Search Results - "Bonelli, Michael"

Treg cells in autoimmunity: from identification to Treg-based therapies by Göschl, Lisa, Scheinecker, Clemens, Bonelli, Michael

“…Regulatory (Treg) cells are key regulators of inflammation and important for immune tolerance and homeostasis. A major progress has been made in the…”
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How does abatacept really work in rheumatoid arthritis? by Bonelli, Michael, Scheinecker, Clemens

“…PURPOSE OF REVIEWThe purpose of this review is to summarize the current knowledge concerning the mechanisms of action of Abatacept in patients with rheumatoid…”
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Translational and clinical advances in JAK‐STAT biology: The present and future of jakinibs by Gadina, Massimo, Johnson, Catrina, Schwartz, Daniella, Bonelli, Michael, Hasni, Sarfaraz, Kanno, Yuka, Changelian, Paul, Laurence, Arian, O'Shea, John J.

“…In this era, it is axiomatic that cytokines have critical roles in cellular development and differentiation, immune homeostasis, and host defense. Equally,…”
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Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis by Dema, Barbara, Pellefigues, Christophe, Hasni, Sarfaraz, Gault, Nathalie, Jiang, Chao, Ricks, Tiffany K, Bonelli, Michael M, Scheffel, Jörg, Sacré, Karim, Jablonski, Mathieu, Gobert, Delphine, Papo, Thomas, Daugas, Eric, Illei, Gabor, Charles, Nicolas, Rivera, Juan

“…The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and…”
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Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases by Schwartz, Daniella M., Bonelli, Michael, Gadina, Massimo, O'Shea, John J.

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Essential role of microRNA‐155 in the pathogenesis of autoimmune arthritis in mice by Blüml, Stephan, Bonelli, Michael, Niederreiter, Birgit, Puchner, Antonia, Mayr, Georg, Hayer, Silvia, Koenders, Marije I., van den Berg, Wim B., Smolen, Josef, Redlich, Kurt

“…Objective MicroRNAs (miRNA) are a new class of regulatory elements. Altered expression of miRNA has been demonstrated in the inflamed joints of patients with…”
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Advanced immunophenotyping: A powerful tool for immune profiling, drug screening, and a personalized treatment approach by Preglej, Teresa, Brinkmann, Marie, Steiner, Günter, Aletaha, Daniel, Göschl, Lisa, Bonelli, Michael

“…Various autoimmune diseases are characterized by distinct cell subset distributions and activation profiles of peripheral blood mononuclear cells (PBMCs)…”
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Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity by Hirahara, Kiyoshi, Onodera, Atsushi, Villarino, Alejandro V., Bonelli, Michael, Sciumè, Giuseppe, Laurence, Arian, Sun, Hong-Wei, Brooks, Stephen R., Vahedi, Golnaz, Shih, Han-Yu, Gutierrez-Cruz, Gustavo, Iwata, Shigeru, Suzuki, Ryo, Mikami, Yohei, Okamoto, Yoshitaka, Nakayama, Toshinori, Holland, Steven M., Hunter, Christopher A., Kanno, Yuka, O’Shea, John J.

“…Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique…”
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Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE) by Bonelli, Michael, Savitskaya, Anastasia, von Dalwigk, Karolina, Steiner, Carl Walter, Aletaha, Daniel, Smolen, Josef S., Scheinecker, Clemens

“…The objective of the study was that the regulatory T cells (Treg) that specialize in the suppression of immune responses might be critically involved in the…”
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IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes by Bonelli, Michael, Dalwigk, Karolina, Platzer, Alexander, Isabel Olmos Calvo, Hayer, Silvia, Niederreiter, Birgit, Holinka, Johannes, Sevelda, Florian, Pap, Thomas, Steiner, Günter, Superti-Furga, Giulio, Smolen, Josef S, Kiener, Hans P, Karonitsch, Thomas

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by persistent synovial inflammation. The major drivers of synovial inflammation are cytokines…”
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Strain-specific properties and T cells regulate the susceptibility to papilloma induction by Mus musculus papillomavirus 1 by Handisurya, Alessandra, Day, Patricia M, Thompson, Cynthia D, Bonelli, Michael, Lowy, Douglas R, Schiller, John T

“…The immunocytes that regulate papillomavirus infection and lesion development in humans and animals remain largely undefined. We found that immunocompetent…”
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Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions by Villarino, Alejandro, Laurence, Arian, Robinson, Gertraud W, Bonelli, Michael, Dema, Barbara, Afzali, Behdad, Shih, Han-Yu, Sun, Hong-Wei, Brooks, Stephen R, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J

