Search Results - "Bolte, Craig"
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FOXF1 Transcription Factor Is Required for Formation of Embryonic Vasculature by Regulating VEGF Signaling in Endothelial Cells
Published in Circulation research (26-09-2014)“…RATIONALE:Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary…”
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FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme
Published in Developmental biology (01-11-2018)“…Organogenesis is regulated by mesenchymal-epithelial signaling events that induce expression of cell-type specific transcription factors critical for cellular…”
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Foxm1 regulates resolution of hyperoxic lung injury in newborns
Published in American journal of respiratory cell and molecular biology (01-05-2015)“…Current treatments for inflammation associated with bronchopulmonary dysplasia (BPD) fail to show clinical efficacy. Foxm1, a transcription factor of the…”
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Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development
Published in PloS one (14-07-2011)“…Forkhead Box M1 (Foxm1) is a transcription factor essential for organ morphogenesis and development of various cancers. Although complete deletion of Foxm1 in…”
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Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling
Published in PloS one (08-11-2012)“…Heart disease remains a leading cause of morbidity and mortality in the industrialized world. Hypertrophic cardiomyopathy is the most common genetic…”
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The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis
Published in Biology open (11-02-2019)“…Hepatic fibrosis is the common end stage to a variety of chronic liver injuries and is characterized by an excessive deposition of extracellular matrix (ECM),…”
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Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature
Published in Advances in anatomy, embryology and cell biology (01-01-2018)“…Lung morphogenesis is a highly orchestrated process beginning with the appearance of lung buds on approximately embryonic day 9.5 in the mouse. Endodermally…”
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Cardiac-specific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of low-flow ischemia
Published in Circulation (New York, N.Y.) (23-12-2003)“…Preconditioning the heart before an ischemic insult has been shown to protect against contractile dysfunction, arrhythmias, and infarction. Pharmacological…”
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Remote preconditioning-endocrine factors in organ protection against ischemic injury
Published in Endocrine, metabolic & immune disorders drug targets (01-09-2007)“…Cardiovascular disease is the leading cause of death in the United States and developing world. Experimental and clinical studies have demonstrated that a…”
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Molecular, cellular, and bioengineering approaches to stimulate lung regeneration after injury
Published in Seminars in cell & developmental biology (01-04-2020)“…The lung is susceptible to damage from a variety of sources throughout development and in adulthood. As a result, the lung has great capacities for repair and…”
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Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT + Endothelial Progenitor Cells
Published in American journal of respiratory and critical care medicine (01-11-2019)“…Disruption of alveologenesis is associated with severe pediatric lung disorders, including bronchopulmonary dysplasia (BPD). Although c-KIT endothelial cell…”
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FOXF1 maintains endothelial barrier function and prevents edema after lung injury
Published in Science signaling (19-04-2016)“…Multiple signaling pathways, structural proteins, and transcription factors are involved in the regulation of endothelial barrier function. The forkhead…”
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FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy
Published in Scientific reports (06-09-2017)“…FOXF1, a member of the forkhead box family of transcription factors, has been previously shown to be critical for lung development, homeostasis, and injury…”
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The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia
Published in American journal of respiratory and critical care medicine (15-10-2019)“…Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal congenital disorder causing respiratory failure and pulmonary…”
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Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia
Published in American journal of respiratory and critical care medicine (01-07-2020)“…: Advances in neonatal critical care have greatly improved the survival of preterm infants, but the long-term complications of prematurity, including…”
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Forkhead Box F2 Regulation of Platelet-derived Growth Factor and Myocardin/Serum Response Factor Signaling Is Essential for Intestinal Development
Published in The Journal of biological chemistry (20-03-2015)“…Alterations in the forkhead box F2 gene expression have been reported in numerous pathologies, and Foxf2−/− mice are perinatal lethal with multiple…”
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Abstract C14: Foxf1 transcription factor reprograms pulmonary endothelial cells to promote metastasis
Published in Cancer research (Chicago, Ill.) (01-08-2016)“…The ability to form a metastatic niche is a unique feature of tumor cells. The niche provides signals for tumor cells extravasation, survival, dormancy or…”
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Kappa and delta opioid receptor signaling is augmented in the failing heart
Published in Journal of molecular and cellular cardiology (01-10-2009)“…Abstract The opioidergic system, an endogenous stress pathway, modulates cardiac function. Furthermore, opioid peptide and receptor expression is altered in a…”
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Opioid receptor activation alters beta‐adrenergic receptor function in heart failure
Published in The FASEB journal (01-04-2012)“…Abstract only Our lab previously demonstrated that opioid receptor (OR) stimulation significantly enhanced the decreased cardiac function in animal models…”
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Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation
Published in American journal of physiology. Heart and circulatory physiology (01-04-2009)“…Opioids/opiates are commonly administered to alleviate pain, unload the heart, or decrease breathlessness in patients with advanced heart failure. As such, it…”
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