Search Results - "Boltje, Thomas J"

Sialic Acid Mimetics to Target the Sialic Acid–Siglec Axis by Büll, Christian, Heise, Torben, Adema, Gosse J., Boltje, Thomas J.

“…Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec)…”
Get full text

Sialic acid O-acetylation: From biosynthesis to roles in health and disease by Visser, Eline A., Moons, Sam J., Timmermans, Suzanne B.P.E., de Jong, Heleen, Boltje, Thomas J., Büll, Christian

“…Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of vertebrates as well as cells of certain types of invertebrates…”
Get full text

Probing the binding specificities of human Siglecs by cell-based glycan arrays by Büll, Christian, Nason, Rebecca, Sun, Lingbo, Van Coillie, Julie, Sørensen, Daniel Madriz, Moons, Sam J., Yang, Zhang, Arbitman, Steven, Fernandes, Steve M., Furukawa, Sanae, McBride, Ryan, Nycholat, Corwin M., Adema, Gosse J., Paulson, James C., Schnaar, Ronald L., Boltje, Thomas J., Clausen, Henrik, Narimatsu, Yoshiki

“…Siglecs are a family of sialic acid–binding receptors expressed by cells of the immune system and a few other cell types capable of modulating immune cell…”
Get full text

Direct Experimental Characterization of Glycosyl Cations by Infrared Ion Spectroscopy by Elferink, Hidde, Severijnen, Marion E, Martens, Jonathan, Mensink, Rens A, Berden, Giel, Oomens, Jos, Rutjes, Floris P. J. T, Rijs, Anouk M, Boltje, Thomas J

“…Glycosyl cations are crucial intermediates formed during enzymatic and chemical glycosylation. The intrinsic high reactivity and short lifetime of these…”
Get full text

Potent Metabolic Sialylation Inhibitors Based on C‑5-Modified Fluorinated Sialic Acids by Heise, Torben, Pijnenborg, Johan F. A, Büll, Christian, van Hilten, Niek, Kers-Rebel, Esther D, Balneger, Natasja, Elferink, Hidde, Adema, Gosse J, Boltje, Thomas J

“…Sialic acid sugars on mammalian cells regulate numerous biological processes, while aberrant expression of sialic acid is associated with diseases such as…”
Get full text

Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions by Hansen, Thomas, Elferink, Hidde, van Hengst, Jacob M. A., Houthuijs, Kas J., Remmerswaal, Wouter A., Kromm, Alexandra, Berden, Giel, van der Vorm, Stefan, Rijs, Anouk M., Overkleeft, Hermen S., Filippov, Dmitri V., Rutjes, Floris P. J. T., van der Marel, Gijsbert A., Martens, Jonathan, Oomens, Jos, Codée, Jeroen D. C., Boltje, Thomas J.

“…Controlling the chemical glycosylation reaction remains the major challenge in the synthesis of oligosaccharides. Though 1,2- trans glycosidic linkages can be…”
Get full text

Targeting aberrant sialylation in cancer cells using a fluorinated sialic acid analog impairs adhesion, migration, and in vivo tumor growth by Büll, Christian, Boltje, Thomas J, Wassink, Melissa, de Graaf, Annemarie M A, van Delft, Floris L, den Brok, Martijn H, Adema, Gosse J

“…Cancer cells decorate their surface with a dense layer of sialylated glycans by upregulating the expression of sialyltransferases and other glycogenes…”
Get full text

Fluorinated rhamnosides inhibit cellular fucosylation by Pijnenborg, Johan F. A., Rossing, Emiel, Merx, Jona, Noga, Marek J., Titulaer, Willem H. C., Eerden, Nienke, Veizaj, Raisa, White, Paul B., Lefeber, Dirk J., Boltje, Thomas J.

“…The sugar fucose is expressed on mammalian cell membranes as part of glycoconjugates and mediates essential physiological processes. The aberrant expression of…”
Get full text

Polysialic Acid Sustains the Hypoxia-Induced Migration and Undifferentiated State of Human Glioblastoma Cells by Rosa, Paolo, Scibetta, Sofia, Pepe, Giuseppe, Mangino, Giorgio, Capocci, Luca, Moons, Sam J., Boltje, Thomas J., Fazi, Francesco, Petrozza, Vincenzo, Di Pardo, Alba, Maglione, Vittorio, Calogero, Antonella

“…Gliomas are the most common primary malignant brain tumors. Glioblastoma, IDH-wildtype (GBM, CNS WHO grade 4) is the most aggressive form of glioma and is…”
Get full text

Characterization of elusive rhamnosyl dioxanium ions and their application in complex oligosaccharide synthesis by Moons, Peter H., ter Braak, Floor, de Kleijne, Frank F. J., Bijleveld, Bart, Corver, Sybren J. R., Houthuijs, Kas J., Almizori, Hero R., Berden, Giel, Martens, Jonathan, Oomens, Jos, White, Paul B., Boltje, Thomas J.

