Search Results - "Bomsel, Morgane"

Editorial: Mucosal immunity to HIV and SARS-CoV-2 infection and vaccination by Bomsel, Morgane, Lopalco, Lucia

Get full text

Calcitonin Gene-Related Peptide Induces HIV-1 Proteasomal Degradation in Mucosal Langerhans Cells by Bomsel, Morgane, Ganor, Yonatan

“…The neuroimmune dialogue between peripheral neurons and Langerhans cells (LCs) within mucosal epithelia protects against incoming pathogens. LCs rapidly…”
Get full text

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy by Ganor, Yonatan, Real, Fernando, Sennepin, Alexis, Dutertre, Charles-Antoine, Prevedel, Lisa, Xu, Lin, Tudor, Daniela, Charmeteau, Bénédicte, Couedel-Courteille, Anne, Marion, Sabrina, Zenak, Ali-Redha, Jourdain, Jean-Pierre, Zhou, Zhicheng, Schmitt, Alain, Capron, Claude, Eugenin, Eliseo A, Cheynier, Rémi, Revol, Marc, Cristofari, Sarra, Hosmalin, Anne, Bomsel, Morgane

“…Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment on infection of cellular HIV-1 reservoirs that are not fully…”
Get full text

Editorial: Platelet and megakaryocyte dysfunctions in infectious diseases by Assinger, Alice, Capron, Claude, Real, Fernando, Bomsel, Morgane

Get full text

Antibody Fc-chimerism and effector functions: When IgG takes advantage of IgA by Cottignies-Calamarte, Andréa, Tudor, Daniela, Bomsel, Morgane

“…Recent advances in the development of therapeutic antibodies (Abs) have greatly improved the treatment of otherwise drug-resistant cancers and autoimmune…”
Get full text

Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection by Real, Fernando, Sennepin, Alexis, Ganor, Yonatan, Schmitt, Alain, Bomsel, Morgane

“…During sexual intercourse, HIV-1 crosses epithelial barriers composing the genital mucosa, a poorly understood feature that requires an HIV-1-infected cell…”
Get full text

The Protective HIV-1 Envelope gp41 Antigen P1 Acts as a Mucosal Adjuvant Stimulating the Innate Immunity by Xu, Lin, Tudor, Daniela, Bomsel, Morgane

“…Mucosal nasal vaccine development, although ideal to protect from pathogens invading mucosally, is limited by the lack of specific adjuvant. We recently used…”
Get full text

Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41 by Duchemin, Maxence, Tudor, Daniela, Cottignies-Calamarte, Andréa, Bomsel, Morgane

“…Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and…”
Get full text

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis by Duchemin, Maxence, Khamassi, Marwa, Xu, Lin, Tudor, Daniela, Bomsel, Morgane

“…The protective efficacy of human immunodeficiency virus-1 (HIV-1) antibodies (Abs) remains mostly correlated with their neutralizing activity engaging their…”
Get full text

COVID-19 Lung Pathogenesis in SARS-CoV-2 Autopsy Cases by Valdebenito, Silvana, Bessis, Simon, Annane, Djillali, Lorin de la Grandmaison, Geoffroy, Cramer-Bordé, Elisabeth, Prideaux, Brendan, Eugenin, Eliseo A, Bomsel, Morgane

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health issue. COVID-19 is considered an airway/multi-systemic disease, and…”
Get full text

S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo by Real, Fernando, Zhu, Aiwei, Huang, Boxin, Belmellat, Ania, Sennepin, Alexis, Vogl, Thomas, Ransy, Céline, Revol, Marc, Arrigucci, Riccardo, Lombès, Anne, Roth, Johannes, Gennaro, Maria Laura, Bouillaud, Frédéric, Cristofari, Sarra, Bomsel, Morgane

“…HIV-1 eradication is hindered by viral persistence in cell reservoirs, established not only in circulatory CD4 + T-cells but also in tissue-resident…”
Get full text

Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19 by Zhu, Aiwei, Real, Fernando, Capron, Claude, Rosenberg, Arielle R., Silvin, Aymeric, Dunsmore, Garett, Zhu, Jaja, Cottoignies-Callamarte, Andréa, Massé, Jean-Marc, Moine, Pierre, Bessis, Simon, Godement, Mathieu, Geri, Guillaume, Chiche, Jean-Daniel, Valdebenito, Silvana, Belouzard, Sandrine, Dubuisson, Jean, Lorin de la Grandmaison, Geoffroy, Chevret, Sylvie, Ginhoux, Florent, Eugenin, Eliseo A., Annane, Djillali, Bordé, Elisabeth Cramer, Bomsel, Morgane

“…SARS-CoV-2, although not being a circulatory virus, spread from the respiratory tract resulting in multiorgan failures and thrombotic complications, the…”
Get full text

The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals by Khamassi, Marwa, Xu, Lin, Rey, Julien, Duchemin, Maxence, Bouceba, Tahar, Tuffery, Pierre, Tudor, Daniela, Bomsel, Morgane

“…The antibody molecule comprises a variable domain conferring antigen specificity and affinity distinct from the heavy chain constant (CH) domains dictating…”
Get full text

Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier by Bomsel, Morgane

“…Contact between various epithelial cell lines and HIV chronically infected mononuclear cell lines results in a massive and rapid budding of HIV virions toward…”
Get full text

Isotype modulates epitope specificity, affinity, and antiviral activities of anti–HIV-1 human broadly neutralizing 2F5 antibody by Tudor, Daniela, Yu, Huifeng, Maupetit, Julien, Drillet, Anne-Sophie, Bouceba, Tahar, Schwartz-Cornil, Isabelle, Lopalco, Lucia, Tuffery, Pierre, Bomsel, Morgane

“…The constant heavy chain (CH1) domain affects antibody affinity and fine specificity, challenging the paradigm that only variable regions contribute to antigen…”
Get full text

Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes by Leroux-Roels, Geert, Maes, Cathy, Clement, Frédéric, van Engelenburg, Frank, van den Dobbelsteen, Marieke, Adler, Michael, Amacker, Mario, Lopalco, Lucia, Bomsel, Morgane, Chalifour, Anick, Fleury, Sylvain

“…Mucosal antibodies harboring various antiviral activities may best protect mucosal surfaces against early HIV-1 entry at mucosal sites and they should be…”
Get full text

HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4 + T-Cell Profile by Zhu, Aiwei, Real, Fernando, Zhu, Jaja, Greffe, Ségolène, de Truchis, Pierre, Rouveix, Elisabeth, Bomsel, Morgane, Capron, Claude

“…Immunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful…”
Get full text

IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates by Logerot, Sandrine, Figueiredo-Morgado, Suzanne, Charmeteau-de-Muylder, Bénédicte, Sandouk, Abdelkader, Drillet-Dangeard, Anne-Sophie, Bomsel, Morgane, Bourgault-Villada, Isabelle, Couëdel-Courteille, Anne, Cheynier, Rémi, Rancez, Magali

“…Mucosal immune responses are crucial in protecting against pathogens entering through mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal…”
Get full text

Protocol to detect infectious SARS-CoV-2 at low levels using in situ hybridization techniques by Cottignies-Calamarte, Andréa, He, Feifan, Zhu, Aiwei, Real, Fernando, Bomsel, Morgane

“…Low and persistent levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA/protein/virus can be detected in clinical samples months after…”
Get full text

The Human Penis Is a Genuine Immunological Effector Site by Sennepin, Alexis, Real, Fernando, Duvivier, Marine, Ganor, Yonatan, Henry, Sonia, Damotte, Diane, Revol, Marc, Cristofari, Sonia, Bomsel, Morgane

“…The human penis is a main portal of entry for numerous pathogens, and vaccines able to control resulting infections locally are highly desirable. However, in…”
Get full text