Search Results - "Bonney, Robert J."

Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents by Firestone, Raymond A, Pisano, Judith M, Bonney, Robert J

“…Amines whose pK values lie between about 5 and 9 are lysosomotropic because lysosomes are acidic intracellular compartments. If such amines bear long…”
Get full text

Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol by Finke, Paul E, Shah, Shrenik K, Ashe, Bonnie M, Ball, Richard G, Blacklock, Thomas J, Bonney, Robert J, Brause, Karen A, Chandler, Gilbert O, Cotton, Meredith

“…Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of…”
Get full text

Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase by Doherty, James B, Ashe, Bonnie M, Argenbright, Lawrence W, Barker, Peter L, Bonney, Robert J, Chandler, Gilbert O, Dahlgren, Mary Ellen, Dorn, Conrad P, Finke, Paul E, Firestone, Raymond A, Fletcher, Daniel, Hagmann, William K, Mumford, Richard, O'Grady, Laura, Maycock, Alan L, Pisano, Judith M, Shah, Shrenik K, Thompson, Kevan R, Zimmerman, Morris

“…Several laboratories, including our own have reported the synthesis and activity of certain low relative molecular mass inhibitors of mammalian serine…”
Get full text

Physiological and pharmacological regulation of prostaglandin and leukotriene production by macrophages by Bonney, R J, Humes, J L

“…The synthesis and secretion of prostaglandins and leukotrienes by mouse peritoneal macrophages is under several regulatory controls. Arachidonic acid must…”
Get more information

Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages by Humes, J L, Sadowski, S, Galavage, M, Goldenberg, M, Subers, E, Kuehl, Jr, F A, Bonney, R J

“…Resident mouse peritoneal macrophages, exposed to zymosan, synthesized and released products of both the cyclooxygenase and lipoxygenase pathways. The effects…”
Get more information

Phospholipase activity in skin after application of phorbol esters and 3-methylcholanthrene by Bresnick, E, Bailey, G, Bonney, R J, Wightman, P

“…Topical administration of the promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is accompanied by an increased incorporation of [3H]arachidonic acid into…”
Get more information

Primary Monolayer Cultures of Adult Rat Liver Parenchymal Cells Suitable for Study of the Regulation of Enzyme Synthesis by Bonney, Robert J., Becker, Joyce E., Walker, P. Roy, Potter, Van R.

“…Parenchymal cells from adult rat liver which had been fully regenerated were isolated and cultured in nonproliferating monolayers in vitro. The optimum…”
Get full text

Effect of methotrexate on thymidylate synthetase in cultured parenchymal cells isolated from regenerating rat liver by Bonney, R J, Maley, F

“…The effect of methotrexate (MTX) on thymidylate synthetase activity during liver regeneration was examined with parenchymal cells isolated 22 and 44 hr after…”
Get full text

Lysosomotropic agents. 4. Carbobenzoxyglycylphenylalanyl, a new protease-sensitive masking group for introduction into cells by Firestone, Raymond A, Pisano, Judith M, Bailey, Philip J, Sturm, Anita, Bonney, Robert J, Wightman, Paul, Devlin, Richard, Lin, C. Shirley, Keller, Doris L, Tway, Patricia C

“…Bioactive primary and secondary amines, when acylated with the Z-Gly-Phe group, are transported into pinocytic cells, such as macrophages, P-815 mastocytoma,…”
Get full text

Regulation of Thymidine Metabolism in Escherichia coli K-12: Evidence That at Least Two Operons Control the Degradation of Thymidine by Bonney, R J, Weinfeld, H

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Regulation of Thymidine Metabolism in Escherichia coli K-12: Optimal Conditions for the Assay of 1,5-Phosphodeoxyribomutase in Ultrasonic Extracts by Bonney, R J, Weinfeld, H

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Regulation of Thymidine Metabolism in Escherichia coli K-12: Studies on the Inducer and the Coordinateness of Induction of the Enzymes by Bonney, R J, Weinfeld, H

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase by Doherty, James B., Shah, Shrenik K., Finke, Paul E., Dorn, Conrad P., Hagmann, William K., Hale, Jeffrey J., Kissinger, Amy L., Thompson, Kevan R., Brause, karen, Chandler, Gilbert O., Knight, Wilson B., Maycock, Alan L., Ashe, Bonnie M., Weston, Hazel, Gale, Paul, Mumford, Richard A., Andersen, O. Frederick, Williams, Hollis R., Nolan, Thomas E., Frankenfield, Dale L., Underwood, Dennis, Vyas, Kamlesh P., Kari, Prasad H., Dahlgren, Mary E., Mao, Jennifer, Fletcher, Daniel S., Pa. S. Dellea, Hand, Karen M., Osinga, Donald G., Peterson, Laurence B., Williams, Dorsey T., Metzger, Joseph M., Bonney, Robert J., Humes, John L., Pacholok, Steven P., Hanlon, William A., Opas, Evan, Stolk, Jan, Davies, Philip

“…A series of potent and highly selective time-dependent monocyclic β-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is…”
Get full text

Prostaglandin and Leukotriene Synthesis in Mouse Ears Inflamed by Arachidonic Acid by Opas, Evan E., Bonney, Robert J., Humes, John L.

“…Topical application of arachidonic acid on mouse ears induces the synthesis of prostaglandin E2 and leukotrienes C4 and D4. The increased tissue levels of…”
Get full text

Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent by Hammond, Milton L, Zambias, Robert A, Chang, Michael N, Jensen, Norman P, McDonald, John, Thompson, Kathryn, Boulton, David A, Kopka, Ihor E, Hand, Karen M

“…The leukotrienes, metabolites of arachidonic acid produced through the action of the enzyme 5-lipoxygenase, are important mediators of immediate…”
Get full text

Antigen-antibody complexes stimulate the synthesis and release of prostaglandins by mouse peritoneal macrophages by Bonney, R J, Naruns, P, Davies, P, Humes, J L

“…Antigen-antibody complexes (Ag/Ab) formed at equivalence stimulate the release of arachidonic acid and synthesis of prostaglandin E2 and 6-keto-prostaglandin…”
Get more information

Potency of antileukoprotease and alpha 1-antitrypsin to inhibit degradation of fibrinogen by adherent polymorphonuclear leukocytes from normal subjects and patients with chronic granulomatous disease by Stolk, J, Davies, P, Kramps, J A, Dijkman, J H, Humes, J J, Knight, W B, Green, B G, Mumford, R, Bonney, R J, Hanlon, W A

“…We have studied the relative efficacy of antileukoprotease (ALP) and alpha 1-antitrypsin (alpha 1AT) to inhibit the degradation of substrate by…”
Get more information

Adult Liver Parenchymal Cells in Primary Culture: Characteristics and Cell Recognition Standards by Bonney, Robert J.

Get full text

Extended expression of differentiated function in primary cultures of adult liver parenchymal cells maintained on nitrocellulose filters. I. Induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by Savage, Jr, C R, Bonney, R J

Get more information

Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent by Bonney, R J, Davies, P, Dougherty, H, Egan, R W, Gale, P H, Chang, M, Hammond, M, Jensen, N, MacDonald, J, Thompson, K

“…The biochemical and biological profile of a topical anti-inflammatory agent, 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896…”
Get more information