Search Results - "Bonder, Edward M"

Paneth Cell Multipotency Induced by Notch Activation following Injury by Yu, Shiyan, Tong, Kevin, Zhao, Yanlin, Balasubramanian, Iyshwarya, Yap, George S., Ferraris, Ronaldo P., Bonder, Edward M., Verzi, Michael P., Gao, Nan

“…Paneth cells are post-mitotic intestinal epithelial cells supporting the stem cell niche and mucosal immunity. Paneth cell pathologies are observed in various…”
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γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release by Hu, Madeleine D., Golovchenko, Natasha B., Burns, Grace L., Nair, Prema M., Kelly, Thomas J., Agos, Jonathan, Irani, Mudar Zand, Soh, Wai Sinn, Zeglinski, Matthew R., Lemenze, Alexander, Bonder, Edward M., Sandrock, Inga, Prinz, Immo, Granville, David J., Keely, Simon, Watson, Alastair J.M., Edelblum, Karen L.

“…Excessive shedding of apoptotic enterocytes into the intestinal lumen is observed in inflammatory bowel disease and is correlated with disease relapse. Based…”
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The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac by Chen, Lei, Luo, Shirley, Dupre, Abigail, Vasoya, Roshan P., Parthasarathy, Aditya, Aita, Rohit, Malhotra, Raj, Hur, Joseph, Toke, Natalie H., Chiles, Eric, Yang, Min, Cao, Weihuan, Flores, Juan, Ellison, Christopher E., Gao, Nan, Sahota, Amrik, Su, Xiaoyang, Bonder, Edward M., Verzi, Michael P.

“…The brush border is comprised of microvilli surface protrusions on the apical surface of epithelia. This specialized structure greatly increases absorptive…”
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Discovery of a Diverse Set of Bacteria That Build Their Cell Walls without the Canonical Peptidoglycan Polymerase aPBP by Atwal, Sharanjeet, Chuenklin, Suthida, Bonder, Edward M, Flores, Juan, Gillespie, Joseph J, Driscoll, Timothy P, Salje, Jeanne

“…Peptidoglycan (PG) is a highly cross-linked peptide-glycan mesh that confers structural rigidity and shape to most bacterial cells. Polymerization of new PG is…”
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A Wntless-SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export by Sun, Jiaxin, Yu, Shiyan, Zhang, Xiao, Capac, Catherine, Aligbe, Onyedikachi, Daudelin, Timothy, Bonder, Edward M, Gao, Nan

“…Wntless (Wls) transports Wnt molecules for secretion; however, the cellular mechanism underlying the initial assembly of Wnt secretory vesicles is still not…”
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Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy by Feng, Qiang, Bonder, Edward M, Engevik, Amy C, Zhang, Lanjing, Tyska, Matthew J, Goldenring, James R, Gao, Nan

“…Misplaced formation of microvilli to basolateral domains and intracellular inclusions in enterocytes are pathognomonic features in congenital enteropathy…”
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TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis by Yu, Shiyan, Nie, Yingchao, Knowles, Byron, Sakamori, Ryotaro, Stypulkowski, Ewa, Patel, Chirag, Das, Soumyashree, Douard, Veronique, Ferraris, Ronaldo P, Bonder, Edward M, Goldenring, James R, Ip, Yicktung Tony, Gao, Nan

“…Compartmentalization of Toll‐like receptors (TLRs) in intestinal epithelial cells (IECs) regulates distinct immune responses to microbes; however, the specific…”
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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling by D'Agostino, Luca, Nie, Yingchao, Goswami, Sayantani, Tong, Kevin, Yu, Shiyan, Bandyopadhyay, Sheila, Flores, Juan, Zhang, Xiao, Balasubramanian, Iyshwarya, Joseph, Ivor, Sakamori, Ryotaro, Farrell, Victoria, Li, Qi, Yang, Chung S, Gao, Bin, Ferraris, Ronaldo P, Yehia, Ghassan, Bonder, Edward M, Goldenring, James R, Verzi, Michael P, Zhang, Lanjing, Ip, Y Tony, Gao, Nan

“…The effects of polarized membrane trafficking in mature epithelial tissue on cell growth and cancer progression have not been fully explored . A majority of…”
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Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche by Das, Soumyashree, Yu, Shiyan, Sakamori, Ryotaro, Vedula, Pavan, Feng, Qiang, Flores, Juan, Hoffman, Andrew, Fu, Jiang, Stypulkowski, Ewa, Rodriguez, Alexis, Dobrowolski, Radek, Harada, Akihiro, Hsu, Wei, Bonder, Edward M, Verzi, Michael P, Gao, Nan

“…Communication between stem and niche supporting cells maintains the homeostasis of adult tissues. Wnt signaling is a crucial regulator of the stem cell niche,…”
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YY1 is indispensable for Lgr5⁺ intestinal stem cell renewal by Perekatt, Ansu O., Valdez, Michael J., Davila, Melanie, Hoffman, A., Bonder, Edward M., Gao, Nan, Verzi, Michael P.

