Search Results - "Bonizzi, Arianna"
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Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy
Published in International journal of molecular sciences (13-03-2019)“…Cancer-associated fibroblasts (CAF) are the most abundant cells of the tumor stroma and they critically influence cancer growth through control of the…”
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Indocyanine Green Nanoparticles: Are They Compelling for Cancer Treatment?
Published in Frontiers in chemistry (16-07-2020)“…Indocyanine green (ICG) is a Food and Drug Administration–approved near-infrared fluorescent dye, employed as an imaging agent for different clinical…”
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Tumor Accumulation and Off-Target Biodistribution of an Indocyanine-Green Fluorescent Nanotracer: An Ex Vivo Study on an Orthotopic Murine Model of Breast Cancer
Published in International journal of molecular sciences (05-02-2021)“…Indocyanine green (ICG) is a near infrared fluorescent tracer used in image-guided surgery to assist surgeons during resection. Despite appearing as a very…”
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HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity
Published in Biomedicines (25-06-2021)“…High-density lipoproteins (HDLs) represent a class of lipoproteins very heterogeneous in structure, composition, and biological functions, which carry out…”
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Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
Published in Pharmaceutics (25-11-2021)“…Protein nanocages have been studied extensively, due to their unique architecture, exceptional biocompatibility and highly customization capabilities. In…”
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Ferritin nanoconjugates guide trastuzumab brain delivery to promote an antitumor response in murine HER2 + breast cancer brain metastasis
Published in Pharmacological research (01-10-2023)“…Brain metastasis (BM) represents a clinical challenge for patients with advanced HER2 + breast cancer (BC). The monoclonal anti-HER2 antibody trastuzumab (TZ)…”
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Development and validation of a simple and versatile method for the quantification of everolimus loaded in H-ferritin nanocages using UHPLC-MS/MS
Published in Journal of pharmaceutical and biomedical analysis (30-11-2020)“…•The method was developed to quantify Everolimus in nanocages of H-Ferritin.•HEverolimus is a new naturally occurring delivery system.•Ultra High Performance…”
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Bisdemethoxycurcumin (BDC)-Loaded H-Ferritin-Nanocages Mediate the Regulation of Inflammation in Alzheimer’s Disease Patients
Published in International journal of molecular sciences (17-08-2022)“…Background: Bisdemethoxycurcumin (BDC) might be an inflammation inhibitor in Alzheimer’s Disease (AD). However, BDC is almost insoluble in water, poorly…”
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Ultrastructural analysis of breast cancer patient-derived organoids
Published in Cancer cell international (10-08-2021)“…Abstract Background Breast cancer Patient Derived Organoids (PDO) have been demonstrated to be a reliable model to study cancer that promised to replace and…”
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Impact of doxorubicin-loaded ferritin nanocages (FerOX) vs. free doxorubicin on T lymphocytes: a translational clinical study on breast cancer patients undergoing neoadjuvant chemotherapy
Published in Journal of nanobiotechnology (15-04-2024)“…Despite the advent of numerous targeted therapies in clinical practice, anthracyclines, including doxorubicin (DOX), continue to play a pivotal role in breast…”
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Combined Method to Remove Endotoxins from Protein Nanocages for Drug Delivery Applications: The Case of Human Ferritin
Published in Pharmaceutics (06-02-2021)“…Protein nanocages represent an emerging candidate among nanoscaled delivery systems. Indeed, they display unique features that proved to be very interesting…”
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Selective Targeting of Cancer-Associated Fibroblasts by Engineered H-Ferritin Nanocages Loaded with Navitoclax
Published in Cells (Basel, Switzerland) (05-02-2021)“…Cancer-associated fibroblasts (CAFs) are key actors in regulating cancer progression. They promote tumor growth, metastasis formation, and induce drug…”
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Development of Tumor-Targeted Indocyanine Green-Loaded Ferritin Nanoparticles for Intraoperative Detection of Cancers
Published in ACS omega (02-06-2020)“…Indocyanine green (ICG) is a fluorescent dye with a strong emission in the near-infrared spectral range that allows deep signal penetration and minimal…”
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Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution
Published in Cancer cell international (27-06-2024)“…A reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diagnosed with breast cancer (BC) to…”
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Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson's Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects
Published in Stem cells translational medicine (01-09-2015)“…Homing of intraarterially infused rat mesenchymal stem cells (rMSCs) in the brain of rats bearing a 6‐hydroxydopamine (6‐OHDA)‐induced lesion of the…”
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Deciphering the Role of H‑Ferritin Nanocages in Improving Tumor-Targeted Delivery of Indocyanine Green: Combined Analysis of Murine Tissue Homogenates with UHPLC–MS/MS and Fluorescence
Published in ACS omega (26-12-2023)“…We investigated the relevance of encapsulation in H-ferritin nanocages (HFn) in determining an improved tumor-targeted delivery of indocyanine green (ICG)…”
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Everolimus Nanoformulation in Biological Nanoparticles Increases Drug Responsiveness in Resistant and Low-Responsive Breast Cancer Cell Lines
Published in Pharmaceutics (02-08-2019)“…Everolimus (Eve) is an FDA approved drug that inhibits mammalian target of rapamycin (mTOR). It is employed in breast cancer treatment even if its…”
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Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy
Published in Applied sciences (01-11-2021)“…Background: Bariatric surgery (BS) is an important procedure used for the treatment of morbid obesity and has been proven to improve, or even cure, type 2…”
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Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Published in Cancer research (Chicago, Ill.) (15-04-2021)“…Emerging evidence indicates that gut microbiota affect the response to anticancer therapies by modulating the host immune system. In this study, we…”
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