Risk assessment of in vitro cytotoxicity, antioxidant and antimicrobial activities of Mentha piperita L. essential oil

Risk assessment of in vitro cytotoxicity, antioxidant and antimicrobial activities of Mentha piperita L. essential oil

The objective of this study was to determine the chemical composition as well as antioxidant, antibacterial, and cytotoxic properties of the essential oil of Mentha piperita L. (peppermint). Fifteen chemical constituents were identified in the essential oil, for a total of 99.99% of the compounds. T...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Vol. 85; no. 6; pp. 230 - 242
Main Authors: Silva, W. M. F., Bona, N. P., Pedra, N. S., Cunha, K. F. Da, Fiorentini, A. M., Stefanello, F. M., Zavareze, E. R., Dias, A. R. G.
Format: Journal Article
Language:English
Published: England Taylor & Francis 19-03-2022
Taylor & Francis Ltd
Subjects:
Anti-Bacterial Agents - pharmacology
Anticancer properties
Antimicrobial activity
Antimicrobial agents
Antioxidants
Antioxidants - pharmacology
Antitumor activity
Bacteria
biological activity
Cell viability
Chemical composition
Cytotoxicity
Essential oils
Glioma cells
Gram-positive bacteria
HaCaT Cells
human epidermal keratinocyte
Humans
Listeria
Listeria monocytogenes
Listeria monocytogenes - drug effects
Mentha piperita
Mentha piperita - chemistry
Mentha piperita - toxicity
menthol
Microbial Sensitivity Tests
Minimum inhibitory concentration
Oils & fats
Oils, Volatile - pharmacology
Oils, Volatile - toxicity
Peppermint
Plant Extracts - pharmacology
Plant Oils - chemistry
Plant Oils - pharmacology
Plant Oils - toxicity
Risk Assessment
Staphylococcus aureus
Staphylococcus aureus - drug effects
Sulfonic acid
Toxicity
Cytotoxicity
menthol
biological activity
human epidermal keratinocyte
Staphylococcus aureus
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Summary:The objective of this study was to determine the chemical composition as well as antioxidant, antibacterial, and cytotoxic properties of the essential oil of Mentha piperita L. (peppermint). Fifteen chemical constituents were identified in the essential oil, for a total of 99.99% of the compounds. The essential oil exhibited antimicrobial activity against two Gram-positive bacteria Staphylococcus aureus and Listeria monocytogenes. The minimum inhibitory concentration (MIC) of essential oil of Mentha piperita L. for Staphylococcus aureus and Listeria monocytogenes was 1.84 μg/ml, whereas the minimum bactericidal concentration (MBC) values were 3.7 and 7.43 μg/ml, respectively. The oil displayed potent antioxidant activity inhibiting up to approximately73% of 2,2ʹ-azinothiobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals. In the cytotoxicity assay, the highest essential oil concentration (100 μg/ml) resulted in viability of approximately 90% human epidermal keratinocyte (HaCaT) cells. With respect to antitumor activity in C6 rat glioma cells, there was significant reduction in cell viability: 56-74% in 24 hr, and 71-77% in 48 hr. Data suggest that in presence of the essential oil of Mentha piperita L. antioxidant, antibacterial, antitumor and non-cytotoxic properties were noted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287394.2021.1999875