“…The intestinal stem cell fuels the highest rate of tissue turnover in the body and has been implicated in intestinal disease and cancer; understanding the…”
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Global Ablation of the Mouse Rab11a Gene Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion by Yu, Shiyan, Yehia, Ghassan, Wang, Juanfei, Stypulkowski, Ewa, Sakamori, Ryotaro, Jiang, Ping, Hernandez-Enriquez, Berenice, Tran, Tracy S., Bonder, Edward M., Guo, Wei, Gao, Nan

“…Rab11a has been conceived as a prominent regulatory component of the recycling endosome, which acts as a nexus in the endo- and exocytotic networks. The…”
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CDC42 inhibition suppresses progression of incipient intestinal tumors by Sakamori, Ryotaro, Yu, Shiyan, Zhang, Xiao, Hoffman, Andrew, Sun, Jiaxin, Das, Soumyashree, Vedula, Pavan, Li, Guangxun, Fu, Jiang, Walker, Francesca, Yang, Chung S, Yi, Zheng, Hsu, Wei, Yu, Da-Hai, Shen, Lanlan, Rodriguez, Alexis J, Taketo, Makoto M, Bonder, Edward M, Verzi, Michael P, Gao, Nan

“…Mutations in the APC or β-catenin genes are well-established initiators of colorectal cancer, yet modifiers that facilitate the survival and progression of…”
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Weakly Coordinating Amphiphilic Organoborate Block Copolymers by Cui, Chengzhong, Bonder, Edward M, Jäkle, Frieder

“…Selective functionalization of polystyrene with weakly coordinating organoborate functionalities BAr4 − (Ar = Ph, C6F5) has been accomplished by a polymer…”
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Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration by Zhang, Xiao, Bandyopadhyay, Sheila, Araujo, Leandro Pires, Tong, Kevin, Flores, Juan, Laubitz, Daniel, Zhao, Yanlin, Yap, George, Wang, Jingren, Zou, Qingze, Ferraris, Ronaldo, Zhang, Lanjing, Hu, Wenwei, Bonder, Edward M, Kiela, Pawel R, Coffey, Robert, Verzi, Michael P, Ivanov, Ivaylo I, Gao, Nan

“…The regulatory mechanisms enabling the intestinal epithelium to maintain a high degree of regenerative capacity during mucosal injury remain unclear. Ex vivo…”
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Desmosome Disruption by Enteropathogenic E coli by Bandyopadhyay, Sheila, Bonder, Edward M., PhD, Gao, Nan, PhD

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HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice by Chen, Lei, Vasoya, Roshan P., Toke, Natalie H., Parthasarathy, Aditya, Luo, Shirley, Chiles, Eric, Flores, Juan, Gao, Nan, Bonder, Edward M., Su, Xiaoyang, Verzi, Michael P.

“…Functions of intestinal stem cells (ISCs) are regulated by diet and metabolic pathways. Hepatocyte nuclear factor 4 (HNF4) family are transcription factors…”
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Electron-Deficient Triarylborane Block Copolymers: Synthesis by Controlled Free Radical Polymerization and Application in the Detection of Fluoride Ions by Cheng, Fei, Bonder, Edward M, Jäkle, Frieder

“…Luminescent triarylborane homo and block copolymers with well-defined chain architectures were synthesized via reversible addition–fragmentation chain transfer…”
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TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy by Nnah, Israel C., Wang, Biao, Saqcena, Chaitali, Weber, Gregory F., Bonder, Edward M., Bagley, Dustin, De Cegli, Rossella, Napolitano, Gennaro, Medina, Diego L., Ballabio, Andrea, Dobrowolski, Radek

“…The mechanistic target of rapamycin kinase complex 1 (MTORC1) is a central cellular kinase that integrates major signaling pathways, allowing for regulation of…”
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Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine by Yu, Shiyan, Balasubramanian, Iyshwarya, Laubitz, Daniel, Tong, Kevin, Bandyopadhyay, Sheila, Lin, Xiang, Flores, Juan, Singh, Rajbir, Liu, Yue, Macazana, Carlos, Zhao, Yanlin, Béguet-Crespel, Fabienne, Patil, Karuna, Midura-Kiela, Monica T., Wang, Daniel, Yap, George S., Ferraris, Ronaldo P., Wei, Zhi, Bonder, Edward M., Häggblom, Max M., Zhang, Lanjing, Douard, Veronique, Verzi, Michael P., Cadwell, Ken, Kiela, Pawel R., Gao, Nan

“…Paneth cells are the primary source of C-type lysozyme, a β-1,4-N-acetylmuramoylhydrolase that enzymatically processes bacterial cell walls. Paneth cells are…”
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Salmonella engages CDC42 effector protein 1 for intracellular invasion by Bandyopadhyay, Sheila, Zhang, Xiao, Ascura, Andrea, Edelblum, Karen L., Bonder, Edward M., Gao, Nan

“…Human enterocytes are primary targets of infection by invasive bacterium Salmonella Typhimurium, and studies using nonintestinal epithelial cells established…”
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