Search Results - "Bonamassa, Barbara"
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Atherosclerosis: lessons from LXR and the intestine
Published in Trends in endocrinology and metabolism (01-03-2013)“…Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis…”
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The roles of hepatitis B virus-encoded X protein in virus replication and the pathogenesis of chronic liver disease
Published in Expert opinion on therapeutic targets (01-03-2014)“…Hepatitis B virus (HBV) is a major cause of chronic liver disease (CLD) and hepatocellular carcinoma (HCC) worldwide. More than 350 million people are at risk…”
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ADAR enzyme and miRNA story: a nucleotide that can make the difference
Published in International Journal of Molecular Sciences (19-11-2013)“…Adenosine deaminase acting on RNA (ADAR) enzymes convert adenosine (A) to inosine (I) in double-stranded (ds) RNAs. Since Inosine is read as Guanosine, the…”
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Nonviral gene transfer as a tool for studying transcription regulation of xenobiotic metabolizing enzymes
Published in Advanced drug delivery reviews (30-10-2010)“…Numerous xenobiotic metabolizing enzymes are regulated by nuclear receptors at transcriptional level. The challenge we currently face is to understand how a…”
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Glucoraphasatin and Glucoraphenin, a Redox Pair of Glucosinolates of Brassicaceae, Differently Affect Metabolizing Enzymes in Rats
Published in Journal of agricultural and food chemistry (11-07-2007)“…Brassica vegetables are an important dietary source of glucosinolates (GLs), whose breakdown products exhibit anticancer activity. The protective properties of…”
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The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity
Published in Molecular and cellular endocrinology (15-10-2009)“…Chronic exposure to high free fatty acids (FFA) can lead to irreversible damage of beta-cell accounting for impaired insulin secretion. Multiple mechanisms…”
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Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research
Published in Pharmaceutical research (01-04-2011)“…Hydrodynamic delivery has emerged as the simplest and most effective method for intracellular delivery of membrane-impermeable substances in rodents. The…”
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Harmful effects behind the daily supplementation of a fixed vegetarian blend in the rat model
Published in Food and chemical toxicology (01-11-2016)“…Fruit and vegetables (FV) have long been considered a panacea against major chronic diseases, including cancer. However, there is no convincing…”
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Non-Viral Gene Transfer as a Tool for Studying Transcription Regulation of Xenobiotic Metabolizing Enzymes
Published in Advanced drug delivery reviews (14-08-2010)“…Numerous xenobiotic metabolizing enzymes are regulated by nuclear receptors at transcriptional level. The challenge we currently face is to understand how a…”
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Thromboembolic events and haematological diseases: a case of stroke as clinical onset of a paroxysmal nocturnal haemoglobinuria
Published in Thrombosis journal (11-11-2004)“…Some haematological diseases are associated to an increased risk of thromboembolic events. We report a case of paroxysmal nocturnal haemoglobinuria (PNH) in…”
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Glucocorticoid Receptor-Mediated Transcriptional Regulation of N-acetyltransferase 1 Gene Through Distal Promoter
Published in The AAPS journal (01-09-2012)“…ABSTRACT Human arylamine N -acetyltransferase 1, (HUMAN) NAT1 , is a phase II xenobiotic-metabolizing enzyme that plays an important role in drug and…”
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Glucocorticoid Receptor‐Mediated Transcriptional Regulation of N‐acetyltransferase 1 Gene through Distal Promoter
Published in The FASEB journal (01-04-2012)“…Abstract only Human arylamine N‐acetyltransferase 1, HUMAN(NAT1) plays important roles in drug and carcinogen biotransformation and cancer development. Its…”
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Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-08-2015)“…Despite more than 50 years of investigations into the free radical theory, the direct role of oxidative stress (OS) in aging and age-related diseases remains…”
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Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis
Published in Muscle & nerve (01-04-2009)“…Mice bearing the mutated gene for Cu/Zn superoxide dismutase (G93A) are a good model for human amyotrophic lateral sclerosis (ALS). They develop progressive…”
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Hepatitis C virus and host cell nuclear transport machinery: a clandestine affair
Published in Frontiers in microbiology (19-06-2015)“…There is growing evidence that factors encoded by cytoplasmic replicating viruses functionally interact with components of the nucleocytoplasmic transport…”
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High-dose vitamin A
Published in The Lancet (British edition) (01-09-2007)Get full text
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The novel radical scavenger IAC is effective in preventing and protecting against post-ischemic brain damage in Mongolian gerbils
Published in Journal of the neurological sciences (15-03-2010)“…Abstract The removal of pathologically generated free radicals produced during ischemia, reperfusion and intracranical hemorrhage seems to be a viable approach…”
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