Search Results - "Bonache, M. Angeles"

Recent Progress in TRPM8 Modulation: An Update by González-Muñiz, Rosario, Bonache, M Angeles, Martín-Escura, Cristina, Gómez-Monterrey, Isabel

“…The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion channel, activated by low temperatures (<28 °C), pressure, and…”
Get full text

Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists by de la Torre-Martínez, Roberto, Bonache, M. Angeles, Llabrés-Campaner, Pedro J., Balsera, Beatriz, Fernández-Carvajal, Asia, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Pérez de Vega, M. Jesús, González-Muñiz, Rosario

“…The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation…”
Get full text

Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity by Bonache, M.Ángeles, Martín-Escura, Cristina, de la Torre Martínez, Roberto, Medina, Alicia, González-Rodríguez, Sara, Francesch, Andrés, Cuevas, Carmen, Roa, Ana María, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Fernández-Carvajal, Asia, González-Muñiz, Rosario

“…The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold…”
Get full text

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides by Núñez-Villanueva, Diego, Bonache, M. Ángeles, Infantes, Lourdes, García-López, M. Teresa, Martín-Martínez, Mercedes, González-Muñiz, Rosario

“…To explore further the chemistry of amino acid-derived β-lactams, their conversion to α,α-heterocyclic quaternary amino acid derivatives is investigated. The…”
Get full text

Skeletal Transformations Observed in the Reaction of a Tricyclic Thymine Nucleoside with Dicarbonyl Compounds by Bonache, María-Cruz, -Doyagüez, Elisa G, Benito-Arenas, Raúl, Bonache, M Angeles, Jimeno, María-Luisa, San-Félix, Ana

“…Some intriguing skeletal transformations were observed in the reaction of α-hydroxypyrrolidine thymine nucleoside with different dicarbonyl compounds. In these…”
Get full text

Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding by Bonache, M Angeles, Alaimo, Alessandro, Malo, Covadonga, Millet, Oscar, Villarroel, Alvaro, González-Muñiz, Rosario

“…The recombinant Kv7.2 calmodulin (CaM) binding site (Q2AB CaMBD) shows a high tendency to aggregate, thus complicating biochemical and structural studies. To…”
Get more information

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments by Baeza, José Luis, Bonache, M. Ángeles, García-López, M. Teresa, González-Muñiz, Rosario, Martín-Martínez, Mercedes

“…Conveniently substituted 2-alkyl-2-carboxyazetidine amino acids have been incorporated into NGF and NT3 tetrapeptide sequences to investigate their utility as…”
Get full text

β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure–Activity Relationships and Antiallodynic Activity by Martín-Escura, Cristina, Bonache, M. Ángeles, Medina, Jessy A., Medina-Peris, Alicia, De Andrés-López, Jorge, González-Rodríguez, Sara, Kerselaers, Sara, Fernández-Ballester, Gregorio, Voets, Thomas, Ferrer-Montiel, Antonio, Fernández-Carvajal, Asia, González-Muñiz, Rosario

“…The protein transient receptor potential melastatin type 8 (TRPM8), a non-selective, calcium (Ca2+)-permeable ion channel is implicated in several pathological…”
Get full text

Disrupting VEGF–VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment by Balsera, Beatriz, Bonache, M., Reille-Seroussi, Marie, Gagey-Eilstein, Nathalie, Vidal, Michel, González-Muñiz, Rosario, Pérez de Vega, María

“…The interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGFR) has important implications in angiogenesis and cancer, which moved…”
Get full text

Old Molecules for New Receptors: Trp(Nps) Dipeptide Derivatives as Vanilloid TRPV1 Channel Blockers by Bonache, M. Angeles, García-Martínez, Carolina, García de Diego, Laura, Carreño, Cristina, Pérez de Vega, M. Jesús, García-López, M. Teresa, Ferrer-Montiel, Antonio, González-Muñiz, Rosario

“…The transient receptor potential vanilloid member 1 (TRPV1), an integrator of multiple pain‐producing stimuli, is regarded nowadays as an important biological…”
Get full text

DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target by Butrón, Daniel, Zamora-Carreras, Héctor, Devesa, Isabel, Treviño, Miguel A., Abian, Olga, Velázquez-Campoy, Adrián, Bonache, M. Ángeles, Lagartera, Laura, Martín-Martínez, Mercedes, González-Rodríguez, Sara, Baamonde, Ana, Fernández-Carvajal, Asia, Ferrer-Montiel, Antonio, Jiménez, M. Ángeles, González-Muñiz, Rosario

“…[Display omitted] •DD04107 (Pal-EEMQRR-NH2) inhibits α-CGRP exocytotic release.•Ala-scanning indicated that residues E1, M3, Q4 and R6 are crucial for…”
Get full text

