Search Results - "Bonnard, Benjamin"

Roles of Mineralocorticoid Receptors in Cardiovascular and Cardiorenal Diseases by Barrera-Chimal, Jonatan, Bonnard, Benjamin, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological effects, such as excessive extracellular matrix accumulation,…”
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Mineralocorticoid Receptor and Cardiovascular Disease by Buonafine, Mathieu, Bonnard, Benjamin, Jaisser, Frédéric

“…Abstract Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand, aldosterone, plays an important role in sodium reabsorption and…”
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Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway by Bonnard, Benjamin, Ibarrola, Jaime, Lima-Posada, Ixchel, Fernández-Celis, Amaya, Durand, Manon, Genty, Marie, Lopez-Andrés, Natalia, Jaisser, Frédéric

“…NGAL (neutrophil gelatinase-associated lipocalin; or lipocalin 2, Lcn2) is a novel mineralocorticoid target in the cardiovascular system. We showed that Lcn2…”
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Benefits of the Non-Steroidal Mineralocorticoid Receptor Antagonist Finerenone in Metabolic Syndrome-Related Heart Failure with Preserved Ejection Fraction by Lima-Posada, Ixchel, Stephan, Yohan, Soulié, Matthieu, Palacios-Ramirez, Roberto, Bonnard, Benjamin, Nicol, Lionel, Kolkhof, Peter, Jaisser, Frederic, Mulder, Paul

“…The mineralocorticoid receptor (MR) plays an important role in the development of chronic kidney disease (CKD) and associated cardiovascular complications…”
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Effect of acute and chronic aldosterone exposure on the retinal pigment epithelium-choroid complex in rodents by Canonica, Jérémie, Mehanna, Chadi, Bonnard, Benjamin, Jonet, Laurent, Gelize, Emmanuelle, Jais, Jean-Philippe, Jaisser, Frederic, Zhao, Min, Behar-Cohen, Francine

“…Preclinical and clinical evidences show that aldosterone and/or mineralocorticoid receptor (MR) over-activation by glucocorticoids can be deleterious to the…”
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Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice by Bonnard, Benjamin, Pieronne-Deperrois, Marie, Djerada, Zoubir, Elmoghrabi, Soumaya, Kolkhof, Peter, Ouvrard-Pascaud, Antoine, Mulder, Paul, Jaisser, Frédéric, Messaoudi, Smail

“…Managing the cardiovascular complications of renal failure is a major therapeutic challenge in clinical practice. Mineralocorticoid Receptor (MR) blockade is a…”
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Biglycan Is a Novel Mineralocorticoid Receptor Target Involved in Aldosterone/Salt-Induced Glomerular Injury by Nakamura, Toshifumi, Bonnard, Benjamin, Palacios-Ramirez, Roberto, Fernández-Celis, Amaya, Jaisser, Frédéric, López-Andrés, Natalia

“…The beneficial effects of mineralocorticoid receptor (MR) antagonists (MRAs) for various kidney diseases are established. However, the underlying mechanisms of…”
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Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Improves Diastolic Dysfunction in Preclinical Nondiabetic Chronic Kidney Disease by Lima Posada, Ixchel, Soulié, Matthieu, Stephan, Yohan, Palacios Ramirez, Roberto, Bonnard, Benjamin, Nicol, Lionel, Pitt, Bertram, Kolkhof, Peter, Mulder, Paul, Jaisser, Frederic

“…The mineralocorticoid receptor plays a significant role in the development of chronic kidney disease (CKD) and associated cardiovascular complications. Classic…”
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Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice by Palacios-Ramirez, Roberto, Lima-Posada, Ixchel, Bonnard, Benjamin, Genty, Marie, Fernandez-Celis, Amaya, Hartleib-Geschwindner, Judith, Foufelle, Fabienne, Lopez-Andres, Natalia, Bamberg, Krister, Jaisser, Frederic

“…Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to…”
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Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve by Ibarrola, Jaime, Garaikoetxea, Mattie, Garcia-Peña, Amaia, Matilla, Lara, Jover, Eva, Bonnard, Benjamin, Cuesta, Maria, Fernández-Celis, Amaya, Jaisser, Frederic, López-Andrés, Natalia

“…Mitral valve prolapse (MVP) patients develop myocardial fibrosis that is not solely explained by volume overload, but the pathophysiology has not been defined…”
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The Absence of Endothelial Sodium Channel α (αENaC) Reduces Renal Ischemia/Reperfusion Injury by Tarjus, Antoine, González-Rivas, Cecilia, Amador-Martínez, Isabel, Bonnard, Benjamin, López-Marure, Rebeca, Jaisser, Frédéric, Barrera-Chimal, Jonatan

