Search Results - "Bond, Wesley S."

Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia by Bond, Wesley S, Rex, Tonia S

“…Neuroinflammation is a normal and healthy response to neuronal damage. However, excessive or chronic neuroinflammation exacerbates neurodegeneration after…”
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Inhibitors of metalloprotease, γ-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication by Liu, Alice, Ildefonso, Cristhian J, Bond, Wesley S, Hurwitz, Mary Y, Hurwitz, Richard L

“…Adenoviruses cause upper respiratory infections, conjunctivitis, keratitis, and gastrointestinal illness. These can be fatal in immunocompromised individuals…”
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Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa by Rex, Tonia S, Kasmala, Lorraine, Bond, Wesley S, de Lucas Cerrillo, Ana M, Wynn, Kristi, Lewin, Alfred S

“…To test the efficacy of systemic gene delivery of a mutant form of erythropoietin (EPO-R76E) that has attenuated erythropoietic activity, in a mouse model of…”
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Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin by Bond, Wesley S, Akinfenwa, Patricia Y, Perlaky, Laszlo, Hurwitz, Mary Y, Hurwitz, Richard L, Chévez-Barrios, Patricia

“…Verification that cell lines used for cancer research are derived from malignant cells in primary tumors is imperative to avoid invalidation of study results…”
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Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma by Bond, Wesley S, Hines-Beard, Jessica, GoldenMerry, YPaul L, Davis, Mara, Farooque, Alma, Sappington, Rebecca M, Calkins, David J, Rex, Tonia S

“…Glaucoma, a common cause of blindness, is currently treated by intraocular pressure (IOP)–lowering interventions. However, this approach is insufficient to…”
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Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress by Hines-Beard, Jessica, Bond, Wesley S, Backstrom, Jon R, Rex, Tonia S

“…Glaucoma is a complex neurodegeneration and a leading cause of blindness worldwide. Current therapeutic strategies, which are all directed towards lowering the…”
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Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways by Akinfenwa, Patricia Y., Bond, Wesley S., Ildefonso, Cristhian J., Hurwitz, Mary Y., Hurwitz, Richard L.

“…To examine the biochemical influences that may contribute to the success of gene therapy for ocular disorders, the role of versican, a vitreous component, in…”
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Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells by Wadhwa, Lalita, Bond, Wesley S, Perlaky, Laszlo, Overbeek, Paul A, Hurwitz, Mary Y, Chévez-Barrios, Patricia, Hurwitz, Richard L

“…Human retinoblastomas form during the proliferative phase of retina development and are caused by mutations that result in absent or functionally defective Rb…”
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The Liberation of CD44 Intracellular Domain Modulates Adenoviral Vector Transgene Expression by Ildefonso, Cristhian J., Bond, Wesley S., Al-Tawashi, Azza R., Hurwitz, Mary Y., Hurwitz, Richard L.

“…The success of gene therapy in the ocular environment is partly due to the presence of hyaluronan in vitreous. Here we explore the mechanism of…”
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Establishment and propagation of human retinoblastoma tumors in immune deficient mice by Bond, Wesley S, Wadhwa, Lalita, Perlaky, Laszlo, Penland, Rebecca L, Hurwitz, Mary Y, Hurwitz, Richard L, Chèvez-Barrios, Patricia

“…Culturing retinoblastoma tumor cells in defined stem cell media gives rise to primary tumorspheres that can be grown and maintained for only a limited time…”
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Inhibitors of metalloprotease, [gamma]-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication by Liu, Alice, Ildefonso, Cristhian J, Bond, Wesley S, Hurwitz, Mary Y, Hurwitz, Richard L

“…Adenoviruses cause upper respiratory infections, conjunctivitis, keratitis, and gastrointestinal illness. These can be fatal in immunocompromised individuals…”
Get full text

108. Versican G1 Domain Stimulates Adenoviral Transgene Expression in a JAK/STAT Dependent Manner by Akinfenwa, Patricia, Bond, Wesley S., Ildefonso, Cristian J., Hurwitz, Mary Y., Hurwitz, Richard L.

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204. Treatment with Modified Erythropoietin Gene Therapy Is Neuroprotective in a Mouse Model of Induced Ocular Hypertension by Bond, Wesley S., Chang, YPaul L., Davis, Mara N., Sappington, Rebecca M., Rex, Tonia S.

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Safety and angiogenic effects of systemic gene delivery of a modified erythropoietin by de Lucas Cerrillo, A M, Bond, W S, Rex, T S

“…Erythropoietin (EPO) is critical for red blood cell production and is also an effective neuroprotective agent. However, it may contribute to pathological…”
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Evaluation of porcine aortic valve interstitial cell activity using different serum types in two- and three-dimensional culture by Bond, Wesley S, Roberts, Erin L, Warnock, James N

“…Unlike established cell lines used in the biotechnology industry, primary cells used in tissue engineering require culture media to be supplemented with serum…”
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Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice by Bond, Wesley S., Wadhwa, Lalita, Perlaky, Laszlo, Penland, Rebecca L., Hurwitz, Mary Y., Hurwitz, Richard L., Chèvez-Barrios, Patricia

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