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis by Núñez-Villanueva, Diego, Bonache, M. Ángeles, Lozano, Laura, Infantes, Lourdes, Elguero, José, Alkorta, Ibon, García-López, M. Teresa, González-Muñiz, Rosario, Martín-Martínez, Mercedes

“…Enantiopure β‐amino acids represent interesting scaffolds for peptidomimetics, foldamers and bioactive compounds. However, the synthesis of highly substituted…”
Get full text

De Novo Designed Library of Linear Helical Peptides: An Exploratory Tool in the Discovery of Protein–Protein Interaction Modulators by Bonache, M. Ángeles, Balsera, Beatriz, López-Méndez, Blanca, Millet, Oscar, Brancaccio, Diego, Gómez-Monterrey, Isabel, Carotenuto, Alfonso, Pavone, Luigi M, Reille-Seroussi, Marie, Gagey-Eilstein, Nathalie, Vidal, Michel, de la Torre-Martı́nez, Roberto, Fernández-Carvajal, Asia, Ferrer-Montiel, Antonio, García-López, M. Teresa, Martín-Martínez, Mercedes, de Vega, M. Jesús Pérez, González-Muñiz, Rosario

“…Protein–protein interactions (PPIs) have emerged as important targets for pharmaceutical intervention because of their essential role in numerous physiological…”
Get full text

Posttranslationally modified peptides efficiently mimicking neoantigens: A challenge for theragnostics of autoimmune diseases by Nuti, Francesca, Peroni, Elisa, Real-Fernández, Feliciana, Bonache, M. Angeles, Le Chevalier-Isaad, Alexandra, Chelli, Mario, Lubin-Germain, Nadège, Uziel, Jacques, Rovero, Paolo, Lolli, Francesco, Papini, Anna Maria

“…We report the design, synthesis, and immunological evaluation of a series of glycopeptide analogues of the previously described antigenic probe CSF114(Glc),…”
Get full text

Microwave-assisted reaction of glycosylamine with aspartic acid by Real-Fernández, Feliciana, Nuti, Francesca, Bonache, M. Angeles, Boccalini, Marco, Chimichi, Stefano, Chelli, Mario, Papini, Anna Maria

“…The synthesis of N -protected glycosyl amino acids from amines has been investigated and it was found that, under microwave conditions, glycosylamines could be…”
Get full text

IQM-22110, a new selective inhibitor of KChIP3 and its electrophysiological effects on Kv4.3, Kv4.3/KChIP3 and Kv4.3/KChIP2 currents by Socuéllamos, Paula G., de Benito-Bueno, Angela, Ropero, Maria, Diez, Sara, Elizalde, Pablo, Bonache, M. Angeles, Viedma, Carmen, Martín-Martínez, Mercedes, Gutiérrez-Rodríguez, Marta, Valenzuela, Carmen

Get full text

Experimental and theoretical studies on the rearrangement of 2-oxoazepane α,α-amino acids into 2'-oxopiperidine β(2,3,3) -amino acids: an example of intramolecular catalysis by Núñez-Villanueva, Diego, Bonache, M Ángeles, Lozano, Laura, Infantes, Lourdes, Elguero, José, Alkorta, Ibon, García-López, M Teresa, González-Muñiz, Rosario, Martín-Martínez, Mercedes

“…Enantiopure β-amino acids represent interesting scaffolds for peptidomimetics, foldamers and bioactive compounds. However, the synthesis of highly substituted…”
Get full text

Small Library of Triazolyl Polyphenols Correlating Antioxidant Activity and Stability with Number and Position of Hydroxyl Groups by Bonache, M, Moreno-Fernández, Silvia, Miguel, Marta, Sabater-Muñoz, Beatriz, González-Muñiz, Rosario

“…Polyphenolic compounds have attracted much interest because of their antioxidant properties and multiple applications, from food or cosmetic preservatives to…”
Get full text

IQM-22110, a new selective inhibitor of KChIP3 and its electrophysiological effects on K v 4.3, K v 4.3/KChIP3 and K v 4.3/KChIP2 currents by Socuéllamos, Paula G, de Benito-Bueno, Angela, Ropero, Maria, Diez, Sara, Elizalde, Pablo, Bonache, M Angeles, Viedma, Carmen, Martín-Martínez, Mercedes, Gutiérrez-Rodríguez, Marta, Valenzuela, Carmen

Get full text

β-Lactams derived from phenylalanine and homologues: effects of the distance between the aromatic rings and the α-stereogenic reactive center on the memory of chirality by Bonache, M. Angeles, Cativiela, Carlos, García-López, M. Teresa, González-Muñiz, Rosario

“…The enantioselectivity in the base-promoted cyclization of N-chloroacetyl derivatives of Phe, Phg, and Hph is dependent on the side-chain length, with the best…”
Get full text