Search Results - "Bone, A. J"

prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes by Richardson, S. J, Willcox, A, Bone, A. J, Foulis, A. K, Morgan, N. G

“…Aims/hypothesis Evidence that the beta cells of human patients with type 1 diabetes can be infected with enterovirus is accumulating, but it remains unclear…”
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Islet-associated macrophages in type 2 diabetes by Richardson, S. J, Willcox, A, Bone, A. J, Foulis, A. K, Morgan, N. G

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Analysis of islet inflammation in human type 1 diabetes by Willcox, A, Richardson, S.J, Bone, A.J, Foulis, A.K, Morgan, N.G

“…The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because of the limited availability of appropriate samples, but we now report…”
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Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1 by Richardson, S. J., Leete, P., Bone, A. J., Foulis, A. K., Morgan, N. G.

“…Aims/hypothesis Immunohistochemical staining reveals that the enteroviral capsid protein VP1 is present at higher frequency in the insulin-containing islets of…”
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Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes by Willcox, A, Richardson, S. J, Bone, A. J, Foulis, A. K, Morgan, N. G

“…Aims/hypothesis In adults, the rate of beta cell replication is normally very low, but recent evidence suggests that it may increase during insulitis. We…”
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Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes by Willcox, A., Richardson, S. J., Bone, A. J., Foulis, A. K., Morgan, N. G.

“…Aims/hypothesis The enteroviral capsid protein, VP1, was recently shown to be present in some beta cells in more than 60% of patients with recent-onset type 1…”
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Apoptosis and disease progression in the spontaneously diabetic BB/S rat by LALLY, F. J, RATCLIFF, H, BONE, A. J

“…Type I (insulin-dependent) diabetes mellitus is an autoimmune disease culminating in pancreatic beta-cell destruction. A role for apoptosis in this destruction…”
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Resistance to teratogenesis by F1 and F2 embryos of PAH-adapted Fundulus heteroclitus is strongly inherited despite reduced recalcitrance of the AHR pathway by Clark, Bryan W., Bone, A. J., Di Giulio, R. T.

“…Atlantic killifish ( Fundulus heteroclitus ) inhabiting the Atlantic Wood Superfund site on the Elizabeth River (Portsmouth, VA, USA) are exposed to a complex…”
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Tumor necrosis factor-α and interferon-γ inhibit insulin secretion and cause DNA damage in unweaned-rat islets : Extent of nitric oxide involvement by DUNGER, A, CUNNINGHAM, J. M, DELANEY, C. A, LOWE, J. E, GREEN, M. H. L, BONE, A. J, GREEN, I. C

“…Nitric oxide has been implicated as one possible mediator of interleukin-1 beta (IL-1)-induced inhibition of insulin secretion and islet cell damage. The aim…”
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Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Extent of nitric oxide involvement by Dunger, A., Cunningham, J. M., Delaney, C. A., Lowe, J. E., Green, M. H., Bone, A. J., Green, I. C.

“…Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Extent of nitric oxide involvement. A…”
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Insulitis and mechanisms of disease resistance : studies in an animal model of insulin dependent diabetes mellitus by BONE, A. J, HITCHCOCK, P. R, GWILLIAM, D. J, CUNNINGHAM, J. M, BARLEY, J

“…Insulin dependent diabetes mellitus (IDDM) is an autoimmune disease characterised by extreme insulin deficiency due to an overall decrease in the mass of…”
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Causal interpretation requires appropriate study design. Reply to Priest PC [letter] by Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K., Morgan, N. G.

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Distinct macrophage subpopulations in pancreas of prediabetic BB/E rats: possible role for macrophages in pathogenesis of IDDM by WALKER, R, BONE, A. J, COOKE, A, BAIRD, J. D

“…Use of monoclonal antibodies directed against rat macrophages and serial pancreatic biopsy in the prediabetic period have enabled us to document the…”
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Expression of an islet regenerating (reg) gene in isolated rat islets : effects of nutrient and non-nutrient growth factors by FRANCIS, P. J, SOUTHGATE, J. L, WILKIN, T. J, BONE, A. J

“…The expression of a novel regenerating (reg) gene has been reported previously in the regenerating islets of a surgical model of diabetes in rats. We exposed…”
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Distinct macrophage subpopulations in pancreas of prediabetic BB/E rats. Possible role for macrophages in pathogenesis of IDDM by Walker, R., Bone, A. J., Cooke, A., Baird, J. D.

“…Distinct macrophage subpopulations in pancreas of prediabetic BB/E rats. Possible role for macrophages in pathogenesis of IDDM. R Walker , A J Bone , A Cooke…”
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Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells by DEAN, B. M, WALKER, R, BONE, A. J, BAIRD, J. D, COOKE, A

“…Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading…”
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Timed interruption of insulin therapy in diabetic BB/E rat pregnancy: effect on maternal metabolism and fetal outcome by Eriksson, U J, Bone, A J, Turnbull, D M, Baird, J D

“…Experimental and clinical studies have suggested that periods of poor metabolic control in early diabetic pregnancy have an adverse effect on the developing…”
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One-bath dyeing of polyester/cotton blends with disperse and bis-3-carboxypyridinium-s-triazine reactive dyes. Part 2: Application of substantive reactive dyes to cotton at 130 °C and neutral pH by Bone, J A, Le, T T, Phillips, D A S, Taylor, J A

“…An earlier paper reported that the reactive dyes (not the disperse dyes) were responsible for the inability to achieve heavy depths of shade, when dyeing…”
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One-bath dyeing of polyester/cotton with disperse and bis-3-carboxypyridinium-s-triazine reactive dyes. Part 1: Factors limiting production of heavy shades by Bone, J A, Le, T T, Phillips, D A S, Taylor, J A

“…Over the last 20 years, selected disperse dyes and bis‐3‐carboxypyridinium‐s‐triazine reactive dyes have been widely promoted for the exhaust dyeing of…”
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Serum biopterin : a novel marker for immune activation during pre-diabetes in the BB rat by DAVIES, A. J, BONE, A. J, WILKIN, T. J, ROKOS, H, COLE, D. R

“…Tetrahydrobiopterin (BH4) is a pteridine product which is released by rodent macrophages on activation by cytokines. We have used serial pancreatic biopsy, and…”
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