Search Results - "Bolmont, Tristan"
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Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
Published in Neurobiology of aging (01-01-2017)“…Abstract The pathway leading from beta-amyloid deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer’s disease…”
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Transmission and spreading of tauopathy in transgenic mouse brain
Published in Nature cell biology (01-07-2009)“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Administrations of Human Adult Ischemia-Tolerant Mesenchymal Stem Cells and Factors Reduce Amyloid-Beta Pathology in a Mouse Model of Alzheimer’s Disease
Published in Neurobiology of aging (01-03-2017)“…Abstract The impact of human adult ischemia-tolerant mesenchymal stem cells (hMSC) and factors (SCF) on cerebral amyloid-beta (Aβ) pathology was investigated…”
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Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance
Published in The Journal of neuroscience (16-04-2008)“…Microglial cells aggregate around amyloid plaques in Alzheimer's disease, but, despite their therapeutic potential, various aspects of their reactive kinetics…”
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Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
Published in Proceedings of the National Academy of Sciences - PNAS (04-08-2009)“…Despite the importance of the aberrant polymerization of Aβ in the early pathogenic cascade of Alzheimer's disease, little is known about the induction of Aβ…”
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Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Published in EMBO reports (01-09-2006)“…We have generated a novel transgenic mouse model on a C57BL/6J genetic background that coexpresses KM670/671NL mutated amyloid precursor protein and L166P…”
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Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses
Published in ACS chemical biology (21-08-2009)“…Molecular probes for selective identification of protein aggregates are important to advance our understanding of the molecular pathogenesis underlying…”
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Stem cells for Alzheimer’s disease: transition to clinical trials
Published in Neurobiology of aging (01-03-2016)Get full text
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P2‐402: ADULT MESENCHYMAL STEM CELLS HAVE A POTENTIAL TO LOWER CEREBRAL ABETA AMYLOIDOSIS IN AN ALZHEIMER'S DISEASE MOUSE MODEL
Published in Alzheimer's & dementia (01-07-2014)Get full text
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ADULT MESENCHYMAL STEM CELLS HAVE A POTENTIAL TO LOWER CEREBRAL ABETA AMYLOIDOSIS IN AN ALZHEIMER'S DISEASE MOUSE MODEL
Published in Alzheimer's & dementia (01-07-2014)Get full text
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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Published in Science (American Association for the Advancement of Science) (22-09-2006)“…Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo…”
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Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
Published in Nature neuroscience (01-11-2009)“…In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or…”
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Quantitative cerebral blood flow imaging with extended-focus optical coherence microscopy
Published in Optics letters (01-01-2014)“…Quantitative three-dimensional blood flow imaging is a valuable technique to investigate the physiology of the brain. Two-photon microscopy (2PM) allows…”
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Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP x Tau Transgenic Mice
Published in The American journal of pathology (01-12-2007)“…Alzheimer's disease presents morphologically with senile plaques, primarily made of extracellular amyloid-beta (A beta) deposits, and neurofibrillary lesions,…”
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Quantitative lateral and axial flow imaging with optical coherence microscopy and tomography
Published in Optics express (29-07-2013)“…Optical coherence tomography (OCT) and optical coherence microscopy (OCM) allow the acquisition of quantitative three-dimensional axial flow by estimating the…”
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Exogenous Induction of Cerebral β-Amyloidogenesis Is Governed by Agent and Host
Published in Science (American Association for the Advancement of Science) (22-09-2006)“…Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo…”
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Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy
Published in The Journal of neuroscience (17-10-2012)“…We demonstrate label-free imaging of cerebral β-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended-focus Fourier domain…”
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STEM CELLS FOR ALZHEIMER'S DISEASE: SAFETY IN CLINICAL TRIALS
Published in Alzheimer's & dementia (01-07-2016)Get full text
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