bonsi, P., Pisani, A.

“…•Dystonia is a frequent movement disorder.•DYT1 is the most common form of inherited dystonias.•Multiple animal models of DYT1 dystonia have been generated.•A…”
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Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice by Martella, G, Madeo, G, Maltese, M, Vanni, V, Puglisi, F, Ferraro, E, Schirinzi, T, Valente, E.M, Bonanni, L, Shen, J, Mandolesi, G, Mercuri, N.B, Bonsi, P, Pisani, A

“…Abstract Heterozygous mutations in the PINK1 gene are considered a susceptibility factor to develop early-onset Parkinson's disease (PD), as supported by…”
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Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum by Ponterio, G., Tassone, A., Sciamanna, G., Riahi, E., Vanni, V., Bonsi, P., Pisani, A.

“…Cholinergic interneurons (ChIs) of dorsal striatum play a key role in motor control and in behavioural learning. Neuropeptides regulate cholinergic…”
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Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia by Pisani, A., Martella, G., Tscherter, A., Bonsi, P., Sharma, N., Bernardi, G., Standaert, D.G.

“…Early-onset torsion dystonia (DYT1) is an autosomal dominant disease caused by a deletion in the gene encoding the protein torsinA. Recently, a transgenic…”
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Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia by Sciamanna, G., Ponterio, G., Tassone, A., Maltese, M., Madeo, G., Martella, G., Poli, S., Schirinzi, T., Bonsi, P., Pisani, A.

“…Early onset torsion dystonia (DYT1) is an autosomal dominantly inherited disorder caused by deletion in TOR1A gene. Evidence suggests that TOR1A mutation…”
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Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice by Madeo, G., Schirinzi, T., Maltese, M., Martella, G., Rapino, C., Fezza, F., Mastrangelo, N., Bonsi, P., Maccarrone, M., Pisani, A.

“…Recessive mutations in the PTEN-induced putative kinase 1 (PINK1) gene cause early-onset Parkinson's disease (PD). We investigated the interaction between…”
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Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl- D-aspartate responses in medium spiny striatal neurons by Pisani, A, Gubellini, P, Bonsi, P, Conquet, F, Picconi, B, Centonze, D, Bernardi, G, Calabresi, P

“…Medium spiny neurons were recorded from striatal slices obtained from mice lacking the group I metabotropic glutamate receptor (mGluR) subtype 1 or subtype 5…”
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Aberrant striatal synaptic plasticity in monogenic parkinsonisms by Madeo, G, Martella, G, Schirinzi, T, Ponterio, G, Shen, J, Bonsi, P, Pisani, A

“…Abstract In the recent past, the pathogenesis of Parkinson's disease (PD) has evolved from a neurodegenerative disorder considered entirely sporadic to a…”
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Toxicity of Selected Plant Volatiles in Microbial and Mammalian Short-term Assays by Stammati, A., Bonsi, P., Zucco, F., Moezelaar, R., Alakomi, H.-L., von Wright, A.

“…In this study, several short-term microbial and mammalian in vitro assays were used to evaluate cytotoxicity and genotoxicity of four plant volatiles showing…”
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Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease by Bonsi, P, Cuomo, D, Picconi, B, Sciamanna, G, Tscherter, A, Tolu, M, Bernardi, G, Calabresi, P, Pisani, A

“…Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopamine (DA)-containing neurons in the substantia nigra pars…”
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Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons by Bonsi, P., Cuomo, D., De Persis, C., Centonze, D., Bernardi, G., Calabresi, P., Pisani, A.

“…Within basal ganglia, group I metabotropic glutamate receptor subtypes (mGluR1 and 5) frequently co-localize in the same neuron. However, little is known about…”
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Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease by Martella, G, Madeo, G, Schirinzi, T, Tassone, A, Sciamanna, G, Spadoni, F, Stefani, A, Shen, J, Pisani, A, Bonsi, P

“…Abstract In the present work we analyzed the profile of high voltage-activated (HVA) calcium (Ca2+ ) currents in freshly isolated striatal medium spiny neurons…”
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Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin by Martella, G., Platania, P., Vita, D., Sciamanna, G., Cuomo, D., Tassone, A., Tscherter, A., Kitada, T., Bonsi, P., Shen, J., Pisani, A.

“…An altered glutamatergic input at corticostriatal synapses has been shown in experimental models of Parkinson's disease (PD). In the present work, we analyzed…”
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Distinct roles of group I mGlu receptors in striatal function by Bonsi, P., Platania, P., Martella, G., Madeo, G., Vita, D., Tassone, A., Bernardi, G., Pisani, A.

“…In the recent past, evidence accumulated in favour of a central role of group I metabotropic glutamate (mGlu) receptors, mGlu1 and mGlu5, in the modulation of…”
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Targeting striatal cholinergic interneurons in Parkinson’s disease: Focus on metabotropic glutamate receptors by Pisani, A., Bonsi, P., Centonze, D., Gubellini, P., Bernardi, G., Calabresi, P.

“…In the early sixties, anticholinergic drugs were introduced in the pharmacological treatment of Parkinson’s disease (PD). The rationale behind their…”
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Activation of D2-Like Dopamine Receptors Reduces Synaptic Inputs to Striatal Cholinergic Interneurons by Pisani, Antonio, Bonsi, Paola, Centonze, Diego, Calabresi, Paolo, Bernardi, Giorgio

“…Dopamine (DA) plays a crucial role in the modulation of striatal function. Striatal cholinergic interneurons represent an important synaptic target of…”
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