Search Results - "Bone Research"

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies by Guo, Qiang, Wang, Yuxiang, Xu, Dan, Nossent, Johannes, Pavlos, Nathan J, Xu, Jiake

“…Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive…”
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Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration by Wei, Hongpu, Cui, Jinjie, Lin, Kaili, Xie, Jing, Wang, Xudong

“…Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts are two main…”
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Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study by Zhang, Peixun, Li, Jia, Liu, Huixin, Han, Na, Ju, Jiabao, Kou, Yuhui, Chen, Lei, Jiang, Mengxi, Pan, Feng, Zheng, Yali, Gao, Zhancheng, Jiang, Baoguo

“…The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone…”
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Subchondral bone microenvironment in osteoarthritis and pain by Hu, Yan, Chen, Xiao, Wang, Sicheng, Jing, Yingying, Su, Jiacan

“…Osteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain, causing disability and economic burden…”
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Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy" by Masters, Elysia A, Trombetta, Ryan P, de Mesy Bentley, Karen L, Boyce, Brendan F, Gill, Ann Lindley, Gill, Steven R, Nishitani, Kohei, Ishikawa, Masahiro, Morita, Yugo, Ito, Hiromu, Bello-Irizarry, Sheila N, Ninomiya, Mark, Brodell, Jr, James D, Lee, Charles C, Hao, Stephanie P, Oh, Irvin, Xie, Chao, Awad, Hani A, Daiss, John L, Owen, John R, Kates, Stephen L, Schwarz, Edward M, Muthukrishnan, Gowrishankar

“…Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low,…”
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Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions by Lyu, Feng-Juan, Cui, Haowen, Pan, Hehai, Mc Cheung, Kenneth, Cao, Xu, Iatridis, James C, Zheng, Zhaomin

“…Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research…”
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Mechanical regulation of bone remodeling by Wang, Lijun, You, Xiuling, Zhang, Lingli, Zhang, Changqing, Zou, Weiguo

“…Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by…”
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Osteoarthritis: toward a comprehensive understanding of pathological mechanism by Chen, Di, Shen, Jie, Zhao, Weiwei, Wang, Tingyu, Han, Lin, Hamilton, John L, Im, Hee-Jeong

“…Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes…”
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Molecular mechanosensors in osteocytes by Qin Lei, Liu, Wen, Cao Huiling, Xiao Guozhi

“…Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of bone remodeling. In addition to their functions in endocrine…”
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Current understanding of osteoarthritis pathogenesis and relevant new approaches by Tong, Liping, Yu, Huan, Huang, Xingyun, Shen, Jie, Xiao, Guozhi, Chen, Lin, Wang, Huaiyu, Xing, Lianping, Chen, Di

“…Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular…”
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Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts by Han, Yujiao, You, Xiuling, Xing, Wenhui, Zhang, Zhong, Zou, Weiguo

“…The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells, namely osteoblasts, osteocytes, and osteoclasts exert…”
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Bone remodeling: an operational process ensuring survival and bone mechanical competence by Bolamperti, Simona, Villa, Isabella, Rubinacci, Alessandro

“…Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone…”
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Ankylosing spondylitis: etiology, pathogenesis, and treatments by Zhu, Wei, He, Xuxia, Cheng, Kaiyuan, Zhang, Linjie, Chen, Di, Wang, Xiao, Qiu, Guixing, Cao, Xu, Weng, Xisheng

“…Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing…”
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Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop by Chen, Fan, Jiang, Guowei, Liu, Hui, Li, Zemin, Pei, Yuxin, Wang, Hua, Pan, Hehai, Cui, Haowen, Long, Jun, Wang, Jianru, Zheng, Zhaomin

“…The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin (IL)-1β, and is one of the main causes of…”
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Exosomes: roles and therapeutic potential in osteoarthritis by Ni Zhenhong, Zhou Siru, Li, Song, Liang, Kuang, Chen Hangang, Luo Xiaoqing, Ouyang Junjie, He, Mei, Du Xiaolan, Chen, Lin

“…Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including…”
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Review of a new bone tumor therapy strategy based on bifunctional biomaterials by Liao, Jinfeng, Han, Ruxia, Wu, Yongzhi, Qian, Zhiyong

“…Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and…”
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On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook by Montoya, Carolina, Du, Yu, Gianforcaro, Anthony L, Orrego, Santiago, Yang, Maobin, Lelkes, Peter I

“…The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as the population ages…”
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Advanced smart biomaterials and constructs for hard tissue engineering and regeneration by Zhang, Ke, Wang, Suping, Zhou, Chenchen, Cheng, Lei, Gao, Xianling, Xie, Xianju, Sun, Jirun, Wang, Haohao, Weir, Michael D, Reynolds, Mark A, Zhang, Ning, Bai, Yuxing, Xu, Hockin H K

“…Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has…”
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TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation by Rahman, Md Shaifur, Akhtar, Naznin, Jamil, Hossen Mohammad, Banik, Rajat Suvra, Asaduzzaman, Sikder M

“…Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a fundamental role in the regulation of bone organogenesis through the…”
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Biomimetic delivery of signals for bone tissue engineering by Dang, Ming, Saunders, Laura, Niu, Xufeng, Fan, Yubo, Ma, Peter X

“…Bone tissue engineering is an exciting approach to directly repair bone defects or engineer bone tissue for transplantation. Biomaterials play a pivotal role…”
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