Search Results - "Bolton, Marcus J."

Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration by Gouma, Sigrid, Weirick, Madison E, Bolton, Marcus J, Arevalo, Claudia P, Goodwin, Eileen C, Anderson, Elizabeth M, McAllister, Christopher M, Christensen, Shannon R, Dunbar, Debora, Fiore, Danielle, Brock, Amanda, Weaver, JoEllen, Millar, John, DerOhannessian, Stephanie, Unit, The UPenn Covid Processing, Frank, Ian, Rader, Daniel J, Wherry, E John, Hensley, Scott E

“…Some studies suggest that recent common coronavirus (CCV) infections are associated with reduced COVID-19 severity upon SARS-CoV-2 infection. We completed…”
Get full text

Changes in the Hemagglutinin and Internal Gene Segments Were Needed for Human Seasonal H3 Influenza A Virus to Efficiently Infect and Replicate in Swine by Rajao, Daniela S, Abente, Eugenio J, Powell, Joshua D, Bolton, Marcus J, Gauger, Phillip C, Arruda, Bailey, Anderson, Tavis K, Sutton, Troy C, Perez, Daniel R, Vincent Baker, Amy L

“…The current diversity of influenza A viruses (IAV) circulating in swine is largely a consequence of human-to-swine transmission events and consequent evolution…”
Get full text

Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios by Flannery, Dustin D, Gouma, Sigrid, Dhudasia, Miren B, Mukhopadhyay, Sagori, Pfeifer, Madeline R, Woodford, Emily C, Triebwasser, Jourdan E, Gerber, Jeffrey S, Morris, Jeffrey S, Weirick, Madison E, McAllister, Christopher M, Bolton, Marcus J, Arevalo, Claudia P, Anderson, Elizabeth M, Goodwin, Eileen C, Hensley, Scott E, Puopolo, Karen M

“…Maternally derived antibodies are a key element of neonatal immunity. Understanding the dynamics of maternal antibody responses to severe acute respiratory…”
Get more information

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes by Arevalo, Claudia P, Bolton, Marcus J, Le Sage, Valerie, Ye, Naiqing, Furey, Colleen, Muramatsu, Hiromi, Alameh, Mohamad-Gabriel, Pardi, Norbert, Drapeau, Elizabeth M, Parkhouse, Kaela, Garretson, Tyler, Morris, Jeffrey S, Moncla, Louise H, Tam, Ying K, Fan, Steven H Y, Lakdawala, Seema S, Weissman, Drew, Hensley, Scott E

“…Seasonal influenza vaccines offer little protection against pandemic influenza virus strains. It is difficult to create effective prepandemic vaccines because…”
Get full text

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection by Anderson, Elizabeth M., Goodwin, Eileen C., Verma, Anurag, Arevalo, Claudia P., Bolton, Marcus J., Weirick, Madison E., Gouma, Sigrid, McAllister, Christopher M., Christensen, Shannon R., Weaver, JoEllen, Hicks, Philip, Manzoni, Tomaz B., Oniyide, Oluwatosin, Ramage, Holly, Mathew, Divij, Baxter, Amy E., Oldridge, Derek A., Greenplate, Allison R., Wu, Jennifer E., Alanio, Cécile, D’Andrea, Kurt, Kuthuru, Oliva, Dougherty, Jeanette, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Apostolidis, Sokratis A., Huang, Alex C., Vella, Laura A., Kuri-Cervantes, Leticia, Pampena, M. Betina, Betts, Michael R., Wherry, E. John, Meyer, Nuala J., Cherry, Sara, Bates, Paul, Rader, Daniel J., Hensley, Scott E.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most…”
Get full text

Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies by Arevalo, Claudia P., Le Sage, Valerie, Bolton, Marcus J., Eilola, Theresa, Jones, Jennifer E., Kormuth, Karen A., Nturibi, Eric, Balmaseda, Angel, Gordon, Aubree, Lakdawala, Seema S., Hensley, Scott E.

