Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension

Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension

Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactiv...

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Published in:International journal of hypertension Vol. 2020; no. 2020; pp. 1 - 13
Main Authors: Bonfim Vieira, Aline, Alves, Luciana Lontro, da Silva, Jemima F. R., de Carvalho, Jorge J., Araújo, Victor H. V. de O., Salata, Camila, Moraes, Alan C. N., Andrade, Cherley B. V., Rabelo, Kíssila, Pereira, Priscila G., do Nascimento, Ana L. R., de Matos, Veronica S., Ciambarella, Bianca Torres
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 21-10-2020
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Adrenal glands
Aldosterone
Animals
Antibodies
Apoptosis
Autophagy
Blood pressure
Corticosteroids
Electrolytes
Ethylenediaminetetraacetic acid
Hormones
Hypertension
Kidney diseases
Laboratories
Microscopy
Oxidative stress
Plasma
Proteins
Veins & arteries
Brazil
United States > US
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Summary:Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a renin inhibiting drug that suppresses RAAS and culminates in decreased renin release, plasma angiotensin II concentration, and inhibition of aldosterone secretion. In this sense, the aim of the present study was to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone, after treatment with aliskiren in Wistar rats with 2K1C hypertension. Parameters as structure and ultrastructure of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression were analyzed by immunostaining and electron microscopy. Our results showed that the hypertensive animals treated with aliskiren presented a reestablishment of AT1 receptor expression and decrease in apoptosis and autophagy. In addition, treatment with aliskiren improves the cell aspects in the adrenal glomerular zone, evidenced by ultrastructural analysis through preserved nuclei and well-developed mitochondria. Therefore, our evidence suggests that aliskiren has a beneficial effect on the adrenal glomerular zone remodeling in animals with renovascular hypertension.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Tomohiro Katsuya
ISSN:2090-0384
2090-0392
2090-0392
DOI:10.1155/2020/7684849