Search Results - "Bone Reports"

Bone fracture healing in mechanobiological modeling: A review of principles and methods by Ghiasi, Mohammad S, Chen, Jason, Vaziri, Ashkan, Rodriguez, Edward K, Nazarian, Ara

“…Bone fracture is a very common body injury. The healing process is physiologically complex, involving both biological and mechanical aspects. Following a…”
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A review of the latest insights into the mechanism of action of strontium in bone by Marx, Daniella, Rahimnejad Yazdi, Alireza, Papini, Marcello, Towler, Mark

“…Interest in strontium (Sr) has persisted over the last three decades due to its unique mechanism of action: it simultaneously promotes osteoblast function and…”
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Bisphosphonate conjugation for bone specific drug targeting by Farrell, Kristen B., Karpeisky, Alexander, Thamm, Douglas H., Zinnen, Shawn

“…Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders…”
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Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance by Dar, Hamid Y., Shukla, Prashant, Mishra, Pradyumna K., Anupam, Rajaneesh, Mondal, Rajesh K., Tomar, Geetanjali B., Sharma, Versha, Srivastava, Rupesh K.

“…Osteoporosis is one of the most important but often neglected bone disease associated with aging and postmenopausal condition leading to bone loss and…”
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Vitamin D in the Middle East and North Africa by Chakhtoura, Marlene, Rahme, Maya, Chamoun, Nariman, El-Hajj Fuleihan, Ghada

“…The Middle East and North Africa (MENA) region registers some of the lowest serum 25‑hydroxyvitamin D [25(OH)D] concentrations, worldwide. We describe the…”
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Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review by Bikle, Daniel D., Patzek, Sophie, Wang, Yongmei

“…Although the kidney was initially thought to be the sole organ responsible for the production of 1,25(OH)2D via the enzyme CYP27b1, it is now appreciated that…”
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Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target? by Surowiec, Rachel K., Allen, Matthew R., Wallace, Joseph M.

“…Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence mechanical properties and tissue quality. There is a growing…”
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The investigation of bone fracture healing under intramembranous and endochondral ossification by Ghimire, Smriti, Miramini, Saeed, Edwards, Glenn, Rotne, Randi, Xu, Jiake, Ebeling, Peter, Zhang, Lihai

“…After trauma, fractured bone starts healing directly through bone union or indirectly through callus formation process. Intramembranous and endochondral…”
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The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement by Marongiu, Giuseppe, Dolci, Andrea, Verona, Marco, Capone, Antonio

“…Diaphyseal fractures represent a complex biological entity that could often end into impaired bone-healing, with delayed union and non-union occurring up to…”
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Tumor-induced osteomalacia by Florenzano, Pablo, Gafni, Rachel I, Collins, Michael T

“…Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome clinically characterized by bone pain, fractures and muscle weakness. It is caused by…”
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An insight into the paradigms of osteoporosis: From genetics to biomechanics by Al Anouti, Fatme, Taha, Zainab, Shamim, Sadia, Khalaf, Kinda, Al Kaabi, Leena, Alsafar, Habiba

“…Considered as one of the major epidemics of the 21st century, osteoporosis affects approximately 200 million people globally, with significant worldwide impact…”
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The role of reactive oxygen species in bone cell physiology and pathophysiology by Marques-Carvalho, Adriana, Kim, Ha-Neui, Almeida, Maria

“…Hydrogen peroxide (H O ), superoxide anion radical (O •), and other forms of reactive oxygen species (ROS) are produced by the vast majority of mammalian cells…”
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The effect of osteoporosis and its treatment on fracture healing a systematic review of animal and clinical studies by Gorter, E.A., Reinders, C.R., Krijnen, P., Appelman-Dijkstra, N.M., Schipper, I.B.

“…Osteoporosis is characterised by low bone mass and micro-architectural deterioration of bone structure. Its treatment is directed at the processes of bone…”
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Calcium isotope ratios in blood and urine: A new biomarker for the diagnosis of osteoporosis by Eisenhauer, A, Müller, M, Heuser, A, Kolevica, A, Glüer, C-C, Both, M, Laue, C, Hehn, U V, Kloth, S, Shroff, R, Schrezenmeir, J

“…We assessed the potential of Calcium (Ca) isotope fractionation measurements in blood (δ Ca ) and urine (δ Ca ) as a new biomarker for the diagnosis of…”
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Post-traumatic osteoarthritis: A review of pathogenic mechanisms and novel targets for mitigation by Dilley, Julian E., Bello, Margaret Anne, Roman, Natoli, McKinley, Todd, Sankar, Uma

“…Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for 12 % of all osteoarthritis. These injuries, often of the lower…”
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Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling by Carriero, A., Pereira, A.F., Wilson, A.J., Castagno, S., Javaheri, B., Pitsillides, A.A., Marenzana, M., Shefelbine, S.J.

“…Bone is a dynamic tissue and adapts its architecture in response to biological and mechanical factors. Here we investigate how cortical bone formation is…”
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Amino acid metabolism in skeletal cells by Devignes, Claire-Sophie, Carmeliet, Geert, Stegen, Steve

“…Amino acid metabolism regulates essential cellular functions, not only by fueling protein synthesis, but also by supporting the biogenesis of nucleotides,…”
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Nutritional strategies to optimise musculoskeletal health for fall and fracture prevention: Looking beyond calcium, vitamin D and protein by Webster, James, Dalla Via, Jack, Langley, Christina, Smith, Cassandra, Sale, Craig, Sim, Marc

“…Falls and osteoporotic fractures are a major public health problem, particularly among older adults. A third of individuals aged 65 years and over fall at…”
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Cell energy metabolism and bone formation by Sautchuk, Rubens, Eliseev, Roman A.

“…Energy metabolism plays an important role in cell and tissue ability to effectively function, maintain homeostasis, and perform repair. Yet, the role of energy…”
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Real-world effects and adverse events of romosozumab in Japanese osteoporotic patients: A prospective cohort study by Kobayakawa, Tomonori, Suzuki, Takako, Nakano, Masaki, Saito, Makoto, Miyazaki, Akiko, Takahashi, Jun, Nakamura, Yukio

“…Real-world data on the new anti-sclerostin antibody drug, romosozumab, remain scarce. There is a strong need to accumulate and analyze data on romosozumab…”
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