Search Results - "Bolte, Jean"

Facilitating translational team science: The project leader model by Sutton, Lynn, Berdan, Lisa G., Bolte, Jean, Califf, Robert M., Ginsburg, Geoffrey S., Li, Jennifer S., McCall, Jonathan, Moen, Rebbecca, Myers, Barry S., Rodriquez, Vonda, Veldman, Tim, Boulware, L. Ebony

“…Abstract Project management expertise is employed across many professional sectors, including clinical research organizations, to ensure that efforts…”
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Stereoselective Chemoenzymatic Synthesis of the Four Stereoisomers of l-2-(2-Carboxycyclobutyl)glycine and Pharmacological Characterization at Human Excitatory Amino Acid Transporter Subtypes 1, 2, and 3 by Faure, Sophie, Jensen, Anders A, Maurat, Vincent, Gu, Xin, Sagot, Emmanuelle, Aitken, David J, Bolte, Jean, Gefflaut, Thierry, Bunch, Lennart

“…The four stereoisomers of l-2-(2-carboxycyclobutyl)glycine, l-CBG-I, l-CBG-II, l-CBG-III, and l-CBG-IV, were synthesized in good yield and high enantiomeric…”
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Chemo-enzymatic synthesis of the four stereoisomers of 4-hydroxy-4-methylglutamic acid by Helaine, Virgil, Bolte, Jean

“…A chemo-enzymatic synthesis of the four stereoisomers of 4-hydroxy-4-methylglutamic acid is described. As with other glutamate analogues these compounds can…”
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Deoxysugars via Microbial Reduction of 5-Acyl-isoxazolines: Application to the Synthesis of 3-Deoxy-d-fructose and Derivatives by Gefflaut, Thierry, Martin, Christel, Delor, Suzy, Besse, Pascale, Veschambre, Henri, Bolte, Jean

“…5-Acylisoxazolines 3a−d were obtained by 1,3-dipolar cycloaddition from acetoxymethyl vinyl ketone and nitro precursors. Compounds 3a−d were biotransformed by…”
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Toward Designing Information Display to Support Critical Care. A Qualitative Contextual Evaluation and Visioning Effort by Wright, Melanie C, Dunbar, Sherry, Macpherson, Brekk C, Moretti, Eugene W, Del Fiol, Guillherme, Bolte, Jean, Taekman, Jeffrey M, Segall, Noa

“…Electronic health information overload makes it difficult for providers to quickly find and interpret information to support care decisions. The purpose of…”
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New Assays for Transketolase by Hecquet, Laurence, Bolte, Jean, Demuynck, Colette

“…Given the importance of transketolase, TK (EC 2.2.1.1) for both pharmacological studies and synthetic purposes, the need for a simple and inexpensive assay is…”
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Straightforward chemo-enzymatic synthesis of new aminocyclitols, analogues of valiolamine and their evaluation as glycosidase inhibitors by El Blidi, Lahssen, Ahbala, Mustapha, Bolte, Jean, Lemaire, Marielle

“…An efficient fructose-1,6-bisphosphate aldolase mediated synthesis of new aminocyclitol analogues of valiolamine is described. The one-pot process where four…”
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Chemo-Enzymatic Synthesis of a Series of 2,4-Syn-Functionalized (S)-Glutamate Analogues: New Insight into the Structure−Activity Relation of Ionotropic Glutamate Receptor Subtypes 5, 6, and 7 by Sagot, Emanuelle, Pickering, Darryl S, Pu, Xiaosui, Umberti, Michelle, Stensbøl, Tine B, Nielsen, Birgitte, Chapelet, Marion, Bolte, Jean, Gefflaut, Thierry, Bunch, Lennart

“…(S)-Glutamic acid (Glu) is the major excitatory neurotransmitter in the central nervous system (CNS) activating the plethora of ionotropic Glu receptors…”
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Synthesis of New Nitrogen Analogues of Salacinol and Deoxynojirimycin and Their Evaluation as Glycosidase Inhibitors by Gallienne, Estelle, Gefflaut, Thierry, Bolte, Jean, Lemaire, Marielle

“…The synthesis of two enantiomerically pure iminosugars, analogues of 1-l-deoxynojirimycin (l-DNJ) and 1-d-deoxymannojirimycin (DMJ), was achieved using cyclic…”
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Cycle Time Metrics for Multisite Clinical Trials in the United States by Abbott, Diana, Califf, Robert, Morrison, Briggs W., Pierre, Christine, Bolte, Jean, Chakraborty, Swati

“…Conducting randomized controlled trials entails a prolonged, costly study start-up (SSU) process that may create significant delays. Optimizing the operational…”
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Monitoring the quality of clinical inquiry projects by Bolte, Jean, Granger, Bradi B

