Search Results - "Bonetto, Valentina"

Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis by Ferrara, Deborah, Pasetto, Laura, Bonetto, Valentina, Basso, Manuela

“…Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults and primarily targets upper and lower motor neurons. The progression of…”
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Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers by Zucchi, Elisabetta, Bonetto, Valentina, Sorarù, Gianni, Martinelli, Ilaria, Parchi, Piero, Liguori, Rocco, Mandrioli, Jessica

“…Abstract Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases. The pathobiology of motor neuron degeneration is still largely…”
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Neural stem cell-derived extracellular vesicles: mini players with key roles in neurogenesis, immunomodulation, neuroprotection and aging by Bonetto, Valentina, Grilli, Mariagrazia

“…Neural stem/progenitor cells (NSPCs) are self-renewing and multipotent cells of the central nervous system where they give rise to neurons, astrocytes and…”
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Sunitinib-mediated inhibition of STAT3 in skeletal muscle and spinal cord does not affect the disease in a mouse model of ALS by Tortarolo, Massimo, Re Cecconi, Andrea David, Camporeale, Laura, Margotta, Cassandra, Nardo, Giovanni, Pasetto, Laura, Bonetto, Valentina, Galbiati, Mariarita, Crippa, Valeria, Poletti, Angelo, Piccirillo, Rosanna, Bendotti, Caterina

“…Variability in disease onset and progression is a hallmark of amyotrophic lateral sclerosis (ALS), both in sporadic and genetic forms. Recently, we found that…”
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The importance of gravity vector on adult mammalian organisms: Effects of hypergravity on mouse testis by Bonetto, Valentina, Magnelli, Valeria, Sabbatini, Maurizio, Caprì, Flavia, van Loon, Jack J. W. A, Tavella, Sara, Masini, Maria Angela

“…In the age of space exploration, the effect of hypergravity on human physiology is a relatively neglected topic. However, astronauts have several experiences…”
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New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models by Nardo, Giovanni, Trolese, Maria Chiara, Tortarolo, Massimo, Vallarola, Antonio, Freschi, Mattia, Pasetto, Laura, Bonetto, Valentina, Bendotti, Caterina

“…Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous disease in terms of progression rate and survival. This is probably one of the reasons for the failure…”
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Microgravity as a Tool to Investigate Cancer Induction in Pleura Mesothelial Cells by Bonetto, Valentina, Pagano, Corinna Anais, Sabbatini, Maurizio, Magnelli, Valeria, Donadelli, Massimo, Marengo, Emilio, Masini, Maria Angela

“…The present work shows that the exposure of mesothelial cells to simulated microgravity changes their cytoskeleton and adhesion proteins, leading to a cell…”
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Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice by Fabbrizio, Paola, D’Agostino, Jessica, Margotta, Cassandra, Mella, Giulia, Panini, Nicolò, Pasetto, Laura, Sammali, Eliana, Raggi, Flavia, Sorarù, Gianni, Bonetto, Valentina, Bendotti, Caterina, Nardo, Giovanni

“…Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder that leads to progressive degeneration of motor neurons and severe muscle atrophy without…”
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Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis by Luotti, Silvia, Pasetto, Laura, Porcu, Luca, Torri, Valter, Elezgarai, Saioa R., Pantalone, Serena, Filareti, Melania, Corbo, Massimo, Lunetta, Christian, Mora, Gabriele, Bonetto, Valentina

“…Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which there are no validated biomarkers. Previous exploratory studies have identified a…”
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Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations by Bonetto, Valentina, Pasetto, Laura, Lisi, Ilaria, Carbonara, Marco, Zangari, Rosalia, Ferrari, Erica, Punzi, Veronica, Luotti, Silvia, Bottino, Nicola, Biagianti, Bruno, Moglia, Cristina, Fuda, Giuseppe, Gualtierotti, Roberta, Blasi, Francesco, Canetta, Ciro, Montano, Nicola, Tettamanti, Mauro, Camera, Giorgia, Grimoldi, Maria, Negro, Giulia, Rifino, Nicola, Calvo, Andrea, Brambilla, Paolo, Biroli, Francesco, Bandera, Alessandra, Nobili, Alessandro, Stocchetti, Nino, Sessa, Maria, Zanier, Elisa R

“…Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is associated with disorders affecting the peripheral and the central nervous system. A high…”
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Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury by Mercurio, Domenico, Pischiutta, Francesca, Seminara, Serena, Tribuzio, Francesca, Lisi, Ilaria, Pasetto, Laura, Bonetto, Valentina, De Simoni, Maria-Grazia, Schwaeble, Wilhelm, Yaseen, Sadam, Dudler, Thomas, Zanier, Elisa R, Fumagalli, Stefano

“…The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue damage and loss of function following traumatic brain injury (TBI). LP…”
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Redox proteomics: Identification of oxidatively modified proteins by Ghezzi, Pietro, Bonetto, Valentina

