Testing of Selected Workplace Chemicals for Teratogenic Potential

The reproductive toxicity and teratogenic potential of 19 industrial chemitals have been investigated during the past 3 a. Preliminary studies utilizing intraperitoneal treatments of rats on days 1—15 of gestation have been conducted on the following ten chemicals: allyl chloride, bisphenol A, coppe...

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Bibliographic Details
Published in:	Scandinavian Journal of Work, Environment ＆ Health Vol. 7; no. 4; pp. 66 - 75
Main Authors:	Hardin, Bryan D, Bond, Gary P, Sikov, MR, Andrew, FD, Beliles, Robert P, Niemeier, Richard W
Format:	Journal Article
Language:	English
Published:	Finland Scandinavian Journal of Work, Environment ＆ Health 01-01-1981 National Board of Occupational Safety and Health The Working Environment Fund Swedish Medical Society, Section for Environmental Health Work Research Institutes Institute of Occupational Health
Subjects:	Abnormalities, Drug-Induced Animals Bisphenols Body weight Chemical hazards Chemical Industry Chlorides Ethylene Glycols - toxicity Female Fetal Death - chemically induced Fetus Inhalation Maternal-Fetal Exchange Oxides Pregnancy Rabbits Rats Rats, Inbred Strains Reproduction - drug effects REPRODUCTIVE EFFECTS Styrenes Teratogens - administration & dosage Teratogens - toxicity methyl styrene copper naphthenate trichloroethylene naphthalene nitrous oxide carbon disulfide 2-ethoxyethanol ethylene dibromide 2-nitropropane butylene oxide 1,2,3-tricll1oropropane ethyl benzene styrene oxide allyl chloride teratogenesis hexaohlorobutadiene reproductive toxicity tetrach1oroethylene bisphenol A 2-mercaptobenzothiazole
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Summary:	The reproductive toxicity and teratogenic potential of 19 industrial chemitals have been investigated during the past 3 a. Preliminary studies utilizing intraperitoneal treatments of rats on days 1—15 of gestation have been conducted on the following ten chemicals: allyl chloride, bisphenol A, copper napihthenate, etihylene d'ibromide, hexachlorobutadiene, Enmercaptobenzotniazole, methyl styrene, naphthalene, 2-nitropropane, and 1,2,3-trichloropropane. Studies utilizing inhalation exposure of rats and rabbits on days 1—19 and 1—24, respectively, of gestation have been conducted on the following nine chemicals: butylène oxide, carbon disulfide, 2-ethoxyethanol, ethyl benzene, methyl bromide, nitrous oxide, styrene oxide, tetrachloroethylene, and tridhloroethylene. In the preliminary studies, evidence of teratogenic potential was seen with allyl chloride and bisphenol A, and fetal toxicity was found in the absence of maternal toxicity with methyl styrene and 2-nitropropane. In the inhalation studies, 2-ethoxyethanol was strongly embryotoxic at the higher exposure levels employed and was teratogenic at the lower concentration.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-2 ObjectType-Feature-1 content type line 23 SourceType-Conference Papers & Proceedings-1 ObjectType-Conference-3
ISSN:	0355-3140 1795-990X