Search Results - "Bolognese, J."

Adverse Upper Gastrointestinal Effects of Rofecoxib Compared With NSAIDs by Langman, Michael J, Jensen, Dennis M, Watson, Douglas J, Harper, Sean E, Zhao, Peng-Liang, Quan, Hui, Bolognese, James A, Simon, Thomas J

“…CONTEXT Nonsteroidal anti-inflammatory drug (NSAID)–induced gastrointestinal (GI) toxic effects, such as upper GI tract perforations, symptomatic…”
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Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities osteoarthritis index questionnaire and global assessments in patients with osteoarthritis by Ehrich, E W, Davies, G M, Watson, D J, Bolognese, J A, Seidenberg, B C, Bellamy, N

“…To determine the minimal perceptible clinical improvement (MPCI) in patients with osteoarthritis (OA) with the Western Ontario and McMaster Universities…”
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A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit by Podolin, Patricia L, Bolognese, Brian J, Foley, James J, Schmidt, Dulcie B, Buckley, Peter T, Widdowson, Katherine L, Jin, Qi, White, John R, Lee, Judithann M, Goodman, Richard B, Hagen, Tonja R, Kajikawa, Osamu, Marshall, Lisa A, Hay, Douglas W. P, Sarau, Henry M

“…Much evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheumatoid arthritis. The effects of IL-8 and its related ligands…”
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Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement by Harrison, Oliver J, Foley, Joseph, Bolognese, Brian J, Long, Edward, Podolin, Patricia L, Walsh, Patrick T

“…Abstract Recently, patients with tobacco smoke induced emphysema have been shown to exhibit classical signs of T cell mediated autoimmunity characterized by…”
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A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2–specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis by Laine, Loren, Harper, Sean, Simon, Thomas, Bath, Richard, Johanson, John, Schwartz, Howard, Stern, Steven, Quan, Hui, Bolognese, James

“…Background & Aims: Prostaglandin production in the normal gastrointestinal tract, believed to be critical for mucosal integrity, is mediated by cyclooxygenase…”
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Prolonged joint residency of triamcinolone acetonide after an intra-articular injection of FX006, a sustained release formulation for the treatment of osteoarthritis by Bodick, N, Lufkin, J, Willwerth, C, Hauben, J, Kumar, A, Boen, P, Bolognese, J, Schoonmaker, C, Clayman, M

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Specific inhibition of cyclooxygenase‐2 with MK‐0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen by Lanza, F. L., Rack, M. F., Simon, T. J., Quan, H., Bolognese, J. A., Hoover, M. E., Wilson, F. R., Harper, S. E.

“…Background : Compared with currently available NSAIDs (which inhibit COX‐1 and COX‐2 isoforms of cyclooxy‐ genase), MK‐0966 (a specific COX‐2 inhibitor) is…”
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SP1-101 A model of international multi-site collaboration for chronic disease research in developing countries by Qian, H Z, Dianis, N, Bolognese, J

“…The impact of chronic diseases continues escalating among populations in developing countries. In an effort to combat chronic cardiovascular and lung diseases…”
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PRM110 Planning and Executing Qualitative Research With Adolescents in an Orphan Disease by Cole, J.C, Urwongse, J, Bolognese, J, Cheng, R

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WS13.1 QR-010, an investigational RNA therapeutic, improves CFTR activity in cystic fibrosis subjects homozygous for the F508del mutation by Rowe, S, Sermet-Gaudelus, I, Clancy, J.P, Nichols, D, Nick, J, De Boeck, K, Solomon, G, Elborn, J.S, Mall, M.A, Bolognese, J, Bouisset, F, den Hollander, W, Lamontagne, N, Tomkinson, N, Henig, N

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Safety and efficacy of FX006 in patients with osteoarthritis of the knee by Bodick, N, Lufkin, J, Willwerth, C, Kumar, A, Bolognese, J, Schoonmaker, C, Hunter, D, Clayman, M.D

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PRM40 A Look At Previous and Current Methods Used to Collect Patient-Reported Outcomes Information by Bergstrom, F, Bolognese, J, Tran, D

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Cervical ultrasonography compared with manual examination as a predictor of preterm delivery by Berghella, Vincenzo, Tolosa, Jorge E., Kuhlman, Kathleen, Weiner, Stuart, Bolognese, Ronald J., Wapner, Ronald J.