“…Attaining complete anomeric control is still one of the biggest challenges in carbohydrate chemistry. Glycosyl cations such as oxocarbenium and dioxanium ions…”
Get full text

Mammalian cell-based production of glycans, glycopeptides and glycomodules by Jaroentomeechai, Thapakorn, Karlsson, Richard, Goerdeler, Felix, Teoh, Fallen Kai Yik, Grønset, Magnus Nørregaard, de Wit, Dylan, Chen, Yen-Hsi, Furukawa, Sanae, Psomiadou, Venetia, Hurtado-Guerrero, Ramon, Vidal-Calvo, Elena Ethel, Salanti, Ali, Boltje, Thomas J., van den Bos, Leendert J., Wunder, Christian, Johannes, Ludger, Schjoldager, Katrine T., Joshi, Hiren J., Miller, Rebecca L., Clausen, Henrik, Vakhrushev, Sergey Y., Narimatsu, Yoshiki

“…Access to defined glycans and glycoconjugates is pivotal for discovery, dissection, and harnessing of a range of biological functions orchestrated by cellular…”
Get full text

Identification of global inhibitors of cellular glycosylation by Sørensen, Daniel Madriz, Büll, Christian, Madsen, Thomas D., Lira-Navarrete, Erandi, Clausen, Thomas Mandel, Clark, Alex E., Garretson, Aaron F., Karlsson, Richard, Pijnenborg, Johan F. A., Yin, Xin, Miller, Rebecca L., Chanda, Sumit K., Boltje, Thomas J., Schjoldager, Katrine T., Vakhrushev, Sergey Y., Halim, Adnan, Esko, Jeffrey D., Carlin, Aaron F., Hurtado-Guerrero, Ramon, Weigert, Roberto, Clausen, Henrik, Narimatsu, Yoshiki

“…Small molecule inhibitors of glycosylation enzymes are valuable tools for dissecting glycan functions and potential drug candidates. Screening for inhibitors…”
Get full text

Investigation of in vitro histone H3 glycosylation using H3 tail peptides by Merx, Jona, Hintzen, Jordi C. J., Proietti, Giordano, Elferink, Hidde, Wang, Yali, Porzberg, Miriam R. B., Sondag, Daan, Bilgin, Nurgül, Park, Jin, Mecinović, Jasmin, Boltje, Thomas J.

“…Posttranslational modifications (PTMs) on histone tails regulate eukaryotic gene expression by impacting the chromatin structure and by modulating interactions…”
Get full text

Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2 by van den Bijgaart, Renske J.E., Kroesen, Michiel, Wassink, Melissa, Brok, Ingrid C., Kers-Rebel, Esther D., Boon, Louis, Heise, Torben, van Scherpenzeel, Monique, Lefeber, Dirk J., Boltje, Thomas J., den Brok, Martijn H., Hoogerbrugge, Peter M., Büll, Christian, Adema, Gosse J.

“…Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is only sparsely expressed on healthy tissue. GD2…”
Get full text

Uptake of Sialic Acid by Nontypeable Haemophilus influenzae Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation by Oerlemans, Marjolein M P, Moons, Sam J, Heming, Jurriaan J A, Boltje, Thomas J, de Jonge, Marien I, Langereis, Jeroen D

“…Although nontypeable (NTHi) is a human-specific nasopharyngeal commensal bacterium, it also causes upper respiratory tract infections in children and lower…”
Get full text

Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry by Büll, Christian, Heise, Torben, van Hilten, Niek, Pijnenborg, Johan F. A., Bloemendal, Victor R. L. J., Gerrits, Lotte, Kers‐Rebel, Esther D., Ritschel, Tina, den Brok, Martijn H., Adema, Gosse J., Boltje, Thomas J.

“…Sialic acid sugars that terminate cell‐surface glycans form the ligands for the sialic acid binding immunoglobulin‐like lectin (Siglec) family, which are…”
Get full text

Chemical Synthesis and Immunological Evaluation of the Inner Core Oligosaccharide of Francisella tularensis by Boltje, Thomas J, Zhong, Wei, Park, Jin, Wolfert, Margreet A, Chen, Wangxue, Boons, Geert-Jan

“…Francisella tularensis, which is a Gram negative bacterium that causes tularemia, has been classified by the Center for Disease Control and Prevention (CDC) as…”
Get full text

Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases by Al Temimi, Abbas H. K., Merx, Jona, van Noortwijk, Christian J., Proietti, Giordano, Buijs, Romano, White, Paul B., Rutjes, Floris P. J. T., Boltje, Thomas J., Mecinović, Jasmin

“…Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery…”
Get full text

Versatile Set of Orthogonal Protecting Groups for the Preparation of Highly Branched Oligosaccharides by Boltje, Thomas J, Li, Chunxia, Boons, Geert-Jan

“…A new set of orthogonal protecting groups has been developed based on the use of a diethylisopropylsilyl (DEIPS), methylnaphthyl (Nap), allyl ether, and…”
Get full text

Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry by Gansevoort, Merel, Merx, Jona, Versteeg, Elly M. M, Vuckovic, Isidora, Boltje, Thomas J, van Kuppevelt, Toin H, Daamen, Willeke F

“…The process of wound healing is a tightly controlled cascade of events, where severe skin wounds are resolved via scar tissue. This fibrotic response may be…”
Get full text