Search Results - "Bonilla, Weldy V"

Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function by Balmer, Maria L., Ma, Eric H., Bantug, Glenn R., Grählert, Jasmin, Pfister, Simona, Glatter, Timo, Jauch, Annaïse, Dimeloe, Sarah, Slack, Emma, Dehio, Philippe, Krzyzaniak, Magdalena A., King, Carolyn G., Burgener, Anne-Valérie, Fischer, Marco, Develioglu, Leyla, Belle, Réka, Recher, Mike, Bonilla, Weldy V., Macpherson, Andrew J., Hapfelmeier, Siegfried, Jones, Russell G., Hess, Christoph

“…How systemic metabolic alterations during acute infections impact immune cell function remains poorly understood. We found that acetate accumulates in the…”
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T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses by Baumann, Claudia, Bonilla, Weldy V., Fröhlich, Anja, Helmstetter, Caroline, Peine, Michael, Hegazy, Ahmed N., Pinschewer, Daniel D., Löhning, Max

“…Significance The alarmin IL-33 amplifies immune responses of Th2 and CD8 ⁺ cytotoxic T cells against invading pathogens; however, little is known about a…”
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Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy by Kallert, Sandra M., Darbre, Stephanie, Bonilla, Weldy V., Kreutzfeldt, Mario, Page, Nicolas, Müller, Philipp, Kreuzaler, Matthias, Lu, Min, Favre, Stéphanie, Kreppel, Florian, Löhning, Max, Luther, Sanjiv A., Zippelius, Alfred, Merkler, Doron, Pinschewer, Daniel D.

“…Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL eff ) responses. Conversely, the induction of protective…”
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Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment by Ring, Sandra S., Cupovic, Jovana, Onder, Lucas, Lütge, Mechthild, Perez-Shibayama, Christian, Gil-Cruz, Cristina, Scandella, Elke, De Martin, Angelina, Mörbe, Urs, Hartmann, Fabienne, Wenger, Robert, Spiegl, Matthias, Besse, Andrej, Bonilla, Weldy V., Stemeseder, Felix, Schmidt, Sarah, Orlinger, Klaus K., Krebs, Philippe, Ludewig, Burkhard, Flatz, Lukas

“…The tumor microenvironment (TME) is a complex amalgam of tumor cells, immune cells, endothelial cells and fibroblastic stromal cells (FSC). Cancer-associated…”
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Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer by Schmidt, Sarah, Bonilla, Weldy V., Reiter, Andrea, Stemeseder, Felix, Kleissner, Theresa, Oeler, Daniel, Berka, Ursula, El-Gazzar, Ahmed, Kiefmann, Bettina, Schulha, Sophie C., Raguz, Josipa, Habbeddine, Mohamed, Scheinost, Marilies, Qing, Xiaoping, Lauterbach, Henning, Matushansky, Igor, Pinschewer, Daniel D., Orlinger, Klaus K.

“…Infection with human papillomavirus (HPV) is associated with a variety of cancer types and limited therapy options. Therapeutic cancer vaccines targeting the…”
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Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming by Bénéchet, Alexandre P., De Simone, Giorgia, Di Lucia, Pietro, Cilenti, Francesco, Barbiera, Giulia, Le Bert, Nina, Fumagalli, Valeria, Lusito, Eleonora, Moalli, Federica, Bianchessi, Valentina, Andreata, Francesco, Zordan, Paola, Bono, Elisa, Giustini, Leonardo, Bonilla, Weldy V., Bleriot, Camille, Kunasegaran, Kamini, Gonzalez-Aseguinolaza, Gloria, Pinschewer, Daniel D., Kennedy, Patrick T. F., Naldini, Luigi, Kuka, Mirela, Ginhoux, Florent, Cantore, Alessio, Bertoletti, Antonio, Ostuni, Renato, Guidotti, Luca G., Iannacone, Matteo

“…The responses of CD8 + T cells to hepatotropic viruses such as hepatitis B range from dysfunction to differentiation into effector cells, but the mechanisms…”
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The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses by Bonilla, Weldy V, Fröhlich, Anja, Senn, Karin, Kallert, Sandra, Fernandez, Marylise, Johnson, Susan, Kreutzfeldt, Mario, Hegazy, Ahmed N, Schrick, Christina, Fallon, Padraic G, Klemenz, Roman, Nakae, Susumu, Adler, Heiko, Merkler, Doron, Löhning, Max, Pinschewer, Daniel D

“…Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also…”
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The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection by Marx, Anna-Friederike, Kallert, Sandra M., Brunner, Tobias M., Villegas, José A., Geier, Florian, Fixemer, Jonas, Abreu-Mota, Tiago, Reuther, Peter, Bonilla, Weldy V., Fadejeva, Jelizaveta, Kreutzfeldt, Mario, Wagner, Ingrid, Aparicio-Domingo, Patricia, Scarpellino, Leo, Charmoy, Mélanie, Utzschneider, Daniel T., Hagedorn, Claudia, Lu, Min, Cornille, Karen, Stauffer, Karsten, Kreppel, Florian, Merkler, Doron, Zehn, Dietmar, Held, Werner, Luther, Sanjiv A., Löhning, Max, Pinschewer, Daniel D.

