Search Results - "Bonnett, Shilah"

A class of hydrazones are active against non-replicating Mycobacterium tuberculosis by Bonnett, Shilah A, Dennison, Devon, Files, Megan, Bajpai, Anumita, Parish, Tanya

“…There is an urgent need for the development of shorter, simpler and more tolerable drugs to treat antibiotic tolerant populations of Mycobacterium…”
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Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase by Melief, Eduard, Bonnett, Shilah A, Zuniga, Edison S, Parish, Tanya

“…The diaminoquinazoline series has good potency against Resistant isolates have mutations in Rv3161c, a putative dioxygenase. We carried out metabolite analysis…”
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Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids by Kancharla, Papireddy, Bonnett, Shilah A., Reynolds, Kevin A.

“…The bacterial pathway of olefin biosynthesis starts with OleA catalyzed “head‐to‐head” condensation of two CoA‐activated long‐chain fatty acids to generate…”
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Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis by Punetha, Ankita, Ngo, Huy X, Holbrook, Selina Y L, Green, Keith D, Willby, Melisa J, Bonnett, Shilah A, Krieger, Kyle, Dennis, Emily K, Posey, James E, Parish, Tanya, Tsodikov, Oleg V, Garneau-Tsodikova, Sylvie

“…The enhanced intracellular survival (Eis) protein of ( ) is a versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their…”
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Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB by Paranagama, Naduni, Bonnett, Shilah A, Alvarez, Jonathan, Luthra, Amit, Stec, Boguslaw, Gustafson, Andrew, Iwata-Reuyl, Dirk, Swairjo, Manal A

“…Guanosine 5'-triphosphate (GTP) cyclohydrolase-I (GCYH-I) catalyzes the first step in folic acid biosynthesis in bacteria and plants, biopterin biosynthesis in…”
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Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth by de Oliveira, Josiane A. Monteiro, Williams, David E., Bonnett, Shilah, Johnson, James, Parish, Tanya, Andersen, Raymond J.

“…Crude extracts of the marine sponge Chelonaplysilla sp. collected in Samoa, that were obtained from the NCI Open Repository (NCS 21903), inhibited…”
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34 Multi-step antibody validation for the geomx® digital spatial profiler by Rosenbloom, Alyssa, Cronin, Jenny, Bonnett, Shilah

“…BackgroundUnderstanding protein expression patterns within tissue compartments is imperative to investigating a range of biological questions. Historically,…”
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Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis by Bonnett, Shilah, Jee, Jo-Ann, Chettiar, Somsundaram, Ovechkina, Yulia, Korkegian, Aaron, Greve, Eric, Odingo, Joshua, Parish, Tanya

“…We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal…”
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Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth by Ray, Peter C, Huggett, Margaret, Turner, Penelope A, Taylor, Malcolm, Cleghorn, Laura A. T, Early, Julie, Kumar, Anuradha, Bonnett, Shilah A, Flint, Lindsay, Joerss, Douglas, Johnson, James, Korkegian, Aaron, Mullen, Steven, Moure, Abraham L, Davis, Susan H, Murugesan, Dinakaran, Mathieson, Michael, Caldwell, Nicola, Engelhart, Curtis A, Schnappinger, Dirk, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Massoudi, Lisa, Robertson, Gregory T, Lenaerts, Anne J, Freiberg, Gail, Kempf, Dale J, Masquelin, Thierry, Hipskind, Philip A, Odingo, Joshua, Read, Kevin D, Green, Simon R, Wyatt, Paul G, Parish, Tanya

“…With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action…”
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Functional Modular Dissection of DEBS1-TE Changes Triketide Lactone Ratios and Provides Insight into Acyl Group Loading, Hydrolysis, and ACP Transfer by Yan, John, Hazzard, Christopher, Bonnett, Shilah A, Reynolds, Kevin A

“…The DEBS1-TE fusion protein is comprised of the loading module, the first two extension modules, and the terminal TE domain of the Saccharopolyspora erythraea…”
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Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles by Bonnett, Shilah A, Rosenbloom, Alyssa B, Ong, Giang T, Conner, Mark, Rininger, Aric B E, Newhouse, Daniel, New, Felicia, Phan, Chi Q, Ilcisin, Saskia, Sato, Hiromi, Lyssand, John S, Geiss, Gary, Beechem, Joseph M

