Search Results - "Bonjoch, Josep"

Radical Reactions in Alkaloid Synthesis: A Perspective from Carbon Radical Precursors by Bonjoch, Josep, Diaba, Faiza

“…The usefulness of radical reactions in alkaloid synthesis is reviewed from the perspective of the functional groups embedded in the molecular structure of…”
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Synthesis of the Tetracyclic ABCD Ring Domain of Calyciphylline A-Type Alkaloids via Reductive Radical Cyclizations by Coussanes, Guilhem, Bonjoch, Josep

“…A tetracyclic compound with the ABCD ring framework of calyciphylline A-type alkaloids was synthesized from a cis-3a-methyloctahydroindole triggered by a…”
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Radical Cyclization of Alkene‐Tethered Ketones Initiated by Hydrogen‐Atom Transfer by Saladrigas, Mar, Bosch, Caroline, Saborit, Gisela V., Bonjoch, Josep, Bradshaw, Ben

“…An unprecedented C−C coupling reaction between alkenes and ketones by hydrogen‐atom transfer, using Fe(acac)3 and PhSiH3 in EtOH, is described. This mild…”
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A gram-scale route to phlegmarine alkaloids: rapid total synthesis of (-)-cermizine B by Bradshaw, Ben, Luque-Corredera, Carlos, Bonjoch, Josep

“…The synthesis of the Lycopodium alkaloid (-)-cermizine B (1), which establishes its absolute configuration, is achieved by combining asymmetric organocatalysis…”
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Decahydroquinoline Ring 13C NMR Spectroscopic Patterns for the Stereochemical Elucidation of Phlegmarine-Type Lycopodium Alkaloids: Synthesis of (−)-Serralongamine A and Structural Reassignment and Synthesis of (−)-Huperzine K and (−)-Huperzine M (Lycoposerramine Y) by Bosch, Caroline, Bradshaw, Ben, Bonjoch, Josep

“…Analysis of 13C NMR spectroscopic data of the phlegmarine subset of Lycopodium alkaloids revealed spectral patterns that allowed the stereochemical arrangement…”
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Atom Transfer Radical Cyclization of Trichloroacetamides to Electron-Rich Acceptors Using Grubbs’ Catalysts: Synthesis of the Tricyclic Framework of FR901483 by Diaba, Faïza, Martínez-Laporta, Agustín, Bonjoch, Josep

“…Intramolecular Kharasch-type additions of trichloroacetamides on anisole and enol acetates catalyzed by Grubbs’ ruthenium carbenes are described. This protocol…”
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Approach to cis-Phlegmarine Alkaloids via Stereodivergent Reduction: Total Synthesis of (+)-Serratezomine E and Putative Structure of (−)-Huperzine N by Bosch, Caroline, Fiser, Béla, Gómez-Bengoa, Enrique, Bradshaw, Ben, Bonjoch, Josep

“…A unified strategy for the synthesis of the cis-phlegmarine group of alkaloids is presented, leading to the first synthesis of serratezomine E (1) as well as…”
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Radical Cyclizations in the Synthesis of 3‐Methyl‐cis‐octahydroindol‐5‐ones by Jansana, Sergi, Coussanes, Guilhem, Diaba, Faïza, Bonjoch, Josep

“…Three approaches to the stereoselective synthesis of 3‐methyl‐cis‐octahydroindoles through a 5‐endo‐trig radical cyclization are described. First, starting…”
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Synthesis of the ABC fragment of calyciphylline A-type Daphniphyllum alkaloids by Diaba, Faïza, Martínez-Laporta, Agustín, Coussanes, Guilhem, Fernández, Israel, Bonjoch, Josep

“…The ABC-ring system of calyciphylline A-type alkaloids has been synthesized. The key steps of the synthetic approach are an atom transfer radical cyclization…”
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Synthesis of (±)-Serralongamine A and the Revised Structure of Huperzine N by Saborit, Gisela V, Bosch, Caroline, Parella, Teodor, Bradshaw, Ben, Bonjoch, Josep