“…Immunity to influenza viruses can be long-lived, but reinfections with antigenically distinct viral strains and subtypes are common. Reinfections can boost…”
Get full text

Comprehensive mapping of immune perturbations associated with severe COVID-19 by Kuri-Cervantes, Leticia, Pampena, M Betina, Meng, Wenzhao, Rosenfeld, Aaron M, Ittner, Caroline A G, Weisman, Ariel R, Agyekum, Roseline S, Mathew, Divij, Baxter, Amy E, Vella, Laura A, Kuthuru, Oliva, Apostolidis, Sokratis A, Bershaw, Luanne, Dougherty, Jeanette, Greenplate, Allison R, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Gouma, Sigrid, Weirick, Madison E, Arevalo, Claudia P, Bolton, Marcus J, Goodwin, Eileen C, Anderson, Elizabeth M, Hensley, Scott E, Jones, Tiffanie K, Mangalmurti, Nilam S, Luning Prak, Eline T, Wherry, E John, Meyer, Nuala J, Betts, Michael R

“…Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we…”
Get more information

IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding by Bolton, Marcus J, Santos, Jefferson J S, Arevalo, Claudia P, Griesman, Trevor, Watson, Megan, Li, Shuk Hang, Bates, Paul, Ramage, Holly, Wilson, Patrick C, Hensley, Scott E

“…The constant domains of antibodies are important for effector functions, but less is known about how they can affect binding and neutralization of viruses…”
Get full text

Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021–22 Northern Hemisphere influenza season by Bolton, Marcus J., Ort, Jordan T., McBride, Ryan, Swanson, Nicholas J., Wilson, Jo, Awofolaju, Moses, Furey, Colleen, Greenplate, Allison R., Drapeau, Elizabeth M., Pekosz, Andrew, Paulson, James C., Hensley, Scott E.

“…Influenza viruses circulated at very low levels during the beginning of the COVID-19 pandemic, and population immunity against these viruses is low. An H3N2…”
Get full text

SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations by Anderson, Elizabeth M., Li, Shuk Hang, Awofolaju, Moses, Eilola, Theresa, Goodwin, Eileen, Bolton, Marcus J., Gouma, Sigrid, Manzoni, Tomaz B., Hicks, Philip, Goel, Rishi R., Painter, Mark M., Apostolidis, Sokratis A., Mathew, Divij, Dunbar, Debora, Fiore, Danielle, Brock, Amanda, Weaver, JoEllen, Millar, John S., DerOhannessian, Stephanie, Greenplate, Allison R., Frank, Ian, Rader, Daniel J., Wherry, E. John, Bates, Paul, Hensley, Scott E.

“…It is important to determine if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and SARS-CoV-2 mRNA vaccinations elicit different types…”
Get full text

SARS-CoV-2 seroprevalence among parturient women in Philadelphia by Flannery, Dustin D, Gouma, Sigrid, Dhudasia, Miren B, Mukhopadhyay, Sagori, Pfeifer, Madeline R, Woodford, Emily C, Gerber, Jeffrey S, Arevalo, Claudia P, Bolton, Marcus J, Weirick, Madison E, Goodwin, Eileen C, Anderson, Elizabeth M, Greenplate, Allison R, Kim, Justin, Han, Nicholas, Pattekar, Ajinkya, Dougherty, Jeanette, Kuthuru, Oliva, Mathew, Divij, Baxter, Amy E, Vella, Laura A, Weaver, JoEllen, Verma, Anurag, Leite, Rita, Morris, Jeffrey S, Rader, Daniel J, Elovitz, Michal A, Wherry, E John, Puopolo, Karen M, Hensley, Scott E

“…Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important for determining SARS-CoV-2 exposures within…”
Get more information

Convalescent plasma for pediatric patients with SARS‐CoV‐2‐associated acute respiratory distress syndrome by Diorio, Caroline, Anderson, Elizabeth M., McNerney, Kevin O., Goodwin, Eileen C., Chase, Julie C., Bolton, Marcus J., Arevalo, Claudia P., Weirick, Madison E., Gouma, Sigrid, Vella, Laura A., Henrickson, Sarah E., Chiotos, Kathleen, Fitzgerald, Julie C., Kilbaugh, Todd J., John, Audrey R. Odom, Blatz, Allison M., Lambert, Michele P., Sullivan, Kathleen E., Tartaglione, Margaret R., Zambrano, Danielle, Martin, Meghan, Lee, Jessica H., Young, Pampee, Friedman, David, Sesok‐Pizzini, Deborah A., Hensley, Scott E., Behrens, Edward M., Bassiri, Hamid, Teachey, David T.

