Search Results - "Bonekamp, Nina"

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid by Kukat, Christian, Davies, Karen M., Wurm, Christian A., Spåhr, Henrik, Bonekamp, Nina A., Kühl, Inge, Joos, Friederike, Polosa, Paola Loguercio, Park, Chan Bae, Posse, Viktor, Falkenberg, Maria, Jakobs, Stefan, Kühlbrandt, Werner, Larsson, Nils-Göran

“…Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in…”
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SnapShot: Mitochondrial Nucleoid by Bonekamp, Nina A, Larsson, Nils-Göran

“…Mitochondrial DNA is compacted into nucleoprotein complexes denoted mitochondrial nucleoids, the focus of this SnapShot…”
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Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells by Costello, Joseph L, Castro, Inês G, Camões, Fátima, Schrader, Tina A, McNeall, Doug, Yang, Jing, Giannopoulou, Evdokia-Anastasia, Gomes, Sílvia, Pogenberg, Vivian, Bonekamp, Nina A, Ribeiro, Daniela, Wilmanns, Matthias, Jedd, Gregory, Islinger, Markus, Schrader, Michael

“…Tail-anchored (TA) proteins contain a single transmembrane domain (TMD) at the C-terminus that anchors them to the membranes of organelles where they mediate…”
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Reactive oxygen species and peroxisomes: Struggling for balance by Bonekamp, Nina A., Völkl, Alfred, Fahimi, H. Dariush, Schrader, Michael

“…Reactive oxygen species (ROS) can surely be considered as multifunctional biofactors within the cell. They are known to participate in regular cell functions,…”
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Small-molecule inhibitors of human mitochondrial DNA transcription by Bonekamp, Nina A., Peter, Bradley, Hillen, Hauke S., Felser, Andrea, Bergbrede, Tim, Choidas, Axel, Horn, Moritz, Unger, Anke, Di Lucrezia, Raffaella, Atanassov, Ilian, Li, Xinping, Koch, Uwe, Menninger, Sascha, Boros, Joanna, Habenberger, Peter, Giavalisco, Patrick, Cramer, Patrick, Denzel, Martin S., Nussbaumer, Peter, Klebl, Bert, Falkenberg, Maria, Gustafsson, Claes M., Larsson, Nils-Göran

“…Altered expression of mitochondrial DNA (mtDNA) occurs in ageing and a range of human pathologies (for example, inborn errors of metabolism, neurodegeneration…”
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Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen by Mennuni, Mara, Filograna, Roberta, Felser, Andrea, Bonekamp, Nina A, Giavalisco, Patrick, Lytovchenko, Oleksandr, Larsson, Nils‐Göran

“…Cancer cells depend on mitochondria to sustain their increased metabolic need and mitochondria therefore constitute possible targets for cancer treatment. We…”
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PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor by Schrader, Tina A, Carmichael, Ruth E, Islinger, Markus, Costello, Joseph L, Hacker, Christian, Bonekamp, Nina A, Weishaupt, Jochen H, Andersen, Peter M, Schrader, Michael

“…Peroxisome membrane dynamics and division are essential to adapt the peroxisomal compartment to cellular needs. The peroxisomal membrane protein PEX11β (also…”
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Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice by Kauppila, Johanna H K, Bonekamp, Nina A, Mourier, Arnaud, Isokallio, Marita A, Just, Alexandra, Kauppila, Timo E S, Stewart, James B, Larsson, Nils-Göran

“…Abstract Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA…”
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Cell lineage-specific mitochondrial resilience during mammalian organogenesis by Burr, Stephen P., Klimm, Florian, Glynos, Angelos, Prater, Malwina, Sendon, Pamella, Nash, Pavel, Powell, Christopher A., Simard, Marie-Lune, Bonekamp, Nina A., Charl, Julia, Diaz, Hector, Bozhilova, Lyuba V., Nie, Yu, Zhang, Haixin, Frison, Michele, Falkenberg, Maria, Jones, Nick, Minczuk, Michal, Stewart, James B., Chinnery, Patrick F.

