Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers

The aim of our study was to evaluate the effect of a standardized formulation of a polyphenolic extract of grapes (Leucoselect-Phytosome [LP]) on low-density lipoprotein (LDL) susceptibility to oxidation in a group of heavy smokers. A randomized, double-blind, crossover study was undertaken in 24 he...

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Bibliographic Details
Published in:	Metabolism, clinical and experimental Vol. 52; no. 10; pp. 1250 - 1257
Main Authors:	Vigna, Giovanni B, Costantini, Fabrizio, Aldini, Giancarlo, Carini, Marina, Catapano, Alberico, Schena, Fabio, Tangerini, Arianna, Zanca, Rosanna, Bombardelli, Egidio, Morazzoni, Paolo, Mezzetti, Andrea, Fellin, Renato, Maffei Facino, Roberto
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-10-2003 Elsevier
Subjects:	Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - pharmacology beta Carotene - blood Biflavonoids Biological and medical sciences Carotenoids - blood Catechin - administration & dosage Catechin - chemistry Catechin - pharmacology Cholesterol, HDL - blood Cholesterol, LDL - blood Cross-Over Studies Disorders of blood lipids. Hyperlipoproteinemia Double-Blind Method Humans Lycopene Male Medical sciences Metabolic diseases Middle Aged Oxidation-Reduction Oxidative Stress Plant Extracts - pharmacology Proanthocyanidins Smoking - blood Time Factors Tocopherols - blood Treatment Outcome Triglycerides - blood Vitamin A - blood Vitis Human Seeds Healthy subject Treatment efficiency Density Lipoprotein LDL Polyphenol Randomization Smoker Grape Double blind study Oxidation Phytotherapy
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Summary:	The aim of our study was to evaluate the effect of a standardized formulation of a polyphenolic extract of grapes (Leucoselect-Phytosome [LP]) on low-density lipoprotein (LDL) susceptibility to oxidation in a group of heavy smokers. A randomized, double-blind, crossover study was undertaken in 24 healthy male heavy smokers, aged ≥ 50 years. Enrolled subjects were given 2 capsules twice daily for 4 weeks (phase 1). Each capsule contained 75 mg of a grape procyanidin extracts and soy-phosphatidlcholine or placebo consisiting of 75 mg lactose and soy-phosphatidlcholine. A wash out period of 3 weeks was then followed by 4 weeks of the opposite treatment (phase 2). Blood samples were taken at baseline and at the end of each phase and assayed for plasma lipids and LDL susceptibility to oxidation. Compliance was good, and no adverse effects were recorded. Subjects did not show significant modification of total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) and LDL-C during LP treatment. Among oxidative indices, thiobarbituric acid reactive substances (TBARS) concentration was significantly reduced in subjects taking LP (−14.7% ± 21.1% v +5.0% ± 18.1%, P < .01), and the lag phase prolonged (+15.4% ± 24.4% v −0.1% ± 16.0%, P < .05) compared with placebo and basal values. The antioxidant potential of grape seed extract polyphenols may prove effective in a model of oxidative stress (smoking); however more investigational data are needed before use in wider clinical settings.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0026-0495 1532-8600
DOI:	10.1016/S0026-0495(03)00192-6