“…Reactive oxygen and nitrogen species may cause various types of chemical modifications on specific proteins, Such modifications if irreversible are often…”
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Micro-computed tomography for non-invasive evaluation of muscle atrophy in mouse models of disease by Pasetto, Laura, Olivari, Davide, Nardo, Giovanni, Trolese, Maria Chiara, Bendotti, Caterina, Piccirillo, Rosanna, Bonetto, Valentina

“…Muscle wasting occurs during various chronic diseases and precedes death in humans as in mice. The evaluation of the degree of muscle atrophy in diseased mouse…”
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Cyclophillin A deficiency accelerates RML-induced prion disease by Bouybayoune, Ihssane, Comerio, Liliana, Pasetto, Laura, Bertani, Ilaria, Bonetto, Valentina, Chiesa, Roberto

“…Prion diseases typically involve brain deposition of abnormally folded prion protein, which is associated with activated glia and increased cytokine…”
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Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target by Caldi Gomes, Lucas, Hänzelmann, Sonja, Hausmann, Fabian, Khatri, Robin, Oller, Sergio, Parvaz, Mojan, Tzeplaeff, Laura, Pasetto, Laura, Gebelin, Marie, Ebbing, Melanie, Holzapfel, Constantin, Columbro, Stefano Fabrizio, Scozzari, Serena, Knöferle, Johanna, Cordts, Isabell, Demleitner, Antonia F., Deschauer, Marcus, Dufke, Claudia, Sturm, Marc, Zhou, Qihui, Zelina, Pavol, Sudria-Lopez, Emma, Haack, Tobias B., Streb, Sebastian, Kuzma-Kozakiewicz, Magdalena, Edbauer, Dieter, Pasterkamp, R. Jeroen, Laczko, Endre, Rehrauer, Hubert, Schlapbach, Ralph, Carapito, Christine, Bonetto, Valentina, Bonn, Stefan, Lingor, Paul

“…Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a…”
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RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue by Vallarola, Antonio, Sironi, Francesca, Tortarolo, Massimo, Gatto, Noemi, De Gioia, Roberta, Pasetto, Laura, De Paola, Massimiliano, Mariani, Alessandro, Ghosh, Supurna, Watson, Richard, Kalmes, Andreas, Bonetto, Valentina, Bendotti, Caterina

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects the motor neuromuscular system leading to complete paralysis and…”
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Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells by Nardo, Giovanni, Pozzi, Silvia, Pignataro, Mauro, Lauranzano, Eliana, Spano, Giorgia, Garbelli, Silvia, Mantovani, Stefania, Marinou, Kalliopi, Papetti, Laura, Monteforte, Marta, Torri, Valter, Paris, Luca, Bazzoni, Gianfranco, Lunetta, Christian, Corbo, Massimo, Mora, Gabriele, Bendotti, Caterina, Bonetto, Valentina

“…Amyotrophic lateral sclerosis (ALS) is a fatal progressive motor neuron disease, for which there are still no diagnostic/prognostic test and therapy. Specific…”
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Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis by Pasetto, Laura, Pozzi, Silvia, Castelnovo, Mariachiara, Basso, Manuela, Estevez, Alvaro G, Fumagalli, Stefano, De Simoni, Maria Grazia, Castellaneta, Valeria, Bigini, Paolo, Restelli, Elena, Chiesa, Roberto, Trojsi, Francesca, Monsurrò, Maria Rosaria, Callea, Leonardo, Malešević, Miroslav, Fischer, Gunter, Freschi, Mattia, Tortarolo, Massimo, Bendotti, Caterina, Bonetto, Valentina

“…Neuroinflammation is a major hallmark of amyotrophic lateral sclerosis (ALS), which is currently untreatable. Several anti-inflammatory compounds have been…”
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Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis by Pasetto, Laura, Callegaro, Stefano, Corbelli, Alessandro, Fiordaliso, Fabio, Ferrara, Deborah, Brunelli, Laura, Sestito, Giovanna, Pastorelli, Roberta, Bianchi, Elisa, Cretich, Marina, Chiari, Marcella, Potrich, Cristina, Moglia, Cristina, Corbo, Massimo, Sorarù, Gianni, Lunetta, Christian, Calvo, Andrea, Chiò, Adriano, Mora, Gabriele, Pennuto, Maria, Quattrone, Alessandro, Rinaldi, Francesco, D'Agostino, Vito Giuseppe, Basso, Manuela, Bonetto, Valentina

“…Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron disease for which currently there is no effective treatment. There is an…”
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A Novel HGF/SF Receptor (MET) Agonist Transiently Delays the Disease Progression in an Amyotrophic Lateral Sclerosis Mouse Model by Promoting Neuronal Survival and Dampening the Immune Dysregulation by Vallarola, Antonio, Tortarolo, Massimo, De Gioia, Roberta, Iamele, Luisa, de Jonge, Hugo, de Nola, Giovanni, Bovio, Enrica, Pasetto, Laura, Bonetto, Valentina, Freschi, Mattia, Bendotti, Caterina, Gherardi, Ermanno

“…Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease with no effective treatment. The Hepatocyte Growth Factor/Scatter Factor (HGF/SF),…”
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