Search Results - "Bologa, Cristian"

DrugCentral: online drug compendium by Ursu, Oleg, Holmes, Jayme, Knockel, Jeffrey, Bologa, Cristian G, Yang, Jeremy J, Mathias, Stephen L, Nelson, Stuart J, Oprea, Tudor I

“…DrugCentral (http://drugcentral.org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions…”
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DrugCentral 2023 extends human clinical data and integrates veterinary drugs by Avram, Sorin, Wilson, Thomas B, Curpan, Ramona, Halip, Liliana, Borota, Ana, Bora, Alina, Bologa, Cristian G, Holmes, Jayme, Knockel, Jeffrey, Yang, Jeremy J, Oprea, Tudor I

“…DrugCentral monitors new drug approvals and standardizes drug information. The current update contains 285 drugs (131 for human use). New additions include:…”
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How many rare diseases are there? by Haendel, Melissa, Vasilevsky, Nicole, Unni, Deepak, Bologa, Cristian, Harris, Nomi, Rehm, Heidi, Hamosh, Ada, Baynam, Gareth, Groza, Tudor, McMurry, Julie, Dawkins, Hugh, Rath, Ana, Thaxton, Courtney, Bocci, Giovanni, Joachimiak, Marcin P., Köhler, Sebastian, Robinson, Peter N., Mungall, Chris, Oprea, Tudor I.

“…A lack of robust knowledge of the number of rare diseases and the number of people affected by them limits the development of approaches to ameliorate the…”
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DrugCentral 2018: an update by Ursu, Oleg, Holmes, Jayme, Bologa, Cristian G, Yang, Jeremy J, Mathias, Stephen L, Stathias, Vasileios, Nguyen, Dac-Trung, Schürer, Stephan, Oprea, Tudor

“…Abstract DrugCentral is a drug information resource (http://drugcentral.org) open to the public since 2016 and previously described in the 2017 Nucleic Acids…”
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DrugCentral 2021 supports drug discovery and repositioning by Avram, Sorin, Bologa, Cristian G, Holmes, Jayme, Bocci, Giovanni, Wilson, Thomas B, Nguyen, Dac-Trung, Curpan, Ramona, Halip, Liliana, Bora, Alina, Yang, Jeremy J, Knockel, Jeffrey, Sirimulla, Suman, Ursu, Oleg, Oprea, Tudor I

“…Abstract DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described…”
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Pharos 2023: an integrated resource for the understudied human proteome by Kelleher, Keith J, Sheils, Timothy K, Mathias, Stephen L, Yang, Jeremy J, Metzger, Vincent T, Siramshetty, Vishal B, Nguyen, Dac-Trung, Jensen, Lars Juhl, Vidović, Dušica, Schürer, Stephan C, Holmes, Jayme, Sharma, Karlie R, Pillai, Ajay, Bologa, Cristian G, Edwards, Jeremy S, Mathé, Ewy A, Oprea, Tudor I

“…The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of…”
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XCOVNet: Chest X-ray Image Classification for COVID-19 Early Detection Using Convolutional Neural Networks by Madaan, Vishu, Roy, Aditya, Gupta, Charu, Agrawal, Prateek, Sharma, Anand, Bologa, Cristian, Prodan, Radu

“…COVID-19 (also known as SARS-COV-2) pandemic has spread in the entire world. It is a contagious disease that easily spreads from one person in direct contact…”
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Unexplored therapeutic opportunities in the human genome by Oprea, Tudor I., Bologa, Cristian G., Brunak, Søren, Campbell, Allen, Gan, Gregory N., Gaulton, Anna, Gomez, Shawn M., Guha, Rajarshi, Hersey, Anne, Holmes, Jayme, Jadhav, Ajit, Jensen, Lars Juhl, Johnson, Gary L., Karlson, Anneli, Leach, Andrew R., Ma'ayan, Avi, Malovannaya, Anna, Mani, Subramani, Mathias, Stephen L., McManus, Michael T., Meehan, Terrence F., von Mering, Christian, Muthas, Daniel, Nguyen, Dac-Trung, Overington, John P., Papadatos, George, Qin, Jun, Reich, Christian, Roth, Bryan L., Schürer, Stephan C., Simeonov, Anton, Sklar, Larry A., Southall, Noel, Tomita, Susumu, Tudose, Ilinca, Ursu, Oleg, Vidović, Dušica, Waller, Anna, Westergaard, David, Yang, Jeremy J., Zahoránszky-Köhalmi, Gergely

“…In 2014, the Illuminating the Druggable Genome programme was launched to promote the exploration of currently understudied but potentially druggable proteins…”
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TCRD and Pharos 2021: mining the human proteome for disease biology by Sheils, Timothy K, Mathias, Stephen L, Kelleher, Keith J, Siramshetty, Vishal B, Nguyen, Dac-Trung, Bologa, Cristian G, Jensen, Lars Juhl, Vidović, Dušica, Koleti, Amar, Schürer, Stephan C, Waller, Anna, Yang, Jeremy J, Holmes, Jayme, Bocci, Giovanni, Southall, Noel, Dharkar, Poorva, Mathé, Ewy, Simeonov, Anton, Oprea, Tudor I

