Search Results - "Bommareddy, Praveen K."

Integrating oncolytic viruses in combination cancer immunotherapy by Bommareddy, Praveen K., Shettigar, Megha, Kaufman, Howard L.

“…Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer–immunity cycle. Oncolytic viruses…”
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Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma by Bommareddy, Praveen K., Zloza, Andrew, Rabkin, Samuel D., Kaufman, Howard L.

“…Successful immunotherapy for melanoma depends on the recruitment of effector CD8 + T cells to the tumor microenvironment. Factors contributing to T cell…”
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Oncolytic Herpes Simplex Virus Encoding IL12 Controls Triple-Negative Breast Cancer Growth and Metastasis by Ghouse, Shanawaz M, Nguyen, Hong-My, Bommareddy, Praveen K, Guz-Montgomery, Kirsten, Saha, Dipongkor

“…Triple-negative breast cancer (TNBC) is a difficult-to-treat disease with high rates of local recurrence, distant metastasis, and poor overall survival with…”
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Oncolytic Viruses-Natural and Genetically Engineered Cancer Immunotherapies by Jhawar, Sachin R, Thandoni, Aditya, Bommareddy, Praveen K, Hassan, Suemair, Kohlhapp, Frederick J, Goyal, Sharad, Schenkel, Jason M, Silk, Ann W, Zloza, Andrew

“…There has long been interest in innovating an approach by which tumor cells can be selectively and specifically targeted and destroyed. The discovery of…”
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Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1 by Thomas, Suzanne, Kuncheria, Linta, Roulstone, Victoria, Kyula, Joan N, Mansfield, David, Bommareddy, Praveen K, Smith, Henry, Kaufman, Howard L, Harrington, Kevin J, Coffin, Robert S

“…Oncolytic viruses preferentially replicate in tumors as compared to normal tissue and promote immunogenic cell death and induction of host systemic anti-tumor…”
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Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma by Bommareddy, Praveen K., Patel, Anand, Hossain, Saamia, Kaufman, Howard L.

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Two roads for oncolytic immunotherapy development by Kaufman, Howard L, Bommareddy, Praveen K

“…Oncolytic viruses are an emerging class of immunotherapy agents for cancer treatment. In this issue of JITC, Machiels et al. reports early phase data from an…”
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Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival by Bommareddy, Praveen K, Wakimoto, Hiroaki, Martuza, Robert L, Kaufman, Howard L, Rabkin, Samuel D, Saha, Dipongkor

“…BackgroundGlioblastoma (GBM), a highly immunosuppressive and often fatal primary brain tumor, lacks effective treatment options. GBMs contain a subpopulation…”
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Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord by Mende, Michael, Fletcher, Emily V., Belluardo, Josephine L., Pierce, Joseph P., Bommareddy, Praveen K., Weinrich, Jarret A., Kabir, Zeeba D., Schierberl, Kathryn C., Pagiazitis, John G., Mendelsohn, Alana I., Francesconi, Anna, Edwards, Robert H., Milner, Teresa A., Rajadhyaksha, Anjali M., van Roessel, Peter J., Mentis, George Z., Kaltschmidt, Julia A.

“…Circuit function in the CNS relies on the balanced interplay of excitatory and inhibitory synaptic signaling. How neuronal activity influences synaptic…”
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A Water-Soluble Antibiotic in Rhubarb Stalk Shows an Unusual Pattern of Multiple Zones of Inhibition and Preferentially Kills Slow-Growing Bacteria by Bhattacharjee, Mrinal K., Bommareddy, Praveen K., DePass, Anthony L.

“…Organic extract of Rhubarb (Rheum officinale) roots is known to have several medicinal uses. However, not much research has been done with the rhubarb stalk…”
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Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer by Newman, Jenna H., Augeri, David J., NeMoyer, Rachel, Malhotra, Jyoti, Langenfeld, Elaine, Chesson, Charles B., Dobias, Natalie S., Lee, Michael J., Tarabichi, Saeed, Jhawar, Sachin R., Bommareddy, Praveen K., Marshall, Sh’Rae, Sadimin, Evita T., Kerrigan, John E., Goedken, Michael, Minerowicz, Christine, Jabbour, Salma K., Li, Shengguo, Carayannopolous, Mary O., Zloza, Andrew, Langenfeld, John

