Search Results - "Bond, Jeffrey P"

Global analysis of the sporulation pathway of Clostridium difficile by Fimlaid, Kelly A, Bond, Jeffrey P, Schutz, Kristin C, Putnam, Emily E, Leung, Jacqueline M, Lawley, Trevor D, Shen, Aimee

“…The Gram-positive, spore-forming pathogen Clostridium difficile is the leading definable cause of healthcare-associated diarrhea worldwide. C. difficile…”
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A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma by Saulnier Sholler, Giselle L, Gerner, Eugene W, Bergendahl, Genevieve, MacArthur, Robert B, VanderWerff, Alyssa, Ashikaga, Takamaru, Bond, Jeffrey P, Ferguson, William, Roberts, William, Wada, Randal K, Eslin, Don, Kraveka, Jacqueline M, Kaplan, Joel, Mitchell, Deanna, Parikh, Nehal S, Neville, Kathleen, Sender, Leonard, Higgins, Timothy, Kawakita, Masao, Hiramatsu, Kyoko, Moriya, Shun-Suke, Bachmann, André S

“…Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extracranial solid tumors in children. Ornithine decarboxylase…”
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mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo by Liu, Minmin, Bandaru, Viswanath, Bond, Jeffrey P, Jaruga, Pawel, Zhao, Xiaobei, Christov, Plamen P, Burrows, Cynthia J, Rizzo, Carmelo J, Dizdaroglu, Miral, Wallace, Susan S

“…To protect cells from oxidative DNA damage and mutagenesis, organisms possess multiple glycosylases to recognize the damaged bases and to initiate the Base…”
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The Crystal Structure of Human Endonuclease VIII-Like 1 (NEIL1) Reveals a Zincless Finger Motif Required for Glycosylase Activity by Doublié, Sylvie, Bandaru, Viswanath, Bond, Jeffrey P., Wallace, Susan S., Setlow, Richard B.

“…In prokaryotes, two DNA glycosylases recognize and excise oxidized pyrimidines: endonuclease III (Nth) and endonuclease VIII (Nei). The oxidized purine…”
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Histamine H3 Receptor Integrates Peripheral Inflammatory Signals in the Neurogenic Control of Immune Responses and Autoimmune Disease Susceptibility by Krementsov, Dimitry N., Wall, Emma H., Martin, Rebecca A., Subramanian, Meenakumari, Noubade, Rajkumar, Rio, Roxana Del, Mawe, Gary M., Bond, Jeffrey P., Poynter, Matthew E., Blankenhorn, Elizabeth P., Teuscher, Cory

“…Histamine H3 receptor (Hrh3/H3R) is primarily expressed by neurons in the central nervous system (CNS) where it functions as a presynaptic inhibitory…”
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Genome-Wide Characterization of the SloR Metalloregulome in Streptococcus mutans by O'Rourke, Kevin P, Shaw, Jeremy D, Pesesky, Mitchell W, Cook, Brian T, Roberts, Susanne M, Bond, Jeffrey P, Spatafora, Grace A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Using shifts in amino acid frequency and substitution rate to identify latent structural characters in base-excision repair enzymes by Barrantes-Reynolds, Ramiro, Wallace, Susan S, Bond, Jeffrey P

“…Protein evolution includes the birth and death of structural motifs. For example, a zinc finger or a salt bridge may be present in some, but not all, members…”
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Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C by del Rio, Roxana, McAllister, Ryan D, Meeker, Nathan D, Wall, Emma H, Bond, Jeffrey P, Kyttaris, Vasileios C, Tsokos, George C, Tung, Kenneth S K, Teuscher, Cory

“…Experimental autoimmune orchitis (EAO), the principal model of non-infectious testicular inflammatory disease, can be induced in susceptible mouse strains by…”
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Methylation-Controlled J Protein Promotes c-Jun Degradation To Prevent ABCB1 Transporter Expression by Hatle, Ketki M., Neveu, Wendy, Dienz, Oliver, Rymarchyk, Stacia, Barrantes, Ramiro, Hale, Sarah, Farley, Nicholas, Lounsbury, Karen M., Bond, Jeffrey P., Taatjes, Douglas, Rincón, Mercedes

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Utilization of Gene Profiling and Proteomics to Determine Mineral Pathogenicity in a Human Mesothelial Cell Line (LP9/TERT-1) by Hillegass, Jedd M., Shukla, Arti, MacPherson, Maximilian B., Bond, Jeffrey P., Steele, Chad, Mossman, Brooke T.

