Search Results - "Bond, Susan M"

Transfer RNA and human disease by Abbott, Jamie A, Francklyn, Christopher S, Robey-Bond, Susan M

“…Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA)…”
Get full text

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity by Abbott, Jamie A, Guth, Ethan, Kim, Cindy, Regan, Cathy, Siu, Victoria M, Rupar, C. Anthony, Demeler, Borries, Francklyn, Christopher S, Robey-Bond, Susan M

“…Histidyl-tRNA synthetase (HARS) is a highly conserved translation factor that plays an essential role in protein synthesis. HARS has been implicated in the…”
Get full text

Probing the activity of NTHL1 orthologs by targeting conserved amino acid residues by Robey-Bond, Susan M., Benson, Meredith A., Barrantes-Reynolds, Ramiro, Bond, Jeffrey P., Wallace, Susan S.

“…•E. coli Asp44 plays a different role than its homologous residue in human NTHL1.•hNTHL1 Gln287 in involved in opposite base specificity as well as…”
Get full text

Clostridium acetobutylicum 8-Oxoguanine DNA Glycosylase (Ogg) Differs from Eukaryotic Oggs with Respect to Opposite Base Discrimination by Robey-Bond, Susan M, Barrantes-Reynolds, Ramiro, Bond, Jeffrey P, Wallace, Susan S, Bandaru, Viswanath

“…During repair of damaged DNA, the oxidized base 8-oxoguanine (8-oxoG) is removed by 8-oxoguanine−DNA glycosylase (Ogg) in eukaryotes and most archaea, whereas…”
Get full text

Pressure application measurement (PAM): A novel behavioural technique for measuring hypersensitivity in a rat model of joint pain by Barton, Nicola J., Strickland, Iain T., Bond, Susan M., Brash, Harry M., Bate, Simon T., Wilson, Alex W., Chessell, Iain P., Reeve, Alison J., McQueen, Daniel S.

“…Chronic joint pain affects physical well being and can lead to severe psychological and social problems, therefore successful long-term management is highly…”
Get full text

Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease by Ferrington, Linda, Miners, J Scott, Palmer, Laura E, Bond, Susan M, Povey, Joanne E, Kelly, Paul At, Love, Seth, Horsburgh, Karen J, Kehoe, Patrick G

“…Reducing the excessive accumulation of amyloid β-protein (Aβ) in Alzheimer's disease (AD) is a key objective of most AD therapies. Several studies suggest that…”
Get full text

Structural Characterization of Clostridium acetobutylicum 8-Oxoguanine DNA Glycosylase in Its Apo Form and in Complex with 8-Oxodeoxyguanosine by Faucher, Frédérick, Robey-Bond, Susan M., Wallace, Susan S., Doublié, Sylvie

“…DNA is subject to a multitude of oxidative damages generated by oxidizing agents from metabolism and exogenous sources and by ionizing radiation. Guanine is…”
Get full text

Antagonist inhibition curves and the measurement of dissociation constants by Barlow, R B, Bond, Susan M, Bream, Elizabeth, Macfarlane, Lisa, McQueen, D S

“…Experiments carried out on guinea‐pig isolated ileum with carbachol as agonist and diphenyl‐ acetoxyethyl‐ dimethyl‐ethyl‐ ammonium (DADMEA) bromide as…”
Get full text

Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats by McQueen, Daniel S, Bond, Susan M, Smith, Paula J.W, Balali-Mood, Kia, Smart, Darren

“…The results of vasorespiratory studies in rats anaesthetised with pentobarbital show that (±) cannabidiol, a cannabinoid that lacks psychotropic actions and is…”
Get full text

A comparison of effects measured with isotonic and isometric recording: I. Concentration‐effect curves for agonists by Barlow, R B, Bond, Susan M, Grant, Claire, McQueen, D S, Yaqoob, Zeenat

“…Concentration‐effect curves were obtained with carbachol tested on isolated preparations of guinea‐pig ileum taken from adjacent sites in the same animal, one…”
Get full text

A comparison of effects measured with isotonic and isometric recording: II. Concentration‐effect curves for physiological antagonists by Barlow, R B, Bond, Susan M, Grant, Claire, McQueen, D S, Yaqoob, Zeenat

“…If one drug, B, antagonizes another, A, by producing the opposite physiological effect, the antagonist concentration‐effect curves should be affected by the…”
Get full text

Managing value conflicts : an examination of values and value conflicts in third sector organisations in Scotland by Bond, Susan M

“…The purpose of this thesis is to provide an understanding of value conflicts and how they are managed within third sector organisations in Scotland,…”
Get full text

Structural Characterization of Clostridium acetobutylicum 8-Oxoguanine DNA Glycosylase in Its Apo Form and in Complex with 8-Oxodeoxyguanosine by Faucher, Frédérick, Robey-Bond, Susan M., Wallace, Susan S., Doublié, Sylvie

Get full text

Clostridium acetobutylicum 8-Oxoguanine DNA Glycosylase (Ogg) Differs from Eukaryotic Oggs with Respect to Opposite Base Discrimination super([dagger]) by Barrantes-Reynolds, Ramiro, Robey-Bond, Susan M, Wallace, Susan S, Bond, Jeffrey P, Bandaru, Viswanath

“…During repair of damaged DNA, the oxidized base 8-oxoguanine (8-oxoG) is removed by 8-oxoguanine-DNA glycosylase (Ogg) in eukaryotes and most archaea, whereas…”
Get full text

A comparison of effects measured with isotonic and isometric recording: I. Concentration‐effect curves for agonists by Barlow, R B, Bond, Susan M, Grant, Claire, McQueen, D S, Yaqoob, Zeenat

“…British Journal of Pharmacology (2001) 134, 1596; doi:10.1038/sj.bjp.0704392…”
Get full text

Selective blockade of M 2 and M 3 muscarinic receptors by hexahydrobenzyl‐ fourdapine and a comparison with zamifenacin by Barlow, R.B., Bond, Susan M., Branthwaite, A.G., Jackson, O., McQueen, D.S., Smith, Kirsten M., Smith, Paula J.

“…4‐Diphenylacetoxy‐N‐ cyclo hexylmethyl‐piperidine HC1 (hexahydro‐benz‐4DAP) is more active as an antagonist of carbachol at receptors in guinea‐pig isolated…”
Get full text

Selective blockade of M2 and M3 muscarinic receptors by hexahydrobenzyl‐ fourdapine and a comparison with zamifenacin by Barlow, R.B., Bond, Susan M., Branthwaite, A.G., Jackson, O., McQueen, D.S., Smith, Kirsten M., Smith, Paula J.

“…1 4‐Diphenylacetoxy‐N‐cyclohexylmethyl‐piperidine HC1 (hexahydro‐benz‐4DAP) is more active as an antagonist of carbachol at receptors in guinea‐pig isolated…”
Get full text

INFLUENCE OF NEONATALLY ADMINISTERED CAPSAICIN ON BARORECEPTOR AND CHEMORECEPTOR REFLEXES IN THE ADULT RAT by BOND, SUSAN M., CERVERO, F., McQUEEN, D.S.

“…1 Baroreceptor and chemoreceptor reflex activity was studied in anaesthetized adult rats which had been treated neonatally with a single injection of capsaicin…”
Get full text