“…BMP receptor inhibitors induce death of cancer cells through the downregulation of antiapoptotic proteins XIAP, pTAK1, and Id1-Id3. However, the current most…”
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Oncolytic Herpes Simplex Viruses as a Paradigm for the Treatment of Cancer by Bommareddy, Praveen K, Peters, Cole, Saha, Dipongkor, Rabkin, Samuel D, Kaufman, Howard L

“…Oncolytic viruses are native or modified viruses that directly kill tumor cells but spare normal tissue and promote host antitumor immunity. Recently, an…”
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Triple threat to cancer: rationale for combining oncolytic viruses, MEK inhibitors, and immune checkpoint blockade by Bommareddy, Praveen K., Rabkin, Samuel D., Kaufman, Howard L.

“…In a recent edition of Science Translational Medicine, we identified an enhanced therapeutic activity when talimogene laherparepvec (T-VEC) was combined with…”
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A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry by Zhang, Juliet, Weinrich, Jarret A.P., Russ, Jeffrey B., Comer, John D., Bommareddy, Praveen K., DiCasoli, Richard J., Wright, Christopher V.E., Li, Yuqing, van Roessel, Peter J., Kaltschmidt, Julia A.

“…Spinal interneurons are critical modulators of motor circuit function. In the dorsal spinal cord, a set of interneurons called GABApre presynaptically…”
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Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancer by Jhawar, Sachin R, Wang, Shang-Jui, Thandoni, Aditya, Bommareddy, Praveen K, Newman, Jenna H, Giurini, Eileena F, Marzo, Amanda L, Kuzel, Timothy M, Gupta, Vineet, Reiser, Jochen, Daniels, Preston, Schiff, Devora, Mitchell, Darrion, LeBoeuf, Nicole R, Simmons, Christopher, Goyal, Sharad, Lasfar, Ahmed, Guevara-Patino, Jose A, Haffty, Bruce G, Kaufman, Howard L, Silk, Ann W, Zloza, Andrew

“…BackgroundImmunotherapies are becoming front-line treatments for many advanced cancers, and combinations of two or more therapies are beginning to be…”
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Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma by Bommareddy, Praveen K., Patel, Anand, Hossain, Saamia, Kaufman, Howard L.

“…Many mammalian viruses have properties that can be commandeered for the treatment of cancer. These characteristics include preferential infection and…”
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High-Dose Ipilimumab and High-Dose Interleukin-2 for Patients With Advanced Melanoma by Silk, Ann W, Kaufman, Howard L, Curti, Brendan, Mehnert, Janice M, Margolin, Kim, McDermott, David, Clark, Joseph, Newman, Jenna, Bommareddy, Praveen K, Denzin, Lisa, Najmi, Saltanat, Haider, Azra, Shih, Weichung, Kane, Michael P, Zloza, Andrew

“…High-dose ipilimumab (IPI) and high-dose interleukin-2 (IL-2) are approved agents for metastatic melanoma, but the efficacy and safety of the combination are…”
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MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation by Bommareddy, Praveen K, Aspromonte, Salvatore, Zloza, Andrew, Rabkin, Samuel D, Kaufman, Howard L

“…Melanoma is an aggressive cutaneous malignancy, but advances over the past decade have resulted in multiple new therapeutic options, including molecularly…”
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Optimal timing of PD-1 blockade in combination with oncolytic virus therapy by Nguyen, Hong-My, Bommareddy, Praveen K., Silk, Ann W., Saha, Dipongkor

“…Anti-PD-1 and oncolytic viruses (OVs) have non-overlapping anti-tumor mechanisms, since each agent works at different steps of the cancer-immunity cycle…”
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Multi-parametric flow cytometry staining procedure for analyzing tumor-infiltrating immune cells following oncolytic herpes simplex virus immunotherapy in intracranial glioblastoma by Bommareddy, Praveen K, Lowe, Devin B, Kaufman, Howard L, Rabkin, Samuel D, Saha, Dipongkor

“…Multi-color flow cytometry is a standard laboratory protocol, which is regularly used to analyze tumor-infiltrating immune cell subsets. Oncolytic herpes…”
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