“…The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the…”
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Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiency by Göschl, Lisa, Mrak, Daniel, Grabmeier-Pfistershammer, Katharina, Stiasny, Karin, Haslacher, Helmuth, Schneider, Lisa, Deimel, Thomas, Kartnig, Felix, Tobudic, Selma, Aletaha, Daniel, Burgmann, Heinz, Bonelli, Michael, Pickl, Winfried F., Förster-Waldl, Elisabeth, Scheinecker, Clemens, Vossen, Matthias Gerhard

“…Background Patients with inborn errors of immunity (IEI) are at increased risk for severe courses of SARS-CoV-2 infection. COVID-19 vaccination provides…”
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MicroRNA-155 Controls T Helper Cell Activation During Viral Infection by Goncalves-Alves, Eliana, Saferding, Victoria, Schliehe, Christopher, Benson, Robert, Kurowska-Stolarska, Mariola, Brunner, Julia Stefanie, Puchner, Antonia, Podesser, Bruno K, Smolen, Josef S, Redlich, Kurt, Bonelli, Michael, Brewer, James, Bergthaler, Andreas, Steiner, Günter, Blüml, Stephan

“…MicroRNA (miR) 155 has been implicated in the regulation of innate and adaptive immunity as well as autoimmune processes. Importantly, it has been shown to…”
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Deficiency of Cathelicidin-related Antimicrobial Peptide Promotes Skin Papillomatosis in Mus musculus Papillomavirus 1-infected Mice by Dorfer, Sonja, Strasser, Katharina, Reipert, Siegfried, Fischer, Michael B, Shafti-Keramat, Saeed, Bonelli, Michael, Schröckenfuchs, Georg, Bauer, Wolfgang, Kancz, Stefanie, Müller, Lena, Handisurya, Alessandra

“…Cathelicidins have been reported to inhibit human papillomavirus infection in vitro; however, nothing is known about their activity in vivo. In this study,…”
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Factors in Free Fasciocutaneous Flap Complications: A Logistic Regression Analysis by Reece, Edward M., Bonelli, Michael A., Livingston, Tyler, Mulligan, Paul S., Rockwood, Johnathan, Wilson, Jeffrey R., Zoldos, Jozef, Champagne, Lloyd

“…Free tissue transfer using fasciocutaneous flaps has increased in frequency over the past decade. Predictive analyses are lacking for fasciocutaneous free…”
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Small extracellular vesicles are released ex vivo from platelets into serum and from residual blood cells into stored plasma by Małys, Małgorzata S., Köller, Maximilian C., Papp, Kristin, Aigner, Christof, Dioso, Daffodil, Mucher, Patrick, Schachner, Helga, Bonelli, Michael, Haslacher, Helmuth, Rees, Andrew J., Kain, Renate

“…Small extracellular vesicles (sEV) purified from blood have great potential clinically as biomarkers for systemic disease; however interpretation is…”
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Regulatory T cells form stable and long-lasting cell cluster with myeloid dendritic cells (DC) by Herman, Sonja, Krenbek, Dagmar, Klimas, Michael, Bonelli, Michael, Steiner, Carl W, Pietschmann, Peter, Smolen, Josef S, Scheinecker, Clemens

“…Regulatory T cells (Treg) with the capacity to suppress T-cell proliferation exert various effects on T cell function. In addition, Treg have been shown to…”
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A dynamic real time in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model by Byrne, Ruth, Rath, Eva, Hladik, Anastasiya, Niederreiter, Birgit, Bonelli, Michael, Frantal, Sophie, Smolen, Josef S, Scheinecker, Clemens

“…Neutrophilic granulocytes and monocytes (granulomonocytic cells; GMC) drive the inflammatory process at the earliest stages of rheumatoid arthritis (RA). The…”
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P160 Drug survival in SLE: real world data from the vienna lupus cohort by Mrak, Daniel, Pacher, Julia, Reischmann, Lena, Weber, Peter, Kastrati, Kastriot, Heinz, Leonhard X, Aletaha, Daniel, Bonelli, Michael Markus, Lechner-Radner, Helga

“…ObjectiveThe heterogeneity of systemic lupus erythematosus (SLE) poses a challenge in clinical care. Several treatment options are available, but data on…”
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