“…There are no proven safe and effective therapies for children who develop life‐threatening complications of severe acute respiratory syndrome coronavirus 2…”
Get full text

Evolution of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence among employees of a US academic children’s hospital during coronavirus disease 2019 (COVID-19) pandemic by Fisher, Brian T., Sharova, Anna, Boge, Craig L. K., Gouma, Sigrid, Kamrin, Audrey, Blumenstock, Jesse, Shuster, Sydney, Gianchetti, Lauren, Collins, Danielle, Akaho, Elikplim, Weirick, Madison E., McAllister, Christopher M., Bolton, Marcus J., Arevalo, Claudia P., Goodwin, Eileen C., Anderson, Elizabeth M., Christensen, Shannon R., Balamuth, Fran, John, Audrey R. Odom, Li, Yun, Coffin, Susan, Gerber, Jeffrey S., Hensley, Scott E.

“…To describe the cumulative seroprevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) antibodies during the coronavirus disease 2019…”
Get full text

Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016 by Bolton, Marcus J., Abente, Eugenio J., Venkatesh, Divya, Stratton, Jered A., Zeller, Michael, Anderson, Tavis K., Lewis, Nicola S., Vincent, Amy L.

“…Background Six amino acid positions (145, 155, 156, 158, 159, and 189, referred to as the antigenic motif; H3 numbering) in the globular head region of…”
Get full text

Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19) by Anderson, Elizabeth M, Diorio, Caroline, Goodwin, Eileen C, McNerney, Kevin O, Weirick, Madison E, Gouma, Sigrid, Bolton, Marcus J, Arevalo, Claudia P, Chase, Julie, Hicks, Philip, Manzoni, Tomaz B, Baxter, Amy E, Andrea, Kurt P, Burudpakdee, Chakkapong, Lee, Jessica H, Vella, Laura A, Henrickson, Sarah E, Harris, Rebecca M, Wherry, E John, Bates, Paul, Bassiri, Hamid, Behrens, Edward M, Teachey, David T, Hensley, Scott E

“…Abstract Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric…”
Get full text

Antigenic and Biological Characterization of ORF2-6 Variants at Early Times Following PRRSV Infection by Evans, Alyssa B, Loyd, Hyelee, Dunkelberger, Jenelle R, van Tol, Sarah, Bolton, Marcus J, Dorman, Karin S, Dekkers, Jack C M, Carpenter, Susan

“…Genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) challenges efforts to develop effective and broadly acting vaccines. Although…”
Get full text

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications by Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John

“…Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional…”
Get full text

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 by Vella, Laura A, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Diorio, Caroline, Kuri-Cervantes, Leticia, Alanio, Cécile, Pampena, M Betina, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Anderson, Elizabeth M, Gouma, Sigrid, McNerney, Kevin O, Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H, Apostolidis, Sokratis A, Huang, Alexander C, Mathew, Divij, Kuthuru, Oliva, Goodwin, Eileen C, Weirick, Madison E, Bolton, Marcus J, Arevalo, Claudia P, Ramos, Andre, Jasen, C J, Conrey, Peyton E, Sayed, Samir, Giannini, Heather M, D'Andrea, Kurt, Meyer, Nuala J, Behrens, Edward M, Bassiri, Hamid, Hensley, Scott E, Henrickson, Sarah E, Teachey, David T, Betts, Michael R, Wherry, E John

“…Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children,…”
Get more information

Characterizing Viral Antigenic Drift and Using Immunoglobulin G3 to Increase Antibody Breadth by Bolton, Marcus J

“…Antigenic drift, the sequential accumulation of substitutions that enable escape from population immunity, is a constant problem for RNA viruses that circulate…”
Get full text

SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19 by Anderson, Elizabeth M, Diorio, Caroline, Goodwin, Eileen C, McNerney, Kevin O, Weirick, Madison E, Gouma, Sigrid, Bolton, Marcus J, Arevalo, Claudia P, Chase, Julie, Hicks, Philip, Manzoni, Tomaz B, Baxter, Amy E, Andrea, Kurt P, Burudpakdee, Chakkapong, Lee, Jessica H, Vella, Laura A, Henrickson, Sarah E, Harris, Rebecca M, Wherry, E John, Bates, Paul, Bassiri, Hamid, Behrens, Edward M, Teachey, David T, Hensley, Scott E

“…SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children…”
Get full text