Search Results - "Bommer, Guido"

MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells by Ji, Qing, Hao, Xinbao, Zhang, Min, Tang, Wenhua, Yang, Meng, Li, Ling, Xiang, Debing, Desano, Jeffrey T, Bommer, Guido T, Fan, Daiming, Fearon, Eric R, Lawrence, Theodore S, Xu, Liang

“…MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell…”
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Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis by Bommer, Guido T., Van Schaftingen, Emile, Veiga-da-Cunha, Maria

“…Hundreds of metabolic enzymes work together smoothly in a cell. These enzymes are highly specific. Nevertheless, under physiological conditions, many perform…”
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SUZ domain–containing proteins have multiple effects on nonsense-mediated decay target transcripts by Halbout, Mathias, Bury, Marina, Hanet, Aoife, Gerin, Isabelle, Graff, Julie, Killian, Theodore, Gatto, Laurent, Vertommen, Didier, Bommer, Guido T.

“…Many transcripts are targeted by nonsense-mediated decay (NMD), leading to their degradation and the inhibition of their translation. We found that the protein…”
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Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite by Heremans, Isaac P, Caligiore, Francesco, Gerin, Isabelle, Bury, Marina, Lutz, Marilena, Graff, Julie, Stroobant, Vincent, Vertommen, Didier, Teleman, Aurelio A, Van Schaftingen, Emile, Bommer, Guido T

“…Cells are continuously exposed to potentially dangerous compounds. Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases…”
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Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation by Gerin, Isabelle, Clerbaux, Laure-Alix, Haumont, Olivier, Lanthier, Nicolas, Das, Arun K., Burant, Charles F., Leclercq, Isabelle A., MacDougald, Ormond A., Bommer, Guido T.

“…The regulation of synthesis, degradation, and distribution of lipids is crucial for homeostasis of organisms and cells. The sterol regulatory element-binding…”
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Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency by Veiga-da-Cunha, Maria, Chevalier, Nathalie, Stephenne, Xavier, Defour, Jean-Philippe, Paczia, Nicole, Ferster, Alina, Achouri, Younes, Dewulf, Joseph P., Linster, Carole L., Bommer, Guido T., Van Schaftingen, Emile

“…Neutropenia represents an important problem in patients with genetic deficiency in either the glucose-6-phosphate transporter of the endoplasmic reticulum…”
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Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus by Bommer, Guido T., MacDougald, Ormond A.

“…The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved…”
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The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA by Dewulf, Joseph P, Gerin, Isabelle, Rider, Mark H, Veiga-da-Cunha, Maria, Van Schaftingen, Emile, Bommer, Guido T

“…Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be…”
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ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism by Dewulf, Joseph P., Paquay, Stéphanie, Marbaix, Etienne, Achouri, Younès, Van Schaftingen, Emile, Bommer, Guido T.

“…The cytosolic enzyme ethylmalonyl-CoA decarboxylase (ECHDC1) decarboxylates ethyl- or methyl-malonyl-CoA, two side products of acetyl-CoA carboxylase. These…”
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NAT6 acetylates the N‐terminus of different forms of actin by Wiame, Elsa, Tahay, Gaëlle, Tyteca, Donatienne, Vertommen, Didier, Stroobant, Vincent, Bommer, Guido T., Van Schaftingen, Emile

“…All forms of mammalian actin comprise at their N‐terminus a negatively charged region consisting of an N‐acetylated aspartate or glutamate followed by two or…”
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Roles for miRNA-378/378 in adipocyte gene expression and lipogenesis by Gerin, Isabelle, Bommer, Guido T, McCoin, Colin S, Sousa, Kyle M, Krishnan, Venkatesh, MacDougald, Ormond A

“…In this study, we explored the roles of microRNAs in adipocyte differentiation and metabolism. We first knocked down Argonaute2 (Ago2), a key enzyme in the…”
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Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19 by Dewulf, Joseph P., Martin, Manon, Marie, Sandrine, Oguz, Fabie, Belkhir, Leila, De Greef, Julien, Yombi, Jean Cyr, Wittebole, Xavier, Laterre, Pierre-François, Jadoul, Michel, Gatto, Laurent, Bommer, Guido T., Morelle, Johann

“…SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for…”
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ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan by Gerin, Isabelle, Ury, Benoît, Breloy, Isabelle, Bouchet-Seraphin, Céline, Bolsée, Jennifer, Halbout, Mathias, Graff, Julie, Vertommen, Didier, Muccioli, Giulio G., Seta, Nathalie, Cuisset, Jean-Marie, Dabaj, Ivana, Quijano-Roy, Susana, Grahn, Ammi, Van Schaftingen, Emile, Bommer, Guido T.

“…Mutations in genes required for the glycosylation of α-dystroglycan lead to muscle and brain diseases known as dystroglycanopathies. However, the precise…”
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The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi by Ury, Benoît, Potelle, Sven, Caligiore, Francesco, Whorton, Matthew R., Bommer, Guido T.

“…The glycoprotein α-dystroglycan helps to link the intracellular cytoskeleton to the extracellular matrix. A unique glycan structure attached to this protein is…”
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p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes by Bommer, Guido T., Gerin, Isabelle, Feng, Ying, Kaczorowski, Andrew J., Kuick, Rork, Love, Robert E., Zhai, Yali, Giordano, Thomas J., Qin, Zhaohui S., Moore, Bethany B., MacDougald, Ormond A., Cho, Kathleen R., Fearon, Eric R.

“…In response to varied cell stress signals, the p53 tumor-suppressor protein activates a multitude of genes encoding proteins with functions in cell-cycle…”
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The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases by Kentache, Takfarinas, Thabault, Léopold, Peracchi, Alessio, Frédérick, Raphaël, Bommer, Guido T, Van Schaftingen, Emile

“…Homologues of the putative dehydrogenase YjhC are found in operons involved in the metabolism of N-acetylneuraminate (Neu5Ac) or related compounds. We observed…”
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Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase by Gerin, Isabelle, Noël, Gaëtane, Bolsée, Jennifer, Haumont, Olivier, Van Schaftingen, Emile, Bommer, Guido T

“…The p53-induced protein TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is considered to be a F26BPase…”
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Inborn errors of metabolite repair by Veiga‐da‐Cunha, Maria, Van Schaftingen, Emile, Bommer, Guido T.

“…It is traditionally assumed that enzymes of intermediary metabolism are extremely specific and that this is sufficient to prevent the production of useless…”
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Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines by Gerin, Isabelle, Bury, Marina, Baldin, Francesca, Graff, Julie, Van Schaftingen, Emile, Bommer, Guido T

“…Repair of a certain type of oxidative DNA damage leads to the release of phosphoglycolate, which is an inhibitor of triose phosphate isomerase and is predicted…”
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Absence of the dolichol synthesis gene DHRSX leads to N-glycosylation defects in Lec5 and Lec9 Chinese hamster ovary cells by Kentache, Takfarinas, Althoff, Charlotte R., Caligiore, Francesco, Souche, Erika, Schulz, Céline, Graff, Julie, Pieters, Eline, Stanley, Pamela, Contessa, Joseph N., Van Schaftingen, Emile, Matthijs, Gert, Foulquier, François, Bommer, Guido T., Wilson, Matthew P.

“…Glycosylation-deficient Chinese hamster ovary cell lines have been instrumental in the discovery of N-glycosylation machinery. Yet, the molecular causes of the…”
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