Search Results - "Bonifacio, Maria Joao"

Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys by Bonifácio, Maria João, Sousa, Filipa, Soares-da-Silva, Patrício

“…Opicapone is a third generation nitrocatechol catechol-O-methyltransferase inhibitor that has received regional market approval for use as adjunctive therapy…”
Get full text

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide by Hebeisen, Simon, Pires, Nuno, Loureiro, Ana I., Bonifácio, Maria João, Palma, Nuno, Whyment, Andrew, Spanswick, David, Soares-da-Silva, Patrício

“…This study aimed at evaluating the effects of eslicarbazepine, carbamazepine (CBZ), oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated…”
Get full text

Metabolism and disposition of zamicastat in rats by Araújo, Francisca, Dória, Maria Luisa, Beliaev, Alexandre, Kiss, László E, Bonifácio, Maria João, Holenz, Joerg, Soares-da-Silva, Patrício, Loureiro, Ana Isabel

“…The metabolism and disposition of zamicastat, a reversible dopamine β-hydroxylase (DβH) inhibitor, developed for treatment of Pulmonary Arterial Hypertension…”
Get full text

Absorption, metabolism and excretion of opicapone in human healthy volunteers by Loureiro, Ana I., Rocha, Francisco, Santos, Ana T., Singh, Nand, Bonifácio, Maria João, Pinto, Rui, Kiss, Laszlo E., Soares‐da‐Silva, Patrício

“…Aims The absorption, metabolism and excretion of opicapone (2,5‐dichloro‐3‐(5‐[3,4‐dihydroxy‐5‐nitrophenyl]‐1,2,4‐oxadiazol‐3‐yl)‐4,6‐dimethylpyridine…”
Get full text

Organ-Specific Overexpression of Renal LAT2 and Enhanced Tubular l-DOPA Uptake Precede the Onset of Hypertension by Pinho, Maria João, Gomes, Pedro, Serrão, Maria Paula, Bonifácio, Maria João, Soares-da-Silva, Patrício

“…ABSTRACT—Spontaneously hypertensive rats (SHR) might have increased renal production of dopamine. l-3,4-Dihydroxyphenylalanine (l-DOPA) uptake in renal…”
Get full text

Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration by Kitajima, Takashi, Mizote, Shintaro, Bonifácio, Maria João, Umemura, Takeo, Yoneda, Kazuhiro, Moser, Paul, Soares-da-Silva, Patrício, Tanaka, Makoto

“…The aim of the study was to clarify the dose response for inhibition of catechol-O-methyltransferase (COMT) by opicapone, a third generation COMT inhibitor,…”
Get full text

Opicapone: a short lived and very long acting novel catechol‐O‐methyltransferase inhibitor following multiple dose administration in healthy subjects by Rocha, José Francisco, Almeida, Luis, Falcão, Amílcar, Palma, P. Nuno, Loureiro, Ana I., Pinto, Roberto, Bonifácio, Maria João, Wright, Lyndon C., Nunes, Teresa, Soares‐da‐Silva, Patrício

“…Aims The aim of this study was to assess the tolerability, pharmacokinetics and inhibitory effect on erythrocyte soluble catechol‐O‐methyltransferase (S‐COMT)…”
Get full text

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat by Gonçalves, Daniela, Alves, Gilberto, Fortuna, Ana, Bonifácio, Maria João, Soares-da-Silva, Patrício, Falcão, Amílcar

“…Opicapone is a novel catechol-O-methyltransferase (COMT) inhibitor that emerged to fulfil the need of a safer and more efficacious COMT inhibitor. The present…”
Get full text

Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects: Prediction of Slow Enzyme–Inhibitor Complex Dissociation of a Short-Living and Very Long-Acting Inhibitor by Almeida, Luis, Rocha, José Francisco, Falcão, Amílcar, Nuno Palma, P., Loureiro, Ana I., Pinto, Roberto, Bonifácio, Maria João, Wright, Lyndon C., Nunes, Teresa, Soares-da-Silva, Patrício

“…Background and Objectives Opicapone is a novel catechol- O -methyltransferase (COMT) inhibitor. The purpose of this study was to evaluate the tolerability,…”
Get full text

Effect of opicapone multiple‐dose regimens on levodopa pharmacokinetics by Rocha, José‐Francisco, Sicard, Éric, Fauchoux, Nicolas, Falcão, Amílcar, Santos, Ana, Loureiro, Ana I., Pinto, Roberto, Bonifácio, Maria João, Nunes, Teresa, Almeida, Luís, Soares‐da‐Silva, Patrício