“…A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of…”
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120 Human immuno-oncology proteome atlas enables a holistic proteomic approach for spatial biology discovery in FFPE tissues by Rosenbloom, Alyssa, Bonnett, Shilah, Conner, Mark, Piazza, Erin, Filanoski, Brian, Meredith, Rhonda, Yi, Hye Son, Hamanishi, Lori, Ignacio, Eduardo, Nelson, Nadine, Prater, Michael, Kang, Christine, Isgur, Lesley, Hoang, Margaret, Geiss, Gary, Beechem, Joseph

“…BackgroundThe advancement of spatially resolved, multiplex proteomic and transcriptomic technologies has revolutionized and redefined the approaches to complex…”
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Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB by SANKARAN, Banumathi, BONNETT, Shilah A, SWAIRJO, Manal A, SHAH, Kinjal, GABRIEL, Scott, REDDY, Robert, SCHIMMEL, Paul, RODIONOV, Dmitry A, DE CRECY-LAGARD, Valérie, HELMANN, John D, IWATA-REUYL, Dirk

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Functional Characterization of an NADPH Dependent 2-Alkyl-3-ketoalkanoic Acid Reductase Involved in Olefin Biosynthesis in Stenotrophomonas maltophilia by Bonnett, Shilah A, Papireddy, Kancharla, Higgins, Samuel, del Cardayre, Stephen, Reynolds, Kevin A

“…OleD is shown to play a key reductive role in the generation of alkenes (olefins) from acyl thioesters in Stenotrophomonas maltophilia. The gene coding for…”
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207 The spatially-resolved proteomic atlas of the tumor immune architecture of HER2-positive breast cancer and response to neoadjuvant anti-HER2 therapy-based chemotherapy by Chumsri, Saranya, Kachergus, Jennifer, Shi, Ji, Liu, Yi, Ma, Yaohua, Rosenbloom, Alyssa, Bonnett, Shilah, Conner, Mark, Piazza, Erin, Filanoski, Brian, Meredith, Rhonda, Kang, Christine, Isgur, Lesley, Hoang, Margaret, Geiss, Gary, Beechem, Joseph, Thompson, EA

“…BackgroundThe standard of care for early-stage HER2-positive (HER2+) breast cancer is neoadjuvant anti-HER2 therapy-based chemotherapy, with the preferred…”
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A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase by Bonnett, Shilah A, Ollinger, Juliane, Chandrasekera, Susantha, Florio, Stephanie, O’Malley, Theresa, Files, Megan, Jee, Jo-Ann, Ahn, James, Casey, Allen, Ovechkina, Yulia, Roberts, David, Korkegian, Aaron, Parish, Tanya

“…The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane…”
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Discovery of a New Prokaryotic Type I GTP Cyclohydrolase Family by El Yacoubi, Basma, Bonnett, Shilah, Anderson, Jessica N., Swairjo, Manal A., Iwata-Reuyl, Dirk, de Crécy-Lagard, Valérie

“…GTP cyclohydrolase I (GCYH-I) is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in…”
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Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene by Bonnett, Shilah A., Whicher, Jonathan R., Papireddy, Kancharla, Florova, Galina, Smith, Janet L., Reynolds, Kevin A.

“…The formation of an activated cis-3-cyclohexylpropenoic acid by Plm1, the first extension module of the phoslactomycin polyketide synthase, is proposed to…”
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Ultra High‐Plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles by Bonnett, Shilah, Rosenbloom, Alyssa, Ong, Giang, Conner, Mark, Newhouse, Daniel, New, Felicia, Sato, Hiromi, Phan, Chi, Ilcisin, Saskia, Lyssand, John, Geiss, Gary, Beechem, Joseph M.

“…Background The advancement of spatially resolved, multiplex proteomic and transcriptomic technologies has revolutionized and redefined the approaches to…”
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A complete pipeline for high‐plex spatial proteomic profiling and analysis of neural cell phenotypes on the CosMx™ Spatial Molecular Imager and AtoMx™ Spatial Informatics Platform by Rosenbloom, Alyssa, Bonnett, Shilah, Conner, Mark, Phan‐Everson, Tien, Lewis, Zachary, Ong, Giang, Liang, Yan, Brown, Emily, Pan, Liuliu, Wardhani, Aster, Korukonda, Mithra, Brown, Carl, Dunaway, Dwayne, Zhao, Edward, McGuire, Dan, Woo, Sangsoon, Filanoski, Brian, Meredith, Rhonda, Chantranuvatana, Kan, Birditt, Brian, Yi, Hye Son, Piazza, Erin, Reeves, Jason, Kang, Christine, Geiss, Gary, Beechem, Joseph M.

“…Background The brain is complex and heterogeneous where cell function and cell‐to‐cell communication are critical for rapid and accurate performance. The…”
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