“…Abstract In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our…”
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Pharos: Collating protein information to shed light on the druggable genome by Nguyen, Dac-Trung, Mathias, Stephen, Bologa, Cristian, Brunak, Soren, Fernandez, Nicolas, Gaulton, Anna, Hersey, Anne, Holmes, Jayme, Jensen, Lars Juhl, Karlsson, Anneli, Liu, Guixia, Ma'ayan, Avi, Mandava, Geetha, Mani, Subramani, Mehta, Saurabh, Overington, John, Patel, Juhee, Rouillard, Andrew D, Schürer, Stephan, Sheils, Timothy, Simeonov, Anton, Sklar, Larry A, Southall, Noel, Ursu, Oleg, Vidovic, Dusica, Waller, Anna, Yang, Jeremy, Jadhav, Ajit, Oprea, Tudor I, Guha, Rajarshi

“…The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus…”
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Outcomes of Hospital-Acquired Hypernatremia by Arzhan, Soraya, Roumelioti, Maria-Eleni, Litvinovich, Igor, Bologa, Cristian G., Unruh, Mark L.

“…Background Hospital-acquired hypernatremia is highly prevalent, overlooked, and associated with unfavorable consequences. There are limited studies examining…”
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Microbial efflux pump inhibition: tactics and strategies by Tegos, George P, Haynes, Mark, Strouse, J Jacob, Khan, Mohiuddin Md T, Bologa, Cristian G, Oprea, Tudor I, Sklar, Larry A

“…Traditional antimicrobials are increasingly suffering from the emergence of multidrug resistance among pathogenic microorganisms. To overcome these…”
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In vivo effects of a GPR30 antagonist by Dennis, Megan K, Burai, Ritwik, Ramesh, Chinnasamy, Petrie, Whitney K, Alcon, Sara N, Nayak, Tapan K, Bologa, Cristian G, Leitao, Andrei, Brailoiu, Eugen, Deliu, Elena, Dun, Nae J, Sklar, Larry A, Hathaway, Helen J, Arterburn, Jeffrey B, Oprea, Tudor I, Prossnitz, Eric R

“…Estrogen is central to many physiological processes throughout the human body. We have previously shown that the G protein–coupled receptor GPR30 (also known…”
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Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity by Dennis, Megan K., Field, Angela S., Burai, Ritwik, Ramesh, Chinnasamy, Petrie, Whitney K., Bologa, Cristian G., Oprea, Tudor I., Yamaguchi, Yuri, Hayashi, Shin-Ichi, Sklar, Larry A., Hathaway, Helen J., Arterburn, Jeffrey B., Prossnitz, Eric R.

“…► We identify a GPER antagonist G36 with increased selectivity against ERα/β. ► G36 exhibits reduced ER binding/activation compared to G15. ► G36 inhibits GPER…”
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A comprehensive map of molecular drug targets by Santos, Rita, Ursu, Oleg, Gaulton, Anna, Bento, A. Patrícia, Donadi, Ramesh S., Bologa, Cristian G., Karlsson, Anneli, Al-Lazikani, Bissan, Hersey, Anne, Oprea, Tudor I., Overington, John P.

“…Key Points The definition of a drug target is crucial to the success of mechanism-based drug discovery. It is also increasingly important for efforts to link…”
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TIGA: target illumination GWAS analytics by Yang, Jeremy J, Grissa, Dhouha, Lambert, Christophe G, Bologa, Cristian G, Mathias, Stephen L, Waller, Anna, Wild, David J, Jensen, Lars Juhl, Oprea, Tudor I

“…Abstract Motivation Genome-wide association studies can reveal important genotype–phenotype associations; however, data quality and interpretability issues…”
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Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist by Slack, Jay P., Brockhoff, Anne, Batram, Claudia, Menzel, Susann, Sonnabend, Caroline, Born, Stephan, Galindo, Maria Mercedes, Kohl, Susann, Thalmann, Sophie, Ostopovici-Halip, Liliana, Simons, Christopher T., Ungureanu, Ioana, Duineveld, Kees, Bologa, Cristian G., Behrens, Maik, Furrer, Stefan, Oprea, Tudor I., Meyerhof, Wolfgang

“…Human bitter taste is mediated by the hTAS2R family of G protein-coupled receptors [1–4]. The discovery of the hTAS2Rs enables the potential to develop…”
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High performance implementation of the hierarchical likelihood for generalized linear mixed models: an application to estimate the potassium reference range in massive electronic health records datasets by Bologa, Cristian G, Pankratz, Vernon Shane, Unruh, Mark L, Roumelioti, Maria Eleni, Shah, Vallabh, Shaffi, Saeed Kamran, Arzhan, Soraya, Cook, John, Argyropoulos, Christos

“…Converting electronic health record (EHR) entries to useful clinical inferences requires one to address the poor scalability of existing implementations of…”
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Badapple: promiscuity patterns from noisy evidence by Yang, Jeremy J., Ursu, Oleg, Lipinski, Christopher A., Sklar, Larry A., Oprea, Tudor I., Bologa, Cristian G.

“…Background Bioassay data analysis continues to be an essential, routine, yet challenging task in modern drug discovery and chemical biology research. The…”
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TIN-X: target importance and novelty explorer by Cannon, Daniel C, Yang, Jeremy J, Mathias, Stephen L, Ursu, Oleg, Mani, Subramani, Waller, Anna, Schürer, Stephan C, Jensen, Lars Juhl, Sklar, Larry A, Bologa, Cristian G, Oprea, Tudor I

“…The increasing amount of peer-reviewed manuscripts requires the development of specific mining tools to facilitate the visual exploration of evidence linking…”
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