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Fructose-1,6-Bisphosphate Aldolase-Mediated Synthesis of Aminocyclitols (Analogues of Valiolamine) and their Evaluation as Glycosidase Inhibitors by El Blidi, Lahssen, Assaf, Zeinab, Camps Bres, Flora, Veschambre, Henri, Théry, Vincent, Bolte, Jean, Lemaire, Marielle

“…A highly stereoselective method for the preparation of nitro‐ and aminocyclitols, using fructose‐1,6‐bisphosphate aldolase, which catalyzes the aldol reaction…”
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Short synthesis of new salacinol analogues and their evaluation as glycosidase inhibitors by Gallienne, Estelle, Benazza, Mohammed, Demailly, Gilles, Bolte, Jean, Lemaire, Marielle

“…Versatile synthesis of some analogues of the naturally-occurring α-glucosidase inhibitor salacinol ( 1 ), involving thioanhydro alditol moieties with erythro,…”
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First lipase catalysed resolution of epoxy enol esters by Gravil, Sébastien, Veschambre, Henri, Chênevert, Robert, Bolte, Jean

“…We report the first enzyme-catalysed kinetic resolution of epoxy enol esters. The lipase-promoted hydrolysis of these compounds provided α-hydroxyketones or…”
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Biotransformation of nitriles to amides using soluble and immobilized nitrile hydratase from Rhodococcus erythropolis A4 by Kubáč, David, Kaplan, Ondřej, Elišáková, Veronika, Pátek, Miroslav, Vejvoda, Vojtěch, Slámová, Kristýna, Tóthová, Andrea, Lemaire, Marielle, Gallienne, Estelle, Lutz-Wahl, Sabine, Fischer, Lutz, Kuzma, Marek, Pelantová, Helena, van Pelt, Sander, Bolte, Jean, Křen, Vladimír, Martínková, Ludmila

“…A semi-purified nitrile hydratase from Rhodococcus erythropolis A4 was applied to biotransformations of 3-oxonitriles 1a– 4a, 3-hydroxy-2-methylenenitriles 5a–…”
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A straightforward synthesis of an aminocyclitol based on an enzymatic aldol reaction and a highly stereoselective intramolecular Henry reaction by El Blidi, Lahssen, Crestia, Dominique, Gallienne, Estelle, Demuynck, Colette, Bolte, Jean, Lemaire, Marielle

“…[Display omitted] The reactions of 4-nitroaldehydes 9 and 10 with dihydroxyacetonephosphate (DHAP) catalyzed by fructose-1,6-diphosphate aldolase from rabbit…”
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Chemo-Enzymatic Synthesis of (2S,4R)-2-Amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic Acid: A Novel Selective Inhibitor of Human Excitatory Amino Acid Transporter Subtype 2 by Sagot, Emanuelle, Jensen, Anders A, Pickering, Darryl S, Pu, Xiaosui, Umberti, Michelle, Stensbøl, Tine B, Nielsen, Birgitte, Assaf, Zeinab, Aboab, Bétina, Bolte, Jean, Gefflaut, Thierry, Bunch, Lennart

“…In the mammalian central nervous system (CNS), the action of sodium dependent excitatory amino acid transporters (EAATs) is responsible for termination of…”
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Synthesis of the constrained glutamate analogues (2 S,1′ R,2′ R)- and (2 S,1′ S,2′ S)-2-(2′-carboxycyclobutyl)glycines L-CBG-II and L-CBG-I by enzymatic transamination by Gu, Xin, Xian, Mo, Roy-Faure, Sophie, Bolte, Jean, Aitken, David J., Gefflaut, Thierry

“…Optically pure trans-cyclobutane analogues of glutamic acid are prepared by highly selective enzymatic transamination of a single racemic trans-cyclobutane…”
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Improved Straightforward Chemical Synthesis of Dihydroxyacetone Phosphate through Enzymatic Desymmetrization of 2,2-Dimethoxypropane-1,3-diol by Charmantray, Franck, El Blidi, Lahssen, Gefflaut, Thierry, Hecquet, Laurence, Bolte, Jean, Lemaire, Marielle

“…Dihydroxyacetone phosphate (DHAP) was synthesized in high purity and yield in four steps starting from dihydroxyacetone dimer (DHA) (47% overall yield). DHA…”
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Chemoenzymatic Synthesis of a Series of 4-Substituted Glutamate Analogues and Pharmacological Characterization at Human Glutamate Transporters Subtypes 1−3 by Alaux, Sebastien, Kusk, Mie, Sagot, Emanuelle, Bolte, Jean, Jensen, Anders A, Bräuner-Osborne, Hans, Gefflaut, Thierry, Bunch, Lennart

“…A series of nine l-2,4-syn-4-alkylglutamic acid analogues (1a − i) were synthesized in high yield and high enantiomeric excess (>99% ee) from their…”
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