Search Results - "Bom, David"

Thermogravimetric Analysis of the Oxidation of Multiwalled Carbon Nanotubes:  Evidence for the Role of Defect Sites in Carbon Nanotube Chemistry by Bom, David, Andrews, Rodney, Jacques, David, Anthony, John, Chen, Bailin, Meier, Mark S, Selegue, John P

“…Thermogravimetric analysis (TGA) has demonstrated that multiwalled nanotubes (MWNTs) annealed at 2200 to 2800 °C are more air stable than as-produced MWNTs,…”
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Monitoring of Total Type II Pyrethroid Pesticides in Citrus Oils and Water by Converting to a Common Product 3-Phenoxybenzoic Acid by McCoy, Mark R, Yang, Zheng, Fu, Xun, Ahn, Ki Chang, Gee, Shirley J, Bom, David C, Zhong, Ping, Chang, Dan, Hammock, Bruce D

“…Pyrethroids are a class of insecticides that are becoming increasingly popular in agricultural and home use applications. Sensitive assays for pyrethroid…”
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The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors by Tumey, L. Nathan, Bom, David, Huck, Bayard, Gleason, Elizabeth, Wang, Jianmin, Silver, Daniel, Brunden, Kurt, Boozer, Sherry, Rundlett, Stephen, Sherf, Bruce, Murphy, Steven, Dent, Tom, Leventhal, Christina, Bailey, Andrew, Harrington, John, Bennani, Youssef L.

“…We describe the identification and SAR of a series of low nanomolar inhibitors of FEN1, an enzyme involved in DNA repair pathways. These inhibitors have been…”
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A General Synthetic Approach to the (20S)-Camptothecin Family of Antitumor Agents by a Regiocontrolled Cascade Radical Cyclization of Aryl Isonitriles by Josien, Hubert, Ko, Sung-Bo, Bom, David, Curran, Dennis P.

“…The power of radical reactions continues to increase! A cascade radical annulation route now allows perhaps the mildest and most general method for the…”
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The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity by Bom, David, Curran, Dennis P, Kruszewski, Stefan, Zimmer, Stephen G, Thompson Strode, J, Kohlhagen, Glenda, Du, Wu, Chavan, Ashok J, Fraley, Kimberly A, Bingcang, Alex L, Latus, Lori J, Pommier, Yves, Burke, Thomas G

“…We describe the rational design and synthesis of B- and A,B-ring-modified camptothecins. The key α-hydroxy-δ-lactone pharmacophore in…”
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Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists by Robarge, Michael J., Bom, David C., Nathan Tumey, L., Varga, Norbert, Gleason, Elizabeth, Silver, Daniel, Song, Jianping, Murphy, Steven M., Ekema, George, Doucette, Chris, Hanniford, Doug, Palmer, Marc, Pawlowski, Gary, Danzig, Joel, Loftus, Margaret, Hunady, Karen, Sherf, Bruce A., Mays, Robert W., Stricker-Krongrad, Alain, Brunden, Kurt R., Harrington, John J., Bennani, Youssef L.

“…The chemoattractant receptor-homologous molecule expressed on T H2 cells (CRTH-2), also found on eosinophils and basophils, is a prostaglandin D 2 receptor…”
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7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents by Josien, Hubert, Bom, David, Curran, Dennis P., Zheng, Yu-Huang, Chou, Ting-Chao

“…The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or…”
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Campthotecin Design and Delivery Approaches for Elevating Anti-Topoisomerase I Activities in Vivo by BURKE, THOMAS G., BOM, DAVID

“…: The camptothecins as a class have exhibited unique dynamics and reactivity in vivo, with respect to both drug hydrolysis and blood protein interactions…”
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A Versatile Prodrug Approach for Liposomal Core-Loading of Water-Insoluble Camptothecin Anticancer Drugs by Liu, Xinli, Lynn, Bert C, Zhang, Junhong, Song, Lin, Bom, David, Du, Wu, Curran, Dennis P, Burke, Thomas G

“…We describe a versatile prodrug strategy for loading the liposomal lumen with water-insoluble camptothecins. The procedure involves conversion of an active…”
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Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities by Bom, David, Curran, Dennis P, Chavan, Ashok J, Kruszewski, Stefan, Zimmer, Stephen G, Fraley, Kimberly A, Burke, Thomas G

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Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo by POLLACK, I. F, ERFF, M, BOM, D, BURKE, T. G, STRODE, J. T, CURRAN, D. P

“…Although topoisomerase inhibitors, such as camptothecin and topotecan, have been widely used in the treatment of nonglial tumors, their application for gliomas…”
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The Cascade Radical Annulation Approach to New Analogues of Camptothecins: Combinatorial Synthesis of Silatecans and Homosilatecans by CURRAN, DENNIS P., JOSIEN, HUBERT, BOM, DAVID, GABARDA, ANA E., DU, WU

“…: An overview of the cascade radical annulation approach to the camptothecin family of antitumor drugs is presented. This combinatorial synthetic approach…”
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Implementation of a radical cascade cyclization in drug discovery: Total synthesis of the silatecans and homosilatecans by Bom, David Christian

“…The camptothecin family of antineoplastic agents have cured a wide range of tumors both in vitro and in vivo. Unfortunately, the success of these drugs in…”
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Implementation of a radical cascade cyclization in drug discovery: Total synthesis of the silatecans and homosilatecans by Bom, David Christian

“…The camptothecin family of antineoplastic agents have cured a wide range of tumors both in vitro and in vivo. Unfortunately, the success of these drugs in…”
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The Combinatorial Synthesis of Racemic Homosilatecan Libraries via a Cascade Radical Annulation by DU, WU, GABARDA, ANA E., BOM, DAVID, CURRAN, DENNIS P.

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