“…Aims To compare the levodopa/carbidopa (LC) and levodopa/benserazide (LB) pharmacokinetic profiles following repeated doses of opicapone (OPC) administered…”
Get full text

Carbamazepine aggravates absence seizures in two dedicated mouse models by Pires, Nuno Marques, Bonifácio, Maria João, Soares-da-Silva, Patrício

“…The aim of this study was to evaluate the effect of carbamazepine (CBZ) upon chemically induced absence seizures and in a genetic absence seizures model in the…”
Get more information

N-acetylation of etamicastat, a reversible dopamine-β-hydroxylase inhibitor by Loureiro, Ana I, Fernandes-Lopes, Carlos, Bonifácio, Maria João, Wright, Lyndon C, Soares-da-Silva, Patrício

“…Etamicastat [(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride] is a reversible dopamine-β-hydroxylase inhibitor that…”
Get full text

Characterization of the interaction of the novel antihypertensive etamicastat with human dopamine-β-hydroxylase: Comparison with nepicastat by Bonifácio, Maria João, Sousa, Filipa, Neves, Marco, Palma, Nuno, Igreja, Bruno, Pires, Nuno Miguel, Wright, Lyndon C., Soares-da-Silva, Patrício

“…The interaction of etamicastat, a novel peripherally acting dopamine-β-hydroxylase (DBH) inhibitor, with the enzyme was studied using a classical kinetic…”
Get full text

Performance of hydrophobic interaction ligands for human membrane-bound catechol-O-methyltransferase purification by Santos, Fátima Milhano, Pedro, Augusto Quaresma, Soares, Rui Filipe, Martins, Rita, Bonifácio, Maria João, Queiroz, João António, Passarinha, Luís António

“…Despite of membrane catechol‐O‐methyltransferase (MBCOMT, EC 2.1.1.6) physiological importance on catecholamines’ O‐methylation, no studies allowed their total…”
Get full text

Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone by Bonifácio, Maria João, Loureiro, Ana I., Torrão, Leonel, Fernandes-Lopes, Carlos, Wright, Lyndon, Pinho, Maria João, Soares-da-Silva, Patrício

“…The present study was designed to characterize pharmacodynamic and pharmacokinetic properties of nebicapone in rats and mice. Upon oral administration of…”
Get full text

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10‐2474 by Bonifácio, Maria‐João, Sousa, Filipa, Aires, Cátia, Loureiro, Ana I., Fernandes‐Lopes, Carlos, Pires, Nuno M., Palma, Pedro Nuno, Moser, Paul, Soares‐da‐Silva, Patrício

“…Background and Purpose In 2016, one person died and four others had mild‐to‐severe neurological symptoms during a phase I trial of the fatty acid amide…”
Get full text

Synthesis and Biological Evaluation of a Novel Series of “Ortho-Nitrated” Inhibitors of Catechol-O-methyltransferase by Learmonth, David A, Bonifácio, Maria João, Soares-da-Silva, Patrício

“…Novel regioisomeric “ortho-nitrated” catechols related to the catechol-O-methyltransferase (COMT) inhibitors BIA 3-202 3 and BIA 3-335 4 were synthesized and…”
Get full text

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug by Doeser, Anna, Dickhof, Gesa, Reitze, Margit, Uebachs, Mischa, Schaub, Christina, Pires, Nuno Miguel, Bonifácio, Maria João, Soares-da-Silva, Patrício, Beck, Heinz

“…In human epilepsy, pharmacoresistance to antiepileptic drug therapy is a major problem affecting a substantial fraction of patients. Many of the currently…”
Get full text

Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase by Kiss, László E, Ferreira, Humberto S, Torrão, Leonel, Bonifácio, Maria João, Palma, P. Nuno, Soares-da-Silva, Patrício, Learmonth, David A

“…Novel nitrocatechol-substituted heterocycles were designed and evaluated for their ability to inhibit catechol-O-methyltransferase (COMT). Replacement of the…”
Get full text

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol- O-methyltransferase inhibitor by Bonifácio, Maria João, Vieira-Coelho, Maria Augusta, Soares-da-Silva, Patrı́cio

“…The present study reports the kinetic inhibitory profile of 1-[3,4-dihydroxy-5-nitrophenyl]-2-phenyl-ethanone (BIA 3-202), a novel inhibitor of soluble…”
Get full text