Determinants of antithrombin consumption in cardiac operations requiring cardiopulmonary bypass

Determinants of antithrombin consumption in cardiac operations requiring cardiopulmonary bypass

Antithrombin (AT) is a natural anticoagulant that is consumed during cardiac operations with cardiopulmonary bypass (CPB). This study is an observational trial aimed at identifying the factors determining the magnitude of the AT consumption during cardiac operations. Two hundred and fifty consecutiv...

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Bibliographic Details
Published in:Perfusion Vol. 19; no. 1; pp. 47 - 52
Main Authors: Ranucci, Marco, Ditta, Antonio, Boncilli, Alessandra, Cotza, Mauro, Carboni, Giovanni, Brozzi, Simonetta, Bonifazi, Claudio, Tiezzi, Alessandra
Format: Journal Article
Language:English
Published: Thousand Oaks, CA SAGE Publications 01-01-2004
Sage Publications Ltd
Subjects:
Aged
Aging - metabolism
Antithrombin III - metabolism
Body Temperature
Cardiac Surgical Procedures
Cardiopulmonary Bypass
Diabetes Complications
Diabetes Mellitus - drug therapy
Female
Heart Diseases - complications
Heart Diseases - metabolism
Heart Diseases - surgery
Hematocrit
Humans
Male
Middle Aged
Models, Theoretical
Postoperative Period
Preoperative Care
Prospective Studies
Time Factors
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Summary:Antithrombin (AT) is a natural anticoagulant that is consumed during cardiac operations with cardiopulmonary bypass (CPB). This study is an observational trial aimed at identifying the factors determining the magnitude of the AT consumption during cardiac operations. Two hundred and fifty consecutive adult patients undergoing cardiac operations with CPB were admitted to the study. Preoperative and intraoperative variables were tested with respect to their role in determining AT activity at the end of the operation. At a univariate analysis, eight predictors of AT activity at the end of the operation have been identified: preoperative AT activity; age; diabetes on medication; preoperative haematocrit value; preoperative dialysis; combined operation; CPB duration; lowest temperature on CPB. A multivariate predictive model was created, and five factors remained as independent predictors of AT activity at the end of the operation: preoperative AT activity (p = 0.001); age (p = 0.015); combined operation (p = 0.014); diabetes (p = 0.013) and CPB duration (p = 0.001). On this basis, predictive tables of AT consumption have been established for different combinations of risk factors.
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ISSN:0267-6591
1477-111X
DOI:10.1191/0267659104pf711oa