Search Results - "Bombick, Betsy"

Development, qualification, validation and application of the Ames test using a VITROCELL® VC10® smoke exposure system by Fowler, Kathy, Fields, Wanda, Hargreaves, Victoria, Reeve, Lesley, Bombick, Betsy

“…[Display omitted] •Smoke-induced mutagenicity at air agar interface was developed and validated.•The VITROCELL® VC10® system was validated by equipment…”
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Distinct regulatory profiles of interleukins and chemokines in response to cigarette smoke condensate in normal human bronchial epithelial (NHBE) cells by Parsanejad, Reza, Fields, Wanda R, Steichen, Thomas J, Bombick, Betsy R, Doolittle, David J

“…Bronchial epithelium is frequently exposed to air pollutants, and it is hypothesized that these cells elicit inflammatory responses as early elements in…”
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A summary of toxicological and chemical data relevant to the evaluation of cast sheet tobacco by Potts, Ryan J., Bombick, Betsy R., Meckley, Daniel R., Ayres, Paul H., Pence, Deborah H.

“…A tiered testing strategy based on a comparative chemical and biological testing program has been developed to evaluate the potential of tobacco processes,…”
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THE TIME COURSE OF EXPRESSION OF GENES INVOLVED IN SPECIFIC PATHWAYS IN NORMAL HUMAN BRONCHIAL EPITHELIAL CELLS FOLLOWING EXPOSURE TO CIGARETTE SMOKE by Parsanejad, Reza, Fields, Wanda R., Morgan, Walter T., Bombick, Betsy R., Doolittle, David J.

“…This study was conducted to determine the time course of gene expression associated with specific signaling pathways in normal human bronchial epithelial…”
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Toxicological evaluation of cigarettes with two banded cigarette paper technologies by Theophilus, Eugenia H., Pence, Deborah H., Meckley, Daniel R., Keith Shreve, W., Ayres, Paul H., Bombick, Betsy R., Borgerding, Michael F., Garner, Charles D., Swauger, James E.

“…A tiered testing strategy has been employed to evaluate the potential of tobacco processes, ingredients, or technological developments to change the biological…”
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Toxicological Evaluation of Honey as an Ingredient Added to Cigarette Tobacco by Stavanja, Mari, Ayres, Paul, Meckley, Daniel, Bombick, Betsy, Pence, Deborah, Borgerding, Michael, Morton, Michael, Mosberg, Arnold, Swauger, James

“…A tiered testing strategy has been developed to evaluate the potential for new ingredients, tobacco processes, and technological developments to increase or…”
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Genotoxicity evaluation of tobacco and nicotine delivery products: Part Two. In vitro micronucleus assay by Thorne, David, Leverette, Robert, Breheny, Damien, Lloyd, Mel, McEnaney, Stephen, Whitwell, James, Clements, Julie, Bombick, Betsy, Gaça, Marianna

“…In this study, a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F Kentucky reference cigarette using the in…”
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Development, qualification, validation and application of the neutral red uptake assay in Chinese Hamster Ovary (CHO) cells using a VITROCELL® VC10® smoke exposure system by Fields, Wanda, Fowler, Kathy, Hargreaves, Victoria, Reeve, Lesley, Bombick, Betsy

“…Cytotoxicity assessment of combustible tobacco products by neutral red uptake (NRU) has historically used total particulate matter (TPM) or solvent captured…”
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Toxicological evaluation of expanded shredded tobacco stems by Theophilus, Eugenia H., Pence, Deborah H., Meckley, Daniel R., Higuchi, Mark A., Bombick, Betsy R., Borgerding, Michael F., Ayres, Paul H., Swauger, James E.

“…A tiered testing strategy has been developed to evaluate the potential of tobacco processes, ingredients, or technological developments to change the…”
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Genotoxicity evaluation of tobacco and nicotine delivery products: Part One. Mouse lymphoma assay by Thorne, David, Leverette, Robert, Breheny, Damien, Lloyd, Mel, McEnaney, Stephen, Whitwell, James, Clements, Julie, Bombick, Betsy, Gaca, Marianna

“…Conduct of the mouse lymphoma assay (MLA) is underpinned by Organisation for Economic Co-operation and Development (OECD) Test Guideline 490 and International…”
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Toxicological evaluation of dry ice expanded tobacco by Theophilus, Eugenia H., Poindexter, Dale B., Meckley, Daniel R., Bombick, Betsy R., Borgerding, Michael F., Higuchi, Mark A., Ayres, Paul H., Morton, Michael J., Mosberg, Arnold T., Swauger, James E.

