Search Results - "Bonierbale, E"

Drug-induced immunotoxicity by Dansette, P M, Bonierbale, E, Minoletti, C, Beaune, P H, Pessayre, D, Mansuy, D

“…Immune-related drug responses are one of the most common sources of idiosyncratic toxicity. A number of organs may be the target of such reactions; however,…”
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Opposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two Compounds by Bonierbale, Eric, Valadon, Philippe, Pons, Catherine, Desfosses, Bernard, Dansette, Patrick M, Mansuy, Daniel

“…Tienilic acid (TA) is responsible for an immune-mediated drug-induced hepatitis in humans, while its isomer (TAI) triggers a direct hepatitis in rats. In this…”
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Specificity of in vitro Covalent Binding of Tienilic Acid Metabolites to Human Liver Microsomes in Relationship to the Type of Hepatotoxicity: Comparison with Two Directly Hepatotoxic Drugs by Lecoeur, Sylvaine, Bonierbale, Eric, Challine, Dominique, Gautier, Jean-Charles, Valadon, Philippe, Dansette, Patrick M, Catinot, Rachel, Ballet, Francois, Mansuy, Daniel, Beaune, Philippe H

“…In order to better understand the first steps leading to drug-induced immunoallergic hepatitis, we studied the target of anti-LKM2 autoantibodies appearing in…”
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Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera by Robin, M A, Maratrat, M, Le Roy, M, Le Breton, F P, Bonierbale, E, Dansette, P, Ballet, F, Mansuy, D, Pessayre, D

“…Patients with tienilic acid hepatitis exhibit autoantibodies that recognize unalkylated cytochrome P450 2C9 in humans but recognize 2C11 in rats. Our aim was…”
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Application of capillary gas chromatography to the study of hydrolysis of the nerve agent VX in rat plasma by Bonierbale, Eric, Debordes, Lydia, Coppet, Lucien

“…We present here a gas chromatography technique allowing the detection and quantification of VX [ O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate] a…”
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