Search Results - "Bonora, Gian Maria"

Antiproliferative activity of a triplex-forming oligonucleotide recognizing a Ki-ras polypurine/polypyrimidine motif correlates with protein binding by Cogoi, Susanna, Ballico, Maurizio, Bonora, Gian-Maria, Xodo, Luigi E

“…The Ki-ras gene is frequently mutated and/or overexpressed in human cancer. Since it is suspected to play a key role in the pathogenesis of many tumors, there…”
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Interchangeable PEG-Supported Synthesis of Peptide-Oligonucleotide Chimeras by Adamo, Ilaria, Ballico, Maurizio, Campaner, Pietro, Drioli, Sara, Bonora, Gian Maria

“…A procedure has been developed for the preparation of peptide‐PEG‐oligonucleotide conjugates: the two sequences were synthesized at the extremities of the same…”
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Multimeric, Multifunctional Derivatives of Poly(ethylene glycol) by Zacchigna, Marina, Cateni, Francesca, Drioli, Sara, Bonora, Gian Maria

“…This article reviews the use of multifunctional polymers founded on high-molecular weight poly(ethylene glycol) (PEG). The design of new PEG derivatives…”
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Pegylated TRAIL retains anti-leukemic cytotoxicity and exhibits improved signal transduction activity with respect to TRAIL by Gonelli, Arianna, Radillo, Oriano, Drioli, Sara, Rimondi, Erika, Secchiero, Paola, Maria Bonora, Gian

“…Summary To improve the pharmacokinetic profile of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) an N-terminal specific pegylation was…”
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Conjugated PDT drug: Photosensitizing activity and tissue distribution of PEGylated pheophorbide a by Rapozzi, Valentina, Zacchigna, Marina, Biffi, Stefania, Garrovo, Chiara, Cateni, Francesca, Stebel, Marco, Zorzet, Sonia, Bonora, Gian Maria, Drioli, Sara, Xodo, Luigi

“…The design of new photosensitizers with enhanced phototoxicity and pharmacokinetic properties remains a central challenge for cancer photodynamic therapy…”
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Antigene Effect in K562 Cells of a PEG-Conjugated Triplex-Forming Oligonucleotide Targeted to the bcr/abl Oncogene by Rapozzi, Valentina, Cogoi, Susanna, Spessotto, Paola, Risso, Angela, Bonora, Gian Maria, Quadrifoglio, Franco, Xodo, Luigi Emilio

“…Triplex-forming oligonucleotides are able to modulate gene expression by site-specific binding to genomic DNA. Their use as therapeutic agents is limited by…”
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Synthesis and Characterization of High-Molecular Mass Polyethylene Glycol-Conjugated Oligonucleotides by Bonora, Gian Maria, Ivanova, Eugenia, Zarytova, Valentina, Burcovich, Barbara, Veronese, Francesco Maria

“…The use of synthetic oligonucleotides as possible drugs for human therapy is usually hampered by their low in vivo stability and capacity to achieve high…”
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Pure, homo-bifunctional poly(ethylene glycol) orthogonally protected: synthesis and characterisation by Drioli, Sara, Benedetti, Fabio, Bonora, Gian Maria

“…New orthogonal reversible protections have been introduced on high-molecular weight, di-hydroxy PEGs. The introduction on the reaction intermediates of a…”
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Conformations of poly(ethylene glycol) bound homooligo-L-alanines and -L-valines in aqueous solution by Toniolo, Claudio, Bonora, Gian Maria, Mutter, Manfred

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Conformational Characterization of the 1-Aminocyclobutane-1-carboxylic Acid Residue in Model Peptides by Gatos, Maddalena, Formaggio, Fernando, Crisma, Marco, Toniolo, Claudio, Bonora, Gian Maria, Benedetti, Zettore, Di Blasio, Benedetto, Iacovino, Rosa, Santini, Antonello, Saviano, Michele, Kamphuis, Johan

“…A series of N‐ and C‐protected, monodispersed homo‐oligopeptides (to the dodecamer level) from the small‐ring alicyclic Cα,α‐dialkylated glycine…”
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HELP (high efficiency liquid phase) new oligonucleotide synthesis on soluble polymeric support by BONORA, G. M, SCREMIN, C. L, COLONNA, F. P, GARBESI, A

“…A simple, rapid and high-yielding method for the synthesis of oligonucleotides by the phosphotriesters approach is described. The use of polyethylene glycol…”
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Linear oligopeptides. 81. Solid-state and solution conformation of homooligo(.alpha.-aminoisobutyric acids) from tripeptide to pentapeptide: evidence for a 310 helix by Benedetti, Ettore, Bavoso, Alfonso, Di Blasio, Benedetto, Pavone, Vincenzo, Pedone, Carlo, Crisma, Marco, Bonora, Gian Maria, Toniolo, Claudio

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Long Polypeptide 310-helices at Atomic Resolution by Bavoso, Alfonso, Benedetti, Ettore, Di Blasio, Benedetto, Pavone, Vincenzo, Pedone, Carlo, Toniolo, Claudio, Bonora, Gian Maria

“…The crystal-state preferred conformation of the terminally blocked homooctapeptide from the Cα,α-dimetylated α -aminoisobutyric acid (Aib) residue, pBrBz-…”
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Pharmacokinetic analysis of multi PEG–theophylline conjugates by Grassi, Mario, Bonora, Gian Maria, Drioli, Sara, Cateni, Francesca, Zacchigna, Marina

“…[Display omitted] ► Prolonged theophylline effect if administered as a multimeric PEG-drug solution. ► Reliable mathematical model for the PK data…”
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New MultiPEG-conjugated theophylline derivatives: Synthesis and pharmacological evaluations by Zacchigna, Marina, Di Luca, Gabriella, Cateni, Francesca, Maurich, Venerando, Ballico, Maurizio, Bonora, Gian Maria, Drioli, Sara

“…The successful conjugation of active theophylline molecules to two new multifunctional high-molecular weight poly(ethylene glycol) derivatives (MultiPEG) and…”
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Large-scale preparation of conjugated oligonucleoside phosphorothioates by the high-efficiency liquid-phase (HELP) method by Bonora, Gian Maria

“…A new process for the preparation of large amounts of thioated oligonucleotides in a quasi-classical solution condition is described. This method takes…”
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Chain-length dependence for secondary structure formation of poly(ethylene glycol)-bound homooligopeptides of .epsilon.-benzyloxycarbonyl-L-lysine in the solid state and in solution by Toniolo, Claudio, Bonora, Gian Maria, Anzinger, Hermann, Mutter, Manfred

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PNA Conjugated to High-Molecular Weight Poly(Ethylene Glycol): Synthesis and Properties by Bonora, Gian Maria, Drioli, Sara, Ballico, Maurizio, Faccini, Andrea, Corradini, Roberto, Cogoi, Susanna, Xodo, Luigi

“…The conjugation of a bioactive, fluorescent PNA sequence to high-molecular weight poly(ethylene glycol) (PEG) is described and the properties of the PEG-PNA…”
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Polymer-Conjugated Bioactive Oligonucleotides by Bonora, Gian Maria

“…This paper presents our most recent investigations on the effect of a soluble, inert polymer as a conjugating agent for synthetic oligonucleotides. In…”
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Conformational properties of methionine homo-oligopeptides in solution by Bonora, G M, Toniolo, C

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