Search Results - "Bonilla, Leo"

Absolute Quantification of the G Protein-Coupled Receptor Rhodopsin by LC/MS/MS Using Proteolysis Product Peptides and Synthetic Peptide Standards by Barnidge, David R, Dratz, Edward A, Martin, Therese, Bonilla, Leo E, Moran, Liam B, Lindall, Arnold

“…Methods for the absolute quantification of a membrane protein are described using isotopically labeled or unlabeled synthetic peptides as standards. Synthetic…”
Get full text

24-Hour Lock Mass Protection by Lee, Kimberly A, Farnsworth, Chris, Yu, Wen, Bonilla, Leo E

“…The positive role and application of highly accurate mass measurements in proteomics is well documented. The new generation of hybrid FTMS and Q-TOF…”
Get full text

Maximizing the sensitivity and reliability of peptide identification in large-scale proteomic experiments by harnessing multiple search engines by Yu, Wen, Taylor, J. Alex, Davis, Michael T, Bonilla, Leo E, Lee, Kimberly A, Auger, Paul L, Farnsworth, Chris C, Welcher, Andrew A, Patterson, Scott D

“…Despite recent advances in qualitative proteomics, the automatic identification of peptides with optimal sensitivity and accuracy remains a difficult goal. To…”
Get full text

Free and total biotherapeutic evaluation in chromatographic assays: interference from targets and immunogenicity by White, Joleen T, Bonilla, Leo E

“…Measurement of drug concentrations is critical during drug development, supporting evaluation of safety and efficacy in the context of pharmacokinetics…”
Get more information

The evolution of tools for protein phosphorylation site analysis: from discovery to clinical application by Bonilla, Leo, Means, Gary, Lee, Kimberly, Patterson, Scott

“…The importance of the analysis of signaling pathways has been proven for many years by the elucidation of key signaling molecules. However, in most cases these…”
Get full text

Proteoform: a single term describing protein complexity by Smith, Lloyd M, Kelleher, Neil L

Get full text

Quantitation of 4-Oxo-4-(3-pyridyl)butanoic Acid and Enantiomers of 4-Hydroxy-4-(3-pyridyl)butanoic Acid in Human Urine:  A Substantial Pathway of Nicotine Metabolism by Hecht, Stephen S, Hatsukami, Dorothy K, Bonilla, Leo E, Hochalter, J. Bradley

“…A liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS/MS) method was developed to analyze human urine for…”
Get full text

Intra-specific variability of feverfew: correlations between parthenolide, morphological traits and seed origin by Cutlan, A R, Bonilla, L E, Simon, J E, Erwin, J E

“…Parthenolide, a biologically active sesquiterpene lactone found in feverfew [Tanacetum parthenium (L.) Schultz Bip., Asteraceae], has been indirectly linked to…”
Get more information

Systems toxicology by Hartung, Thomas, van Vliet, Erwin, Jaworska, Joanna, Bonilla, Leo, Skinner, Nigel, Thomas, Russell

“…The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess…”
Get full text

Lactols in Hydrolysates of DNA Treated with α-Acetoxy-N-nitrosopyrrolidine or Crotonaldehyde by Wang, Mingyao, Upadhyaya, Pramod, Dinh, Trieu T, Bonilla, Leo E, Hecht, Stephen S

“…α-Acetoxy-N-nitrosopyrrolidine (α-acetoxyNPYR) is a stable precursor to α-hydroxyNPYR, the initial product of metabolism and proposed proximate carcinogen of…”
Get full text

Eosinophil Peroxidase Oxidation of Thiocyanate by Arlandson, Mary, Decker, Troy, Roongta, Vikram A., Bonilla, Leo, Mayo, Kevin H., MacPherson, Jennifer C., Hazen, Stanley L., Slungaard, Arne

“…Although the pseudohalide thiocyanate (SCN−) is the preferred substrate for eosinophil peroxidase (EPO) in fluids of physiologic halide composition, the…”
Get full text

Heme from Alzheimer's brain inhibits muscarinic receptor binding via thiyl radical generation by Venters, Homer D, Bonilla, Leo E, Jensen, Tara, Garner, Hart P, Bordayo, Elizabeth Z, Najarian, Melissa M, Ala, Thomas A, Mason, Ronald P, Frey, William H

“…An endogenous inhibitor (<3500 Da) of antagonist binding to the muscarinic acetylcholine receptor (mAChR) has been reported to be elevated 3-fold in…”
Get full text

A study of glycoproteins in human serum and plasma reference standards (HUPO) using multilectin affinity chromatography coupled with RPLC-MS/MS by Yang, Ziping, Hancock, William S., Chew, Tori Richmond, Bonilla, Leo

“…The glycoproteome is a major subproteome present in human plasma. In this study, we isolated and characterized approximately 150 glycoproteins from the human…”
Get full text

Eosinophil peroxidase oxidation of thiocyanate. Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system by Arlandson, M, Decker, T, Roongta, V A, Bonilla, L, Mayo, K H, MacPherson, J C, Hazen, S L, Slungaard, A

“…Although the pseudohalide thiocyanate (SCN(-)) is the preferred substrate for eosinophil peroxidase (EPO) in fluids of physiologic halide composition, the…”
Get full text

Maximizing the sensitivity and reliability of peptide identification in large-scale proteomic experiments by harnessing multiple search engines: Proteomics Data Management by WEN YU, TAYLOR, J. Alex, DAVIS, Michael T, BONILLA, Leo E, LEE, Kimberly A, AUGER, Paul L, FARNSWORTH, Chris C, WELCHER, Andrew A, PATTERSON, Scott D

Get full text

A study of glycoproteins in human serum and plasma reference standards (HUPO) using multilectin affinity chromatography coupled with RPLC-MS/MS: Exploring the Human Plasma Proteome: The HUPO Plasma Proteome Project (HPPP) by ZIPING YANG, HANCOCK, William S, CHEW, Tori Richmond, BONILLA, Leo

Get full text

Performance characteristics of an FT MS-based workflow for label-free differential MS analysis of human plasma: standards, reproducibility, targeted feature investigation, and application to a model of controlled myocardial infarction by Sutton, Jennifer, Richmond, Tori, Shi, Xu, Athanas, Michael, Ptak, Celeste, Gerszten, Robert, Bonilla, Leo

“…Proteomics is undergoing a rapid transformation from a qualitative global peptide sequencing discipline into a quantitative, reproducibility‐driven practice…”
Get full text

Performance characteristics of an FT MS-based workflow for label-free differential MS analysis of human plasma : standards, reproducibility, targeted feature investigation, and application to a model of controlled myocardial infarction : Cardiovascular proteomics by SUTTON, Jennifer, RICHMOND, Tori, XU SHI, ATHANAS, Michael, PTAK, Celeste, GERSZTEN, Robert, BONILLA, Leo

Get full text

A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke by Parsons, W D, Carmella, S G, Akerkar, S, Bonilla, L E, Hecht, S S

“…We analyzed the urine of nonsmoking hospital workers exposed to environmental tobacco smoke for…”
Get full text

Heme from Alzheimer's brain inhibits muscarinic receptor binding via thiyl radical generation1An abstract of some of these findings was published in Mol. Biol. Cell, 7:S (1996) #3765.1 by Venters, Homer D, Bonilla, Leo E, Jensen, Tara, Garner, Hart P, Bordayo, Elizabeth Z, Najarian, Melissa M, Ala, Thomas A, Mason, Ronald P, Frey, William H

Get full text