Search Results - "Boneski, Paige K"

Systematic Functional Analysis of PINK1 and PRKN Coding Variants by Broadway, Benjamin J., Boneski, Paige K., Bredenberg, Jenny M., Kolicheski, Ana, Hou, Xu, Soto-Beasley, Alexandra I., Ross, Owen A., Springer, Wolfdieter, Fiesel, Fabienne C.

“…Loss of either PINK1 or PRKN causes an early onset Parkinson’s disease (PD) phenotype. Functionally, PINK1 and PRKN work together to mediate stress-activated…”
Get full text

Abcc6 Null Mice-a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging by Boneski, Paige K, Madhu, Vedavathi, Tomlinson, Ryan E, Shapiro, Irving M, van de Wetering, Koen, Risbud, Makarand V

“…Chronic low back pain is a highly prevalent health condition intricately linked to intervertebral disc degeneration. One of the prominent features of disc…”
Get full text

Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W by Bustillos, Bernardo A, Cocker, Liam T, Coban, Mathew A, Weber, Caleb A, Bredenberg, Jenny M, Boneski, Paige K, Siuda, Joanna, Slawek, Jaroslaw, Puschmann, Andreas, Narendra, Derek P, Graff-Radford, Neill R, Wszolek, Zbigniew K, Dickson, Dennis W, Ross, Owen A, Caulfield, Thomas R, Springer, Wolfdieter, Fiesel, Fabienne C

“…Mutations in the and genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most…”
Get full text

Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF‐1α–BNIP3 Axis by Madhu, Vedavathi, Boneski, Paige K, Silagi, Elizabeth, Qiu, Yunping, Kurland, Irwin, Guntur, Anyonya R, Shapiro, Irving M, Risbud, Makarand V

“…ABSTRACT Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of the intervertebral disc and are predominantly glycolytic due to…”
Get full text

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc by Madhu, Vedavathi, Hernandez-Meadows, Miriam, Boneski, Paige K, Qiu, Yunping, Guntur, Anyonya R, Kurland, Irwin J., Barve, Ruteja A, Risbud, Makarand V.

“…The contribution of mitochondria to the metabolic function of hypoxic NP cells has been overlooked. We have shown that NP cells contain networked mitochondria…”
Get full text

Substitution of PINK1 Gly411 modulates substrate receptivity and turnover by Fiesel, Fabienne C, Fričová, Dominika, Hayes, Caleb S, Coban, Mathew A, Hudec, Roman, Bredenberg, Jenny M, Broadway, Benjamin J, Markham, Briana N, Yan, Tingxiang, Boneski, Paige K, Fiorino, Gabriella, Watzlawik, Jens O, Hou, Xu, McCarty, Arthur M, Lewis-Tuffin, Laura J, Zhong, Jun, Madden, Benjamin J, Ordureau, Alban, An, Heeseon, Puschmann, Andreas, Wszolek, Zbigniew K, Ross, Owen A, Harper, J Wade, Caulfield, Thomas R, Springer, Wolfdieter

“…The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils…”
Get full text

Systematic Functional Analysis of IPINK1/I and IPRKN/I Coding Variants by Broadway, Benjamin J, Boneski, Paige K, Bredenberg, Jenny M, Kolicheski, Ana, Hou, Xu, Soto-Beasley, Alexandra I, Ross, Owen A, Springer, Wolfdieter, Fiesel, Fabienne C

“…Loss of either PINK1 or PRKN causes an early onset Parkinson’s disease (PD) phenotype. Functionally, PINK1 and PRKN work together to mediate stress-activated…”
Get full text