Search Results - "Bondeson, Daniel P."

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  1. 1

    Targeted Protein Degradation by Small Molecules by Bondeson, Daniel P, Crews, Craig M

    “…Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been…”
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    Journal Article
  2. 2

    Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation by Burslem, George M, Schultz, Anna Reister, Bondeson, Daniel P, Eide, Christopher A, Savage Stevens, Samantha L, Druker, Brian J, Crews, Craig M

    Published in Cancer research (Chicago, Ill.) (15-09-2019)
    “…Although the use of ATP-competitive tyrosine kinase inhibitors of oncoprotein BCR-ABL1 has enabled durable responses in patients with chronic myeloid leukemia…”
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    Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead by Bondeson, Daniel P, Smith, Blake E, Burslem, George M, Buhimschi, Alexandru D, Hines, John, Jaime-Figueroa, Saul, Wang, Jing, Hamman, Brian D, Ishchenko, Alexey, Crews, Craig M

    Published in Cell chemical biology (18-01-2018)
    “…Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we report a previously understudied benefit of small molecule…”
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    Journal Article
  5. 5

    Ion and solute transport by Prestin in Drosophila and Anopheles by Hirata, Taku, Czapar, Anna, Brin, Lauren, Haritonova, Alyona, Bondeson, Daniel P, Linser, Paul, Cabrero, Pablo, Thompson, James, Dow, Julian A.T, Romero, Michael F

    Published in Journal of insect physiology (01-04-2012)
    “…[Display omitted] ► One Drosophila and two A. gambiae orthologues have high homology with mammalian Slc26a5 and Slc26a6. ► dPrestin and AgPrestin-B show…”
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  6. 6

    Scaffold hopping enables direct access to more potent PROTACs with in vivo activity by Burslem, George M, Bondeson, Daniel P, Crews, Craig M

    “…Herein we employ a scaffold hopping approach to enhance the activity of a previously reported BCR-Abl PROTAC. This represents a significant advance in the…”
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    An In Vitro Pull-down Assay of the E3 Ligase:PROTAC:Substrate Ternary Complex to Identify Effective PROTACs by Bondeson, Daniel P, Smith, Blake E, Buhimschi, Alexandru D

    “…Assessing the specificity of PROTACs and confirming their proposed mechanism of action are critical for a robust targeted protein degradation program. Owing to…”
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  9. 9

    The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study by Burslem, George M, Smith, Blake E, Lai, Ashton C, Jaime-Figueroa, Saul, McQuaid, Daniel C, Bondeson, Daniel P, Toure, Momar, Dong, Hanqing, Qian, Yimin, Wang, Jing, Crew, Andrew P, Hines, John, Crews, Craig M

    Published in Cell chemical biology (18-01-2018)
    “…Proteolysis targeting chimera (PROTAC) technology has emerged over the last two decades as a powerful tool for targeted degradation of endogenous proteins…”
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  10. 10

    In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis by Hirata, Taku, Cabrero, Pablo, Berkholz, Donald S, Bondeson, Daniel P, Ritman, Erik L, Thompson, James R, Dow, Julian A T, Romero, Michael F

    “…Nephrolithiasis is a major public health problem with a complex and varied etiology. Most stones are composed of calcium oxalate (CaOx), with dietary excess a…”
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    Real‐time visualization of calcium oxalate crystals in Drosophila ‐ a gut and renal model of kidney stones by Bondeson, Daniel P, Hirata, Taku, Cabrero, Pablo, Ritman, Erik L, Dow, Julian AT, Romero, Michael F

    Published in The FASEB journal (01-04-2012)
    “…Abstract only Background Kidney stones (nephrolithiasis) are an expensive and painful health problem with a complex etiology with ~70% of stones composed of…”
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