“…The epithelial sodium channel (ENaC) has a key role in modulating endothelial cell stiffness and this in turn regulates nitric oxide (NO) synthesis. The…”
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Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models by Bonnard, Benjamin, Martínez-Martínez, Ernesto, Fernández-Celis, Amaya, Pieronne-Deperrois, Marie, Do, Quoc-Tuan, Ramos, Isbaal, Rossignol, Patrick, Zannad, Faiez, Mulder, Paul, Ouvrard-Pascaud, Antoine, López-Andrés, Natalia, Jaisser, Frédéric

“…Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological…”
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Abstract 129: Ngal Is A Novel Target In Hypertension By Modulating The Ncc-mediated Renal Na Balance by Jaisser, Frederic, Bonnard, Benjamin, Shimosawa, Tatsuo, Xhaard, Constance, rossignol, patrick

“…Abstract only Background: The expression of neutrophil gelatinase-associated lipocalin (NGAL/lcn2) is directly modulated by mineralocorticoid receptor…”
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Abstract P178: Mineralocorticoid Receptor Antagonism Improved the Metabolic Function in a Mouse Model With Chronic Kidney Disease and Obesity by Palacios Ramirez, Roberto, Bonnard, Benjamin, Jaisser, Frederic

“…Abstract only Introduction: Chronic kidney disease (CKD) is associated to cardiovascular and metabolic comorbidities. Several studies reported beneficial…”
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PS-B09-6: BIGLYCAN, A NEWLY IDENTIFIED MEDIATOR OF MINERALOCORTICOID RECEPTOR ACTIVATION-INDUCED NEPHROPATHY by Nakamura, Toshifumi, Bonnard, Benjamin, Ramirez, Roberto Palacios, Celis, Amaya Fernandez, Jaisser, Frederic, Andres, Natalia Lopez

“…Background: The activation of mineralocorticoid receptor (MR) is known to be involved in kidney disease progression. MR antagonists (MRAs) have been reported…”
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Abstract 080: The Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone Improves Diastolic Dysfunction In Preclinical Non-diabetic Chronic Kidney Disease by Lima Posada, Ixchel, STEPHAN, Yohan, Soulié, Matthieu, Palacios-Ramirez, Roberto, Bonnard, Benjamin, Kolkhof, Peter, Mulder, paul, Jaisser, Frederic

“…Abstract only Background: The mineralocorticoid receptor (MR) plays an important role in the development of Chronic Kidney Disease (CKD) and its overactivation…”
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NGAL is a Novel Target in Hypertension by Modulating the NCC-Mediated Renal Na Balance by Bonnard, Benjamin, El Moghrabi, Soumaya, Ueda, Kohei, Lattenist, Lionel, Soulie, Matthieu, López-Andrés, Natalia, Xhaard, Constance, Shimosawa, Tatsuo, Rossignol, Patrick, Jaisser, Frédéric

“…The expression of NGAL/lcn2 (neutrophil gelatinase-associated lipocalin) is directly modulated by mineralocorticoid receptor activation but its role in blood…”
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Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway by Palacios-Ramirez, Roberto, Soulié, Matthieu, Fernandez-Celis, Amaya, Nakamura, Toshifumi, Boujardine, Nabiha, Bonnard, Benjamin, Bamberg, Krister, Lopez-Andres, Natalia, Jaisser, Frederic

“…Excessive activation of the mineralocorticoid receptor (MR) is implicated in cardiovascular and renal disease. Decreasing MR activation with MR antagonists…”
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The Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Improves Left Ventricular Function in Preclinical CKD: FR-PO998 by Jaisser, Frederic, Posada, Ixchel Q. Lima, Stephan, Yohan, Soulié, Matthieu, Ramirez, Roberto Palacios, Bonnard, Benjamin, Nicol, Lionel, Kolkhof, Peter, Mulder, Paul

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METABOLIC EFFECT OF A MINERALOCORTICOID RECEPTOR ANTAGONIST IN A NEW MODEL OF DIABETIC NEPHROPATHY by Palacios, Roberto, Bonnard, Benjamin, Lima-Posada, Ixchel, Genty, Marie, Jaisser, Frederic

“…Objective: Diabetic nephropathy (DN) is the most prevalent form of chronic kidney disease (CKD) and is associated with cardiovascular diseases. Several studies…”
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