“…T cell factor 1 (Tcf-1) expressing CD8+ T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection…”
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Effects of Promyelocytic Leukemia Protein on Virus-Host Balance by Bonilla, Weldy V, Pinschewer, Daniel D, Klenerman, Paul, Rousson, Valentin, Gaboli, Mirella, Pandolfi, Pier P, Zinkernagel, Rolf M, Salvato, Maria S, Hengartner, Hans

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss by Kreutzfeldt, Mario, Bergthaler, Andreas, Fernandez, Marylise, Brück, Wolfgang, Steinbach, Karin, Vorm, Mariann, Coras, Roland, Blümcke, Ingmar, Bonilla, Weldy V, Fleige, Anne, Forman, Ruth, Müller, Werner, Becher, Burkhard, Misgeld, Thomas, Kerschensteiner, Martin, Pinschewer, Daniel D, Merkler, Doron

“…Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have…”
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Protective efficacy of individual CD8+ T cell specificities in chronic viral infection by Johnson, Susan, Bergthaler, Andreas, Graw, Frederik, Flatz, Lukas, Bonilla, Weldy V, Siegrist, Claire-Anne, Lambert, Paul-Henri, Regoes, Roland R, Pinschewer, Daniel D

“…Specific CD8(+) T cells (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in humans and lymphocytic choriomeningitis…”
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Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack by Bonilla, Weldy V., Kirchhammer, Nicole, Marx, Anna-Friederike, Kallert, Sandra M., Krzyzaniak, Magdalena A., Lu, Min, Darbre, Stéphanie, Schmidt, Sarah, Raguz, Josipa, Berka, Ursula, Vincenti, Ilena, Pauzuolis, Mindaugas, Kerber, Romy, Hoepner, Sabine, Günther, Stephan, Magnus, Carsten, Merkler, Doron, Orlinger, Klaus K., Zippelius, Alfred, Pinschewer, Daniel D.

“…Therapeutic vaccination regimens inducing clinically effective tumor-specific CD8+ T lymphocyte (CTL) responses are an unmet medical need. We engineer two…”
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Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire by Bonilla, Weldy V, Geuking, Markus B, Aichele, Peter, Ludewig, Burkhard, Hengartner, Hans, Zinkernagel, Rolf M

“…Rare cases of stable allograft acceptance after discontinuation of immunosuppression are often accompanied by macrochimerism (> 1% donor cells in blood) or…”
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Arenavirus-based vector platform for massive tumor self-antigen-specific CD8 T cell immunity by Orlinger, Klaus Karl, Bonilla, Weldy V., Kallert, Sandra M, Kirchhammer, Nicole, Marx, Anna-Friederike, Krzyzaniak, Magdalena, Schmidt, Sarah, Raguz, Josipa, Berka, Ursula, Guenther, Stephan, Zippelius, Alfred, Pinschewer, Daniel

“…Abstract only e14297 Background: The induction of powerful CD8+ T cell immunity to tumor associated self-antigens (TAAs) represents a critical yet challenging…”
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Arenavirus vectors for massive tumor self-antigen-specific CD8 T cell attack by Pinschewer, Daniel D., Bonilla, Weldy V., Kallert, Sandra, Kirchhammer, Nicole, Marx, Anna-Friederike, Krzyzaniak, Magdalena, Schmidt, Sarah, Raguz, Josipa, Berka, Ursula, Günther, Stephan, Magnus, Carsten, Orlinger, Klaus, Zippelius, Alfred

“…Abstract Therapeutic vaccination regimens inducing high frequencies of clinically effective tumor-targeting CD8 T cells represent an unmet need in cancer…”
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Live-attenuated LCMV-based vector for active immunotherapy of HPV16+ cancer by Schmidt, Sarah, Bonilla, Weldy V., Pauzuolis, Mindaugas, Reiter, Andrea, Kleissner, Theresa, Oeler, Daniel, Stemeseder, Felix, Berka, Ursula, Kiefmann, Bettina, Schulha, Sophie, Matushansky, Igor, Merkler, Doron, Pinschewer, Daniel, Orlinger, Klaus Karl

“…Abstract only e14303 Background: Active immunization against cancer requires the induction of exquisitely potent tumor-specific CD8 + T cell (CTL) responses,…”
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Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss by Kreutzfeldt, Mario, Bergthaler, Andreas, Fernandez, Marylise, Brück, Wolfgang, Steinbach, Karin, Vorm, Mariann, Coras, Roland, Blümcke, Ingmar, Bonilla, Weldy V., Fleige, Anne, Forman, Ruth, Müller, Werner, Becher, Burkhard, Misgeld, Thomas, Kerschensteiner, Martin, Pinschewer, Daniel D., Merkler, Doron

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The Alarmin lnterleukin-33 Drives Protective Antiviral CD8⁺ T Cell Responses by Bonilla, Weldy V., Fröhlich, Anja, Senn, Karin, Kallert, Sandra, Fernandez, Marylise, Johnson, Susan, Kreutzfeldt, Mario, Hegazy, Ahmed N., Schrick, Christina, Fallon, Padraic G., Klemenz, Roman, Nakae, Susumu, Adler, Heiko, Merkler, Doron, Löhning, Max, Pinschewer, Daniel D.

“…Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also…”
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The Alarmin lnterieukin-33 Drives Protective Antiviral CD8+T Cell Responses by BONILLA, Weldy V, FRÖHLICH, Anja, KLEMENZ, Roman, NAKAE, Susumu, ADLER, Heiko, MERKLER, Doron, LÖHNING, Max, PINSCHEWER, Daniel D, SENN, Karin, KALLERT, Sandra, FERNANDEZ, Marylise, JOHNSON, Susan, KREUTZFELDT, Mario, HEGAZY, Ahmed N, SCHRICK, Christina, FALLON, Padraic G

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Perforin‐independent regulation of dendritic cell homeostasis by CD8+ T cells in vivo: implications for adaptive immunotherapy by Ludewig, Burkhard, Bonilla, Weldy V., Dumrese, Tilman, Odermatt, Bernhard, Zinkernagel, Rolf M., Hengartner, Hans

“…We investigated here the effects of perforin on CTL responses during interaction of dendritic cells (DC) with cytotoxic T lymphocytes in vivo. Using MHC class…”
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