Search Results - "Bonato, V L D"

Recombinant DNA immunotherapy ameliorate established airway allergy in a IL-10 dependent pathway by Fonseca, D. M., Wowk, P. F., Paula, M. O., Campos, L. W., Gembre, A. F., Turato, W. M., Ramos, S. G., Dias-Baruffi, M., Barboza, R., Gomes, E., Silva, C. L., Russo, M., Bonato, V. L. D.

“…Summary Background Previous studies have established that mycobacterial infections ameliorate allergic inflammation. However, a non‐infectious approach that…”
Get full text

Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice by SILVA, C. L, BONATO, V. L. D, COELHO-CASTELO, A. A. M, DE SOUZA, A. O, SANTOS, S. A, LIMA, K. M, FACCIOLI, L. H, RODRIGUES, J. M

“…Tuberculosis (TB) remains a threat for public health, killing around 3 million people a year. Despite the fact that most cases can be cured with antibiotics,…”
Get full text

M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection by Piñeros, A. R., Campos, L. W., Fonseca, D. M., Bertolini, T. B., Gembre, A. F., Prado, R. Q., Alves-Filho, J. C., Ramos, S. G., Russo, M., Bonato, V. L. D.

“…The protective effects of mycobacterial infections on lung allergy are well documented. However, the inverse relationship between tuberculosis and type 2…”
Get full text

Attenuation of experimental asthma by mycobacterial protein combined with CpG requires a TLR9-dependent IFN-[gamma]-CCR2 signalling circuit by Prado, R Q, Bertolini, T B, Pineros, A R, Gembre, A F, Ramos, S G, Silva, C L, Borges, M C, Bonato, V L D

“…Summary Background Allergic asthma is a chronic pulmonary disease characterized by a Th2 inflammatory response. The modulation of a Th2 immune response based…”
Get full text

Attenuation of experimental asthma by mycobacterial protein combined with CpG requires a TLR9-dependent IFN-γ-CCR2 signalling circuit by Prado, R. Q., Bertolini, T. B., Piñeros, A. R., Gembre, A. F., Ramos, S. G., Silva, C. L., Borges, M. C., Bonato, V. L. D.

“…Summary Background Allergic asthma is a chronic pulmonary disease characterized by a Th2 inflammatory response. The modulation of a Th2 immune response based…”
Get full text

Requirement of MyD88 and Fas pathways for the efficacy of allergen‐free immunotherapy by Fonseca, D. M., Wowk, P. F., Paula, M. O., Gembre, A. F., Baruffi, M. D., Fermino, M. L., Turato, W. M., Campos, L. W., Silva, C. L., Ramos, S. G., Horn, C., Marchal, G., Arruda, L. K., Russo, M., Bonato, V. L. D.

“…Background We have shown that mycobacterial antigens and CpG oligodeoxynucleotides downmodulate airway allergic inflammation by mechanisms dependent on T‐cell…”
Get full text

Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon‐γ recovery and reduction of lung injury by Bonato, V. L. D., Gonçalves, E. D. C., Soares, E. G., Júnior, R. R. Santos, Sartori, A., Coelho‐Castelo, A. A. M., Silva, C. L.

“…Summary A DNA vaccine based on the heat‐shock protein 65 Mycobacterium leprae gene (pHSP65) presented a prophylactic and therapeutic effect in an experimental…”
Get full text

Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection by Franco, L H, Paula, M Oliveira e, Wowk, P F, Fonseca, D M da, Sérgio, C A, Fedatto, P F, Gembre, A F, Ramos, S G, Silva, C L, Medeiros, A I, Faccioli, L H, Bonato, V L D

“…Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma,…”
Get full text

Histoplasma capsulatum Inhibits Apoptosis and Mac‐1 Expression in Leucocytes by MEDEIROS, A. I., BONATO, V. L. D., MALHEIRO, A., DIAS, A. R. V., SILVA, C. L., FACCIOLI, L. H.

“…Histoplasma capsulatum is a fungus found intracellularly in neutrophils and peripheral blood mononuclear cells (PBMCs), suggesting that it is capable of…”
Get full text

Genetic Aspects and Microenvironment Affect Expression of CD18 and VLA‐4 in Experimental Tuberculosis by BONATO, V. L. D., GONÇALVES, E. D. C., SANTOS, R. R., SILVA, C. L.

“…Control of infection by Mycobacterium tuberculosis is dependent on macrophage activation and efficient migration of effector T‐cell populations. Lymphocyte…”
Get full text

Downmodulation of CD18 and CD86 on Macrophages and VLA‐4 on Lymphocytes in Experimental Tuberculosis by Bonato, V. L. D., Medeiros, A. I., Lima, V. M. F., Dias, A. R., Faccioli, L. H., Silva, C. L.

“…Development and evaluation of new vaccines and immunotherapy against tuberculosis demand a better understanding of the immune mechanisms in this disease…”
Get full text

Attenuation of experimental asthma by mycobacterial protein combined with CpG requires a TLR 9‐dependent IFN ‐γ‐ CCR 2 signalling circuit by Prado, R. Q., Bertolini, T. B., Piñeros, A. R., Gembre, A. F., Ramos, S. G., Silva, C. L., Borges, M. C., Bonato, V. L. D.

Get full text

Requirement of M y D 88 and F as pathways for the efficacy of allergen‐free immunotherapy by Fonseca, D. M., Wowk, P. F., Paula, M. O., Gembre, A. F., Baruffi, M. D., Fermino, M. L., Turato, W. M., Campos, L. W., Silva, C. L., Ramos, S. G., Horn, C., Marchal, G., Arruda, L. K., Russo, M., Bonato, V. L. D.

Get full text

Therapy of tuberculosis in mice by DNA vaccination by Lowrie, Douglas B, Tascon, Ricardo E, Bonato, Vania L. D, Lima, Valeria M. F, Faccioli, Lucia H, Stavropoulos, Evangelos, Colston, M. Joseph, Hewinson, Robert G, Moelling, Karin, Silva, Celio L

“…Mycobacterium tuberculosis continues to kill about 3 million people every year, more than any other single infectious agent. This is attributed primarily to an…”
Get full text

Identification and Characterization of Protective T Cells in hsp65 DNA-Vaccinated and Mycobacterium tuberculosis-Infected Mice by BONATO, V. L. D, LIMA, V. M. F, TASCON, R. E, LOWRIE, D. B, SILVA, C. L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis by Fonseca, D.M., Bonato, V.L.D., Silva, C.L., Sartori, A.

“…We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also…”
Get full text

Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis by Fonseca, D M, Bonato, V L D, Silva, C L, Sartori, A

“…We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also…”
Get full text

Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery by Coelho-Castelo, A A M, Trombone, A P, Rosada, R S, Santos, Jr, R R, Bonato, V L D, Sartori, A, Silva, C L

“…In order to assess a new strategy of DNA vaccine for a more complete understanding of its action in immune response, it is important to determine the in vivo…”
Get full text

Characterization of the memory/activated T cells that mediate the long‐lived host response against tuberculosis after bacillus Calmette–Guérin or DNA vaccination by Silva, CL, Bonato, VLD, Lima, VMF, Faccioli, L H, Leao, S C

“…The memory/activated T cells, which mediate the long‐lived host response against tuberculosis, in mice immunized with either bacillus Calmette–Guérin (BCG) or…”
Get full text

Characterization of the memory/activated T cells that mediate the long-lived host response against tuberculosis after bacillus Calmett--Guerin or DNA vaccination by Silva, C L, Bonato, V L D, Lima, V M F, Faccioli, L H, Leao, S C

Get full text