“…A revised structure for the Lycopodium alkaloid huperzine N is proposed and confirmed by synthesis. The key synthetic steps involve an epimerization of a…”
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Synthesis of cis -hydrindan-2,4-diones bearing an all-carbon quaternary center by a Danheiser annulation by Saborit, Gisela V, Cativiela, Carlos, Jiménez, Ana I, Bonjoch, Josep, Bradshaw, Ben

“…A straightforward synthetic entry to functionalized hydrindane compounds based on a rapid assembly of the core nucleus by a Danheiser cycloaddition is…”
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Synthesis of the 4-Azatricyclo[5.2.2.04,8]undecan-10-one Core of Daphniphyllum Alkaloid Calyciphylline A Using a Pd-Catalyzed Enolate Alkenylation by Solé, Daniel, Urbaneja, Xavier, Bonjoch, Josep

“…The ABC ring system of the natural product calyciphylline A has been synthesized. The key steps were a palladium-catalyzed intramolecular coupling of an…”
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Synthetic and DFT Studies Towards a Unified Approach to Phlegmarine Alkaloids: Aza-Michael Intramolecular Processes Leading to 5-Oxodecahydroquinolines by Bradshaw, Ben, Luque-Corredera, Carlos, Saborit, Gisela, Cativiela, Carlos, Dorel, Ruth, Bo, Carles, Bonjoch, Josep

“…A diastereoselective synthesis of cis‐5‐oxodecahydroquinolines is described in which three stereocenters are generated in a one‐pot reaction. The reaction…”
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Hydrogen Atom Transfer (HAT)-Triggered Iron-Catalyzed Intra- and Intermolecular Coupling of Alkenes with Hydrazones: Access to Complex Amines by Saladrigas, Mar, Loren, Guillem, Bonjoch, Josep, Bradshaw, Ben

“…A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C–C bond through a radical process is described. The…”
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Cu(I)-catalyzed atom transfer radical cyclization of trichloroacetamides tethered to electron-deficient, -neutral, and -rich alkenes: synthesis of polyfunctionalized 2-azabicyclo[3.3.1]nonanes by Diaba, Faïza, Martínez-Laporta, Agustín, Bonjoch, Josep, Pereira, Ana, Muñoz-Molina, José María, Pérez, Pedro J, Belderrain, Tomás R

“…A novel synthetic entry to 2-azabicyclo[3.3.1]nonanes based on a copper(I)-catalyzed intramolecular coupling of amino-tethered trichloroacetamides and…”
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Polycyclic framework synthesis of anominine and tubingensin A indole diterpenoids by Bradshaw, Ben, Etxebarria-Jardí, Gorka, Bonjoch, Josep

“…A highly congested decalin embodying an alpha-methylene ketone is synthesized in 11 steps from the Wieland-Miescher ketone and efficiently converted to the…”
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Synthesis of a-chlorolactams by cyanoborohydride-mediated radical cyclization of trichloroacetamides by Coussanes, Guilhem, Jakobi, Harald, Lindell, Stephen, Bonjoch i Sesé, Josep

“…A cyanoborohydride-promoted radical cyclization methodology has been developed to access α-chlorolactams in a simple and efficient way, using NaBH3CN and…”
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Radical Cyclization of Alkene‐Tethered Ketones Initiated by Hydrogen‐Atom Transfer by Saladrigas, Mar, Bosch, Caroline, Saborit, Gisela V., Bonjoch, Josep, Bradshaw, Ben

“…An unprecedented C−C coupling reaction between alkenes and ketones by hydrogen‐atom transfer, using Fe(acac)3 and PhSiH3 in EtOH, is described. This mild…”
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Synthetic studies about strychnopivotine: synthesis of the bridged azatricyclic fragment by Solé, Daniel, Urbaneja, Xavier, Cordero-Vargas, Alejandro, Bonjoch, Josep

“…Pd(0)-promoted coupling of an amino-tethered vinyl iodide and ketone enolate is the key step to synthesize the CDE ring system of the indole alkaloid…”
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Synthesis of Diazatricyclic Core of Madangamines from cis-Perhydroisoquinolines by Quirante, Josefina, Paloma, Laura, Diaba, Faïza, Vila, Xavier, Bonjoch, Josep

“…Synthesis of the tricyclic core of madangamine alkaloids has been achieved in a 10-step sequence starting from a 4-(aminomethyl)anisole derivative. A Birch…”
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