“…Identifying and understanding the early molecular events that underscore mineral pathogenicity using in vitro screening tests is imperative, especially given…”
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Maintenance DFMO Increases Survival in High Risk Neuroblastoma by Sholler, Giselle L. Saulnier, Ferguson, William, Bergendahl, Genevieve, Bond, Jeffrey P., Neville, Kathleen, Eslin, Don, Brown, Valerie, Roberts, William, Wada, Randal K., Oesterheld, Javier, Mitchell, Deanna, Foley, Jessica, Parikh, Nehal S., Eshun, Francis, Zage, Peter, Rawwas, Jawhar, Sencer, Susan, Pankiewicz, Debra, Quinn, Monique, Rich, Maria, Junewick, Joseph, Kraveka, Jacqueline M.

“…High risk neuroblastoma (HRNB) accounts for 15% of all pediatric cancer deaths. Despite aggressive therapy approximately half of patients will relapse,…”
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The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells by Dienz, Oliver, Eaton, Sheri M, Bond, Jeffrey P, Neveu, Wendy, Moquin, David, Noubade, Rajkumar, Briso, Eva M, Charland, Colette, Leonard, Warren J, Ciliberto, Gennaro, Teuscher, Cory, Haynes, Laura, Rincon, Mercedes

“…Interleukin (IL) 6 is a proinflammtory cytokine produced by antigen-presenting cells and nonhematopoietic cells in response to external stimuli. It was…”
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Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma by Lozier, Ann M, Rich, Maria E, Grawe, Anissa Pedersen, Peck, Anderson S, Zhao, Ping, Chang, Anthony Ting-Tung, Bond, Jeffrey P, Sholler, Giselle Saulnier

“…LIN28 has emerged as an oncogenic driver in a number of cancers, including neuroblastoma (NB). Overexpression of LIN28 correlates with poor outcome in NB,…”
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The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns by Fortner, Karen A, Bond, Jeffrey P, Austin, James W, Boss, Jeremy M, Budd, Ralph C

“…Abstract T lymphocyte homeostatic proliferation, driven by the engagement of T cell antigen receptor with self-peptide/major histocompatibility complexes, and…”
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Engineering Functional Changes in Escherichia coli Endonuclease III Based on Phylogenetic and Structural Analyses by Watanabe, Takashi, Blaisdell, Jeffrey O., Wallace, Susan S., Bond, Jeffrey P.

“…Escherichia coli endonuclease III (EcoNth) plays an important cellular role by removing premutagenic pyrimidine damages produced by reactive oxygen species…”
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RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects by Silva, Michelle C., Morrical, Milagros D., Bryan, Katie E., Averill, April M., Dragon, Julie, Bond, Jeffrey P., Morrical, Scott W.

“…[Display omitted] •RAD51 tumor variants Q268P and Q272L occur in the DNA binding loop 2 (L2) region.•Variants show abnormal thermal stability, DNA binding, and…”
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Abstract 68: Neuroblastoma drug response profiles are associated with gene expression profiles by Bond, Jeffrey P., VanSickle, Elizabeth, Dexhemier, Thomas S., Neubig, Richard R., Sholler, Giselle L.

“…Abstract Background: High risk neuroblastoma patients have a poor response to initial chemotherapy, with 20% unable to achieve a complete response. Genomic…”
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Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR) by Chan, Philip A., Duraisamy, Sekhar, Miller, Peter J., Newell, Joan A., McBride, Carole, Bond, Jeffrey P., Raevaara, Tiina, Ollila, Saara, Nyström, Minna, Grimm, Andrew J., Christodoulou, John, Oetting, William S., Greenblatt, Marc S.

“…The human genome contains frequent single‐basepair variants that may or may not cause genetic disease. To characterize benign vs. pathogenic missense variants,…”
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Probing the activity of NTHL1 orthologs by targeting conserved amino acid residues by Robey-Bond, Susan M., Benson, Meredith A., Barrantes-Reynolds, Ramiro, Bond, Jeffrey P., Wallace, Susan S.

“…•E. coli Asp44 plays a different role than its homologous residue in human NTHL1.•hNTHL1 Gln287 in involved in opposite base specificity as well as…”
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A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII by Bandaru, Viswanath, Sunkara, Sirisha, Wallace, Susan S, Bond, Jeffrey P

“…Prokaryotes and lower eukaryotes possess redundant activities that remove the plethora of oxidative DNA base damages produced during normal oxidative…”
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