“…A tiered testing strategy has been developed to evaluate the potential of tobacco processes, ingredients, or technological developments to change the…”
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Toxicological evaluation of propane expanded tobacco by Theophilus, Eugenia H., Bombick, Betsy R., Meckley, Daniel R., Higuchi, Mark A., Borgerding, Michael F., Morton, Michael J., Mosberg, Arnold T., Swauger, James E.

“…A tiered testing strategy has been developed to evaluate the potential for tobacco processes, ingredients, and other technological developments to increase or…”
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Development of a quantitative method for assessment of dose in in vitro evaluations using a VITROCELL® VC10® smoke exposure system by Keyser, Brian M., Leverette, Robert, Fowler, Kathy, Fields, Wanda, Hargreaves, Victoria, Reeve, Lesley, Bombick, Betsy

“…The assessment of potential cytotoxicity or genotoxicity of combustible tobacco products has historically been performed using partitioned exposures (i.e…”
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Relationship between FTC ‘tar’ and urine mutagenicity in smokers of tobacco-burning or Eclipse cigarettes by Bowman, Denise L, Smith, Carr J, Bombick, Betsy R, Avalos, Jerry T, Davis, Riley A, Morgan, Walter T, Doolittle, David J

“…The US Federal Trade Commission (FTC) classifies domestic cigarettes into one of three ‘tar’ categories based on ‘tar’ and nicotine levels. The objective of…”
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VUSE electronic cigarette aerosol chemistry and cytotoxicity by Theophilus, Eugenia, Potts, Ryan, Fowler, Kathy, Fields, Wanda, Bombick, Betsy

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Evaluation of cytotoxicity of different tobacco product preparations by Arimilli, Subhashini, Damratoski, Brad E., Bombick, Betsy, Borgerding, Michael F., Prasad, G.L.

“…► We reported the cellular responses to treatment with cigarette smoke and smokeless TPPs in short-term cell cultures. ► Combustible TPPS induced more DNA…”
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Human Aortic Endothelial Cells Respond to Shear Flow in Well-Plate Microfluidic Devices by Makwana, Om, Flockton, Hannah, Watters, Gary P., Nisar, Rizwan, Smith, Gina A., Fields, Wanda, Bombick, Betsy

“…Although chronic progressive cardiovascular diseases such as atherosclerosis are often challenging to fully model in vitro, it has been shown that certain in…”
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Abstract 1693: Assessment of Nrf2 luciferase reporter assay and heme oxygenase expression as models of oxidative stress in in vitro cultures of lung cells exposed to cigarette smoke condensate by Fields, Wanda R., Liedtke, Wolfgang, Li, Jinju, Bombick, Betsy

“…Abstract The Nrf2 signaling pathway is an important regulator associated with oxidative stress, xenobiotic metabolism, DNA damage and anti-inflammatory…”
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Assessment of In Vitro COPD Models for Tobacco Regulatory Science: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use by Behrsing, Holger, Raabe, Hans, Manuppello, Joseph, Bombick, Betsy, Curren, Rodger, Sullivan, Kristie, Sethi, Sanjay, Phipps, Richard, Tesfaigzi, Yohannes, Yan, Sherwin, D'Ruiz, Carl, Tarran, Robert, Constant, Samuel, Phillips, Gary, Gaça, Marianna, Hayden, Patrick, Cao, Xuefei, Mathis, Carole, Hoeng, Julia, Braun, Armin, Hill, Erin

“…The Family Smoking Prevention and Tobacco Control Act of 2009 established the Food and Drug Administration Center for Tobacco Products (FDA-CTP), and gave it…”
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Trace Analysis of Mutagenic Heterocyclic Aromatic Amines in Cigarette Smoke Condensate and its Base Fractions via Silylation-GC-MS by Liu, S, Taylor, LT, Borgerding, MF, Coleman, WM, Bombick, BR

“…Among the more than 5000 chemicals reported in cigarette smoke condensate (CSC), heterocyclic aromatic amines (HAAs) are considered to be a contributor to…”
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