“…Mitochondrial activity differs markedly between organs, but it is not known how and when this arises. Here we show that cell lineage-specific expression…”
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A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells by Koch, Annett, Yoon, Yisang, Bonekamp, Nina A, McNiven, Mark A, Schrader, Michael

“…The mammalian dynamin-like protein DLP1/Drp1 has been shown to mediate both mitochondrial and peroxisomal fission. In this study, we have examined whether…”
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6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells by Gomez-Lazaro, Maria, Bonekamp, Nina A., Galindo, Maria F., Jordán, Joaquin, Schrader, Michael

“…Mitochondrial alterations have been associated with the cytotoxic effect of 6-hydroxydopamine (6-OHDA), a widely used neurotoxin to study Parkinson's disease…”
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Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity by Sprenger, Hans-Georg, MacVicar, Thomas, Bahat, Amir, Fiedler, Kai Uwe, Hermans, Steffen, Ehrentraut, Denise, Ried, Katharina, Milenkovic, Dusanka, Bonekamp, Nina, Larsson, Nils-Göran, Nolte, Hendrik, Giavalisco, Patrick, Langer, Thomas

“…Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic. Here,…”
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High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo by Bonekamp, Nina A, Jiang, Min, Motori, Elisa, Garcia Villegas, Rodolfo, Koolmeister, Camilla, Atanassov, Ilian, Mesaros, Andrea, Park, Chan Bae, Larsson, Nils-Göran

“…Mitochondrial transcription factor A (TFAM) is compacting mitochondrial DNA (dmtDNA) into nucleoids and directly controls mtDNA copy number. Here, we show that…”
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Self-interaction of human Pex11pβ during peroxisomal growth and division by Bonekamp, Nina A, Grille, Sandra, Cardoso, Maria Joao, Almeida, Monica, Aroso, Miguel, Gomes, Silvia, Magalhaes, Ana Cristina, Ribeiro, Daniela, Islinger, Markus, Schrader, Michael

“…Pex11 proteins are involved in membrane elongation and division processes associated with the multiplication of peroxisomes. Human Pex11pβ has recently been…”
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POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA by Kühl, Inge, Miranda, Maria, Posse, Viktor, Milenkovic, Dusanka, Mourier, Arnaud, Siira, Stefan J, Bonekamp, Nina A, Neumann, Ulla, Filipovska, Aleksandra, Polosa, Paola Loguercio, Gustafsson, Claes M, Larsson, Nils-Göran

“…Mitochondria are vital in providing cellular energy via their oxidative phosphorylation system, which requires the coordinated expression of genes encoded by…”
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Analysis of the Mouse Hepatic Peroxisome Proteome-Identification of Novel Protein Constituents Using a Semi-Quantitative SWATH-MS Approach by Singin, Öznur, Astapenka, Artur, Costina, Victor, Kühl, Sandra, Bonekamp, Nina, Drews, Oliver, Islinger, Markus

“…Ongoing technical and bioinformatics improvements in mass spectrometry (MS) allow for the identifying and quantifying of the enrichment of increasingly…”
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Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane by Bonekamp, Nina A., Vormund, Kerstin, Jacob, Ralf, Schrader, Michael

“…The final step in the liberation of secretory vesicles from the trans-Golgi network (TGN) involves the mechanical action of the large GTPase dynamin as well as…”
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Transient Complex Interactions of Mammalian Peroxisomes Without Exchange of Matrix or Membrane Marker Proteins by Bonekamp, Nina A., Sampaio, Paula, Abreu, Fernão Vistulo, Lüers, Georg H., Schrader, Michael

“…Peroxisomes and mitochondria show a much closer interrelationship than previously anticipated. They co‐operate in the metabolism of fatty acids and reactive…”
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Transient complex peroxisomal interactions: A new facet of peroxisome dynamics in mammalian cells by Bonekamp, Nina A, Schrader, Michael

“…Mitochondria and peroxisomes are ubiquitous subcellular organelles that fulfill essential metabolic functions, rendering them indispensable for human…”
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Cytochemical detection of peroxisomes and mitochondria by Bonekamp, Nina A, Islinger, Markus, Lázaro, Maria Gómez, Schrader, Michael

“…Peroxisomes and mitochondria are essential subcellular organelles in mammals. Interestingly, recent studies have elucidated that these highly dynamic and…”
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