Search Results - "Bolton, Judy L"

Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects by Bolton, Judy L, Dunlap, Tareisha

“…Quinones represent a class of toxicological intermediates, which can create a variety of hazardous effects in vivo including, acute cytotoxicity,…”
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Potential Mechanisms of Estrogen Quinone Carcinogenesis by Bolton, Judy L, Thatcher, Gregory R. J

“…There is a clear association between the excessive exposure to estrogens and the development of cancer in hormone-sensitive tissues (breast, endometrium). It…”
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Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women’s breast tissue by Hajirahimkhan, Atieh, Howell, Caitlin, Bartom, Elizabeth T., Dong, Huali, Lantvit, Daniel D., Xuei, Xiaoling, Chen, Shao-Nong, Pauli, Guido F., Bolton, Judy L., Clare, Susan E., Khan, Seema A., Dietz, Birgit M.

“…Breast cancer risk continues to increase post menopause. Anti-estrogen therapies are available to prevent postmenopausal breast cancer in high-risk women…”
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Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism by Dunlap, Tareisha L, Howell, Caitlin E, Mukand, Nita, Chen, Shao-Nong, Pauli, Guido F, Dietz, Birgit M, Bolton, Judy L

“…Many women consider botanical dietary supplements (BDSs) as safe alternatives to hormone therapy for menopausal symptoms. However, the effect of BDSs on breast…”
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Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops by van Breemen, Richard B, Yuan, Yang, Banuvar, Suzanne, Shulman, Lee P, Qiu, Xi, Alvarenga, René F. Ramos, Chen, Shao‐Nong, Dietz, Birgit M, Bolton, Judy L, Pauli, Guido F, Krause, Elizabeth, Viana, Marlos, Nikolic, Dejan

“…SCOPE: Women seeking alternatives to hormone‐replacement therapy for menopausal symptoms often try botanical dietary supplements containing extracts of hops…”
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Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms by Hajirahimkhan, Atieh, Simmler, Charlotte, Yuan, Yang, Anderson, Jeffrey R, Chen, Shao-Nong, Nikolić, Dejan, Dietz, Birgit M, Pauli, Guido F, van Breemen, Richard B, Bolton, Judy L

“…The increased cancer risk associated with hormone therapies has encouraged many women to seek non-hormonal alternatives including botanical supplements such as…”
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Dynamic Residual Complexity of the Isoliquiritigenin–Liquiritigenin Interconversion During Bioassay by Simmler, Charlotte, Hajirahimkhan, Atieh, Lankin, David C, Bolton, Judy L, Jones, Tristesse, Soejarto, Djaja D, Chen, Shao-Nong, Pauli, Guido F

“…Bioactive components in food plants can undergo dynamic processes that involve multiple chemical species. For example, 2′-hydroxychalcones can readily…”
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DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women’s Health by Dietz, Birgit M, Chen, Shao-Nong, Alvarenga, René F. Ramos, Dong, Huali, Nikolić, Dejan, Biendl, Martin, van Breemen, Richard B, Bolton, Judy L, Pauli, Guido F

“…Botanical dietary supplements contain multiple bioactive compounds that target numerous biological pathways. The lack of uniform standardization requirements…”
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Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. Inflata Extracts Modulate Estrogen Metabolism in ACI Rats by Wang, Shuai, Dunlap, Tareisha L, Huang, Lingyi, Liu, Yang, Simmler, Charlotte, Lantvit, Daniel D, Crosby, Jenna, Howell, Caitlin E, Dong, Huali, Chen, Shao-Nong, Pauli, Guido F, van Breemen, Richard B, Dietz, Birgit M, Bolton, Judy L

“…Women are increasingly using botanical dietary supplements (BDS) to reduce menopausal hot flashes. Although licorice ( sp.) is one of the frequently used…”
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Specificity of Human Aldo-Keto Reductases, NAD(P)H:Quinone Oxidoreductase, and Carbonyl Reductases to Redox-Cycle Polycyclic Aromatic Hydrocarbon Diones and 4-Hydroxyequilenin-o-quinone by Shultz, Carol A, Quinn, Amy M, Park, Jong-Heum, Harvey, Ronald G, Bolton, Judy L, Maser, Edmund, Penning, Trevor M