“…OBJECTIVE: Our purpose was to compare the accuracy of ultrasonographic and manual cervical examinations for the prediction of preterm delivery. STUDY DESIGN:…”
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TIPIFARNIB IN RELAPSED OR REFRACTORY ANGIOIMMUNOBLASTIC T‐CELL LYMPHOMA (AITL) AND CXCL12+ PERIPHERAL T‐CELL LYMPHOMA (PTCL): PRELIMINARY RESULTS FROM A PHASE 2 STUDY by Witzig, T., Sokol, L., Kim, W., Foss, F., Jacobsen, E., Cruz Vincente, F., Caballero, D., Advani, R., Roncero Vidal, J.M., Marin‐Niebla, A., Rodriguez Izquierdo, A., Ona Navarrete, R., Terol, M.J., Domingo‐Domenech, E., Rodriguez, M., Piris, M.A., Bolognese, J., Janes, M.R., Burrows, F., Kessler, L., Mishra, V., Curry, R., Kurman, M., Scholz, C., Gualberto, A.

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Klotho and smoking – An interplay influencing the skeletal muscle function deficits that occur in COPD by Patel, M.S, Donaldson, A.V, Lewis, A, Natanek, S.A, Lee, J.Y, Andersson, Y.M, Haji, G, Jackson, S.G, Bolognese, B.J, Foley, J.P, Podolin, P.L, Bruijnzeel, P.L.B, Hart, N, Hopkinson, N.S, Man, W.D.-C, Kemp, P.R, Polkey, M.I

“…Abstract Background Klotho is an ‘anti-ageing’ hormone and transmembrane protein; Klotho deficient mice develop a similar ageing phenotype to smokers including…”
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COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin by Sigthorsson, G, Crane, R, Simon, T, Hoover, M, Quan, H, Bolognese, J, Bjarnason, I

“…BACKGROUND Acute and chronic use of non-steroidal anti-inflammatory drugs can increase intestinal permeability. Rofecoxib, which selectively inhibits…”
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P1-497 Support and administration of the multi-site global health initiative program of combating non-communicable chronic cardiovascular and pulmonary diseases in developing Countries by Qian, H Z, Dianis, R N N, Wolbach, T, Bolognese, J

“…The National Heart, Lung and Blood Institute (NHLBI) teamed with United Health Group's Chronic Disease Initiative (CDI) to reduce the burden of noncommunicable…”
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Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery by Davies, Thomas G, Wixted, William E, Coyle, Joseph E, Griffiths-Jones, Charlotte, Hearn, Keisha, McMenamin, Rachel, Norton, David, Rich, Sharna J, Richardson, Caroline, Saxty, Gordon, Willems, Henriëtte M. G, Woolford, Alison J.-A, Cottom, Joshua E, Kou, Jen-Pyng, Yonchuk, John G, Feldser, Heidi G, Sanchez, Yolanda, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Podolin, Patricia L, Yan, Hongxing, Callahan, James F, Heightman, Tom D, Kerns, Jeffrey K

“…KEAP1 is the key regulator of the NRF2-mediated cytoprotective response, and increasingly recognized as a target for diseases involving oxidative stress…”
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Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials by Hawkey, C. J., Laine, L., Harper, S. E., Quan, H. U. I., Bolognese, J. A., Mortensen, E.

“…Background: Highly selective inhibitors of the inducible cyclooxygenase‐2 enzyme (coxibs) have been associated with less gastrotoxicity than nonselective…”
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A walking model to assess the onset of analgesia in osteoarthritis knee pain by Peeva, E, Beals, C.R, Bolognese, J.A, Kivitz, A.J, Taber, L, Harman, A, Smugar, S.S, Moskowitz, R.W

“…Summary Objective To assess a walking model utilizing a set of standardized treadmill walks to measure acute analgesic response in osteoarthritis (OA) of the…”
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