Search Results - "Bonham, Andrew"
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Development of an Electrochemical, DNA‐Based Biosensor to the Cancer Biomarker ENOX2
Published in The FASEB journal (01-05-2022)“…One challenge to the identification of cancerous malignancies is the ability to detect cancer‐specific antigens in a rapid, reliable, and accessible manner…”
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An Electrochemical Biosensor for Detection of P.69 Pertactin Associated with B. pertussis
Published in The FASEB journal (01-05-2022)“…Whooping cough caused by Bordetella pertussis can cause serious and prolonged health effects and is especially deadly in infants. Early treatment can…”
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Electrochemical DNA Biosensor to Detect Glycopeptidolipids of Nontuberculous Mycobacteria
Published in The FASEB journal (01-05-2022)“…In many regions, nontuberculous Mycobacteria (NTM) pulmonary infections have outnumbered tuberculosis infections over the past 30 years, yet NTM infections are…”
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CheapStat: an open-source, "do-it-yourself" potentiostat for analytical and educational applications
Published in PloS one (13-09-2011)“…Although potentiostats are the foundation of modern electrochemical research, they have seen relatively little application in resource poor settings, such as…”
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Pyllelic, a Software Suite for Examining Allelic DNA CpG Methylation Patterns in Genomic Datasets
Published in The FASEB journal (01-05-2022)“…While genome‐wide demethylation of DNA CpG sites is a well‐established early hallmark of cancer, only recently has the presence of allelic methylation patterns…”
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Real-time, aptamer-based tracking of circulating therapeutic agents in living animals
Published in Science translational medicine (27-11-2013)“…A sensor capable of continuously measuring specific molecules in the bloodstream in vivo would give clinicians a valuable window into patients' health and…”
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Electrochemical Aptamer-Based Biosensor for Detecting Pap31, a Biomarker for Carrion’s Disease
Published in Sensors (Basel, Switzerland) (15-11-2024)“…Carrion’s disease, caused by infection with the bacterium Bartonella bacilliformis (B. bacilliformis), is effectively treated with antibiotics, but reaches…”
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Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers
Published in Molecular oncology (01-10-2020)“…In cancer, active expression of the TERT gene paradoxically correlates with a hypermethylated CpG island. Here, we show that in 833 cancer cell lines…”
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9
Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications
Published in ACS applied materials & interfaces (22-05-2019)“…Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the heart following myocardial infarction, which is associated with…”
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Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
Published in Nature communications (26-07-2019)“…The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver…”
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Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins
Published in Chemical communications (Cambridge, England) (01-10-2015)“…Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for…”
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Electrochemical DNA Biosensor That Detects Early Celiac Disease Autoantibodies
Published in Sensors (Basel, Switzerland) (10-04-2021)“…Although it is estimated that more than one million Americans have celiac disease (CD), it remains challenging to diagnose. CD, an autoimmune and inflammatory…”
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13
A paucity of knowledge regarding nontuberculous mycobacterial lipids compared to the tubercle bacillus
Published in Tuberculosis (Edinburgh, Scotland) (01-03-2019)“…All mycobacteria, including nontuberculous mycobacteria (NTM), synthesize an array of lipids including phosphatidylinositol mannosides (PIM), lipomannan (LM),…”
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14
Detection of Sequence-Specific Protein-DNA Interactions via Surface Enhanced Resonance Raman Scattering
Published in Journal of the American Chemical Society (28-11-2007)“…We developed a new strategy to detect protein-DNA binding through surface enhanced resonance Raman scattering (SERRS). Silver-plated DNA and gold nanoparticle…”
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Quantification of Transcription Factor Binding in Cell Extracts Using an Electrochemical, Structure-Switching Biosensor
Published in Journal of the American Chemical Society (22-02-2012)“…Transcription factor expression levels, which sensitively reflect cellular development and disease state, are typically monitored via cumbersome,…”
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Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin
Published in Stem cells and development (01-08-2010)“…Human induced pluripotent stem cells (iPSCs) hold promise as a source of adult-derived, patient-specific pluripotent cells for use in cell-based regenerative…”
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Transcription Factor Beacons for the Quantitative Detection of DNA Binding Activity
Published in Journal of the American Chemical Society (07-09-2011)“…The development of convenient, real-time probes for monitoring protein function in biological samples represents an important challenge of the postgenomic era…”
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Rapid and Quantitative Detection of Lung Cancer Biomarker ENOX2 Using a Novel Aptamer in an Electrochemical DNA-Based (E-DNA) Biosensor
Published in Biosensors (Basel) (25-06-2023)“…To overcome early cancer detection challenges, diagnostic tools enabling more sensitive, rapid, and noninvasive detection are necessary. An attractive cancer…”
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Global and regional long‐term survival following resection for HCC in the recent decade: A meta‐analysis of 110 studies
Published in Hepatology communications (01-07-2022)“…Surgical resection for HCC remains a major curative treatment option, but it is unclear whether there are differences in outcomes by region and whether…”
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Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor
Published in Analyst (London) (07-10-2013)“…We describe an electrochemical analog of fluorescence polarization that supports the quantitative measurement of a specific protein, the chemokine IP-10,…”
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