“…Polycyclic aromatic hydrocarbons (PAHs) are suspect human lung carcinogens and can be metabolically activated to remote quinones, for example,…”
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Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase by Dietz, Birgit M, Kang, Young-Hwa, Liu, Guowen, Eggler, Aimee L, Yao, Ping, Chadwick, Lucas R, Pauli, Guido F, Farnsworth, Norman R, Mesecar, Andrew D, van Breemen, Richard B, Bolton, Judy L

“…The female parts of hops (Humulus lupulus L.) show estrogenic effects as well as cancer chemopreventive potential. We analyzed the chemopreventive mechanism of…”
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Botanicals and Their Bioactive Phytochemicals for Women's Health by Dietz, Birgit M, Hajirahimkhan, Atieh, Dunlap, Tareisha L, Bolton, Judy L

“…Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function…”
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Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo by Dietz, Birgit M., Hagos, Ghenet K., Eskra, Jillian N., Wijewickrama, Gihani T., Anderson, Jeffrey R., Nikolic, Dejan, Guo, Jian, Wright, Brian, Chen, Shao-Nong, Pauli, Guido F., van Breemen, Richard B., Bolton, Judy L.

“…Scope Hops contain the phytoestrogen, 8‐prenylnaringenin, and the cytoprotective compound, xanthohumol (XH). XH induces the detoxification enzyme,…”
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Redox Cycling of Catechol Estrogens Generating Apurinic/Apyrimidinic Sites and 8-oxo-Deoxyguanosine via Reactive Oxygen Species Differentiates Equine and Human Estrogens by Wang, Zhican, Chandrasena, Esala R, Yuan, Yang, Peng, Kuan-wei, van Breemen, Richard B, Thatcher, Gregory R. J, Bolton, Judy L

“…Metabolic activation of estrogens to catechols and further oxidation to highly reactive o-quinones generates DNA damage including apurinic/apyrimidinic (AP)…”
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Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement by Krause, Elizabeth, Yuan, Yang, Hajirahimkhan, Atieh, Dong, Huali, Dietz, Birgit M., Nikolic, Dejan, Pauli, Guido F., Bolton, Judy L., van Breemen, Richard B.

“…ABSTRACT Concerned about the safety of conventional estrogen replacement therapy, women are using botanical dietary supplements as alternatives for the…”
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Angelica sinensis and Its Alkylphthalides Induce the Detoxification Enzyme NAD(P)H: Quinone Oxidoreductase 1 by Alkylating Keap1 by Dietz, Birgit M, Liu, Dongting, Hagos, Ghenet K, Yao, Ping, Schinkovitz, Andreas, Pro, Samuel M, Deng, Shixin, Farnsworth, Norman R, Pauli, Guido F, van Breemen, Richard B, Bolton, Judy L

“…The roots of Angelica sinensis (Oliv.) Diels (Dang Gui; Apiaceae) have a long history in traditional Chinese medicine as a remedy for women’s disorders and are…”
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Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms by Liu, Jianghua, Burdette, Joanna E, Xu, Haiyan, Gu, Chungang, van Breemen, Richard B, Bhat, Krishna P. L, Booth, Nancy, Constantinou, Andreas I, Pezzuto, John M, Fong, Harry H. S, Farnsworth, Norman R, Bolton, Judy L

“…Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red…”
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Serotonergic Activity-Guided Phytochemical Investigation of the Roots of Angelica sinensis by Deng, S, Chen, S.N, Yao, P, Nikolic, D, Van Breemen, R.B, Bolton, J.L, Fong, H.H.S, Farnsworth, N.R, Pauli, G.F

“…Serotonin receptor (5-HT(7)) binding assay-directed fractionation of a methanol extract of the dried roots of Angelica sinensis led to the isolation and…”
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Menopausal Hormone Therapy, Age, and Chronic Diseases: Perspectives on Statistical Trends by Bolton, Judy L

“…The release of the Women’s Health Initiative (WHI) study in 2002 was a shock to the medical community. Hormone therapy (HT) had generally been considered to be…”
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Black Cohosh Acts as a Mixed Competitive Ligand and Partial Agonist of the Serotonin Receptor by Burdette, Joanna E, Liu, Jianghua, Chen, Shao-nong, Fabricant, Daniel S, Piersen, Colleen E, Barker, Eric L, Pezzuto, John M, Mesecar, Andrew, van Breemen, Richard B, Farnsworth, Norman R, Bolton, Judy L

“…Extracts of the rhizome of black cohosh [Actaea racemosa L., formerly called Cimicifuga racemosa (L.) Nutt.] were evaluated for potential mechanisms of action…”
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