Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4⁺ T cell activation in vitro

Dendritic cells (DCs) have been described as initiators and modulators of the immune response. Recently we have shown a predominant production of interleukin-10 cytokine, low levels of interferon-γ and inefficient T cell proliferation in patients with severe forms of chromoblastomycosis. Chromoblast...

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Bibliographic Details
Published in:	Clinical and experimental immunology Vol. 156; no. 1; pp. 117 - 125
Main Authors:	Sousa, M. Glória, Ghosn, E. Eid Bou, Nascimento, R. Ciciro, Bomfim, G. Facchioli, Noal, V, Santiago, K, de Maria Pedrozo e Silva Azevedo, C, Marques, S. Garcia, Gonçalves, A. Guedes, de Castro Lima Santos, D. Wagner, Criado, P. Ricardo, Costa Martins, J. Eduardo, Almeida, S. Rogerio
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-04-2009 Blackwell Publishing Ltd Blackwell Blackwell Science Inc
Subjects:	Adult Aged Analytical, structural and metabolic biochemistry Antigens, Fungal - immunology B7-2 Antigen - metabolism Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Cell Proliferation Cells, Cultured Chromoblastomycoses chromoblastomycosis Chromoblastomycosis - immunology Cytokines - biosynthesis Dendritic Cells - immunology Female Fonsecaea pedrosoi Fundamental and applied biological sciences. Psychology HLA-DR Antigens - metabolism Human mycoses Humans IL-10 IL-12 immune regulation Infectious diseases Lymphocyte Activation - immunology Male Medical sciences Middle Aged Mitosporic Fungi - immunology Mycoses Th1 Cells - immunology Th1/Th2 Translation Studies Tropical mycoses Up-Regulation - immunology Human Dendritic cell Skin disease CD4 T lymphocyte Mycosis Monocyte Cytokine Chromoblastomycosis Interleukin 12 Activation Biochemistry Immune regulation Thl/Th2 IL-12 In vitro IL-10 Infection Antigen presenting cell Interleukin 10 T-Lymphocyte Th2 lymphocyte DC
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Summary:	Dendritic cells (DCs) have been described as initiators and modulators of the immune response. Recently we have shown a predominant production of interleukin-10 cytokine, low levels of interferon-γ and inefficient T cell proliferation in patients with severe forms of chromoblastomycosis. Chromoblastomycosis starts with subcutaneous inoculation of Fonsecaea pedrosoi into tissue where DCs are the first line of defence against this microorganism. In the present study, the interaction of F. pedrosoi and DCs obtained from patients with chromoblastomycosis was investigated. Our results showed that DCs from patients exhibited an increased expression of human leucocyte antigen D-related (HLA-DR) and co-stimulatory molecules. In the presence of conidia, the expression of HLA-DR and CD86 was up-regulated by DCs from patients and controls. Finally, we demonstrate the reversal of antigen-specific anergy and a T helper type 1 response mediated by DCs incubated with F. pedrosoi conidea.
Bibliography:	http://dx.doi.org/10.1111/j.1365-2249.2008.03870.x ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-9104 1365-2249
DOI:	10.1111